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This paper investigates the behaviour of turbulence production in adverse pressure gradient (APG) turbulent boundary layers (TBLs), including the range of pressure gradients from zero-pressure-gradient (ZPG) to separation, moderate and high Reynolds numbers, and equilibrium and non-equilibrium flows. The main focus is on predicting the values and positions of turbulence production peaks. Based on the unique ability of turbulence production to describe energy exchange, the idea that the ratios of the mean flow length scales to the turbulence length scales are locally smallest near peaks is proposed. Thereby, the ratios of length scales are defined for the inner and outer regions, respectively, as well as the ratios of time scales for further consideration of local information. The ratios in the inner region are found to reach the same constant value in different APG TBLs. Like turbulence production in the ZPG TBL, turbulence production in APG TBLs is shown to have a certain invariance of the inner peak. The value and position of the inner peak can also be predicted quantitatively. In contrast, the ratios in the outer region cannot be determined with unique coefficients, which accounts for the different self-similarity properties of the inner and outer regions. The outer time scale ratios establish a link between mean flow and turbulence, thus participating in the discussion on half-power laws. The present results support the existence of a half-power-law region that is not immediately adjacent to the overlapping region.
Turbulent flow widely exists in the aerospace field, and it is still challenging to realise the accurate prediction in the numerical simulation. To realise the high-fidelity numerical simulation of compressible turbulent flow, a high-order accurate self-adaptive turbulence eddy simulation (SATES) method is developed on the PHengLEI-HyOrder open-source solver, combining with the high-order accurate weighted compact nonlinear schemes (WCNS). The compressible flow in the subsonic and transonic is numerically simulated, including some typical cases, such as subsonic flow past a circular cylinder and flow past a square cylinder, high-lift configuration DLR-F11, transonic flow around a circular cylinder. The results predicted by the current high-order accurate SATES are in good agreement with the available experimental and numerical data. The present numerical method can also accurately capture the interactions between shock waves and turbulence while accurately simulating flow separation, shear layer instability and large-scale vortex shedding. The results obtained show that the current high-order accurate SATES simulations based on PHengLEI-HyOrder solver can accurately simulate complex turbulent flows with high reliability.
This paper provides an overview of the current status of ultrafast and ultra-intense lasers with peak powers exceeding 100 TW and examines the research activities in high-energy-density physics within China. Currently, 10 high-intensity lasers with powers over 100 TW are operational, and about 10 additional lasers are being constructed at various institutes and universities. These facilities operate either independently or are combined with one another, thereby offering substantial support for both Chinese and international research and development efforts in high-energy-density physics.
Knowledge of the critical periods of crop–weed competition is crucial for designing weed management strategies in cropping systems. In the Lower Yangtze Valley, China, field experiments were conducted in 2011 and 2012 to study the effect of interference from mixed natural weed populations on cotton growth and yield and to determine the critical period for weed control (CPWC) in direct-seeded cotton. Two treatments were applied: allowing weeds to infest the crop or keeping plots weed-free for increasing periods (0, 1, 2, 4, 6, 8, 10, 12, 14, and 20 wk) after crop emergence. The results show that mixed natural weed infestations led to 35- to 55-cm shorter cotton plants with stem diameters 10 to 13 mm smaller throughout the season, fitting well with modified Gompertz and logistic models, respectively. Season-long competition with weeds reduced the number of fruit branches per plant by 65% to 82%, decreasing boll number per plant by 86% to 96% and single boll weight by approximately 24%. Weed-free seed cotton yields ranged from 2,900 to 3,130 kg ha−1, while yield loss increased with the duration of weed infestation, reaching up to 83% to 96% compared with permanent weed-free plots. Modified Gompertz and logistic models were used to analyze the impact of increasing weed control duration and weed interference on relative seed cotton yield (percentage of season-long weed-free cotton), respectively. Based on a 5% yield loss threshold, the CPWC was found to be from 145 to 994 growing degree days (GDD), corresponding to 14 to 85 d after emergence (DAE). These findings emphasize the importance of implementing effective weed control measures from 14 to 85 DAE in the Lower Yangtze Valley to prevent crop losses exceeding a 5% yield loss threshold.
The ubiquitous marine radiocarbon reservoir effect (MRE) constrains the construction of reliable chronologies for marine sediments and the further comparison of paleoclimate records. Different reference values were suggested from various archives. However, it remains unclear how climate and MREs interact. Here we studied two pre-bomb corals from the Hainan Island and Xisha Island in the northern South China Sea (SCS), to examine the relationship between MRE and regional climate change. We find that the MRE from east of Hainan Island is mainly modulated by the Southern Asian Summer Monsoon-induced precipitation (with 11.4% contributed to seawater), rather than wind induced upwelling. In contrast, in the relatively open seawater of Xisha Island, the MRE is dominated by the East Asian Winter Monsoon, with relatively more negative (lower) ΔR values associated with high wind speeds, implying horizontal transport of seawater. The average SCS ΔR value relative to the Marine20 curve is –161±39 14C years. Our finding highlights the essential role of monsoon in regulating the MRE in the northern SCS, in particularly the tight bond between east Asian winter monsoon and regional MRE.
The school–vacation cycle may have impacts on the psychological states of adolescents. However, little evidence illustrates how transition from school to vacation impacts students’ psychological states (e.g. depression and anxiety).
Aims
To explore the changing patterns of depression and anxiety symptoms among adolescent students within a school–vacation transition and to provide insights for prevention or intervention targets.
Method
Social demographic data and depression and anxiety symptoms were measured from 1380 adolescent students during the school year (age: 13.8 ± 0.88) and 1100 students during the summer vacation (age: 14.2 ± 0.93) in China. Multilevel mixed-effect models were used to examine the changes in depression and anxiety levels and the associated influencing factors. Network analysis was used to explore the symptom network structures of depression and anxiety during school and vacation.
Results
Depression and anxiety symptoms significantly decreased during the vacation compared to the school period. Being female, higher age and with lower mother's educational level were identified as longitudinal risk factors. Interaction effects were found between group (school versus vacation) and the father's educational level as well as grade. Network analyses demonstrated that the anxiety symptoms, including ‘Nervous’, ‘Control worry’ and ‘Relax’ were the most central symptoms at both times. Psychomotor disturbance, including ‘Restless’, ‘Nervous’ and ‘Motor’, bridged depression and anxiety symptoms. The central and bridge symptoms showed variation across the school vacation.
Conclusions
The school–vacation transition had an impact on students’ depression and anxiety symptoms. Prevention and intervention strategies for adolescents’ depression and anxiety during school and vacation periods should be differentially developed.
Measures of agreement are used in a wide range of behavioral, biomedical, psychosocial, and health-care related research to assess reliability of diagnostic test, psychometric properties of instrument, fidelity of psychosocial intervention, and accuracy of proxy outcome. The concordance correlation coefficient (CCC) is a popular measure of agreement for continuous outcomes. In modern-day applications, data are often clustered, making inference difficult to perform using existing methods. In addition, as longitudinal study designs become increasingly popular, missing data have become a serious issue, and the lack of methods to systematically address this problem has hampered the progress of research in the aforementioned fields. In this paper, we develop a novel approach to tackle the complexities involved in addressing missing data and other related issues for performing CCC analysis within a longitudinal data setting. The approach is illustrated with both real and simulated data.
To understand the dietary patterns of adults and explore their association with iodine nutritional levels and thyroid function in adults.
Design:
We randomly collected 5 ml of adult urine samples and measured urinary iodine concentration (UIC) by cerium arsenate-catalysed spectrophotometry. A serum sample of 5 ml was collected for the determination of free triiodothyronine, free thyroxine and thyrotropin, and diet-related information was collected through a FFQ. Dietary patterns were extracted by principal component analysis, and the relationship between dietary patterns and iodine nutrition levels and thyroid function was explored.
Settings:
A cross-sectional study involving adults in Xinjiang, China, was conducted.
Participants:
A total of 435 adults were enrolled in the study.
Results:
The overall median urinary iodine of the 435 respondents was 219·73 μg/l. The dietary patterns were PCA1 (staple food pattern), PCA2 (fruit, vegetable and meat pattern), PCA3 (fish, shrimp and legume pattern) and PCA4 (dairy-based protein pattern). The correlation analyses showed that PCA1 and PCA3 were positively correlated with the UIC. The results of the multivariable analysis showed that PCA1, Q1, Q2 and Q3 were associated with an increased risk of iodine deficiency compared with Q4 ((OR): 260·41 (95 % CI: 20·16, 663·70)), 59·89 (5·64, 335·81), and 2·01 (0·15, 26·16), respectively). In PCA2, Q3 was associated with an increased risk of iodine deficiency compared with Q4 (OR: 0·16 (0·05, 0·53)). In PCA3, Q3 was associated with an increased risk of iodine deficiency compared with Q4 (OR: 0·23 (0·06, 0·90)). In PCA4, Q1 was associated with an increased risk of iodine deficiency compared with Q4 (OR: 31·30 (4·88, 200·64)).
Conclusion:
This study demonstrated that of the four dietary patterns, the least dependent staple food pattern (Q1) had a higher risk of iodine deficiency compared with the most dependent staple food pattern (Q4). However, the current evidence on the effect of dietary patterns on thyroid function needs to be validated by further longitudinal studies that include long-term follow-up, larger sample sizes and repeated measures.
This paper systematically investigated the impact mechanisms of proton irradiation, atomic oxygen irradiation and space debris collision, both individually and in combination, on the laser damage threshold and damage evolution characteristics of HfO2/SiO2 triple-band high-reflection films and fused silica substrates using a simulated near-Earth space radiation experimental system. For the high-reflection film samples, the damage thresholds decreased by 15.38%, 13.12% and 46.80% after proton, atomic oxygen and simulated space debris (penetration) irradiation, respectively. The coupling irradiation of the first two factors resulted in a decrease of 26.93%, while the combined effect of all the three factors led to a reduction of 63.19%. Similarly, the fused silica substrates exhibited the same pattern of laser damage performance degradation. Notably, the study employed high-precision fixed-point in situ measurement techniques to track in detail the microstructural changes, surface roughness and optical-thermal absorption intensity before and after proton and atomic oxygen irradiation at the same location, thus providing a more accurate and comprehensive analysis of the damage mechanisms. In addition, simulations were conducted to quantitatively analyze the transmission trajectories and concentration distribution lines of protons and atomic oxygen incident at specific angles into the target material. The research findings contribute to elucidating the laser damage performance degradation mechanism of transmissive elements in near-Earth space environments and provide technical support for the development of high-damage-threshold optical components resistant to space radiation.
Genes involved in melanin production directly impact insect pigmentation and can affect diverse physiology and behaviours. The role these genes have on sex behaviour, however, is unclear. In the present study, the crucial melanin pigment gene black was functionally characterised in an urban pest, the German cockroach, Blattella germanica. RNAi knockdown of B. germanica black (Bgblack) had no effect on survival, but did result in black pigmentation of the thoraxes, abdomens, heads, wings, legs, antennae, and cerci due to cuticular accumulation of melanin. Sex-specific variation in the pigmentation pattern was apparent, with females exhibiting darker coloration on the abdomen and thorax than males. Bgblack knockdown also resulted in wing deformation and negatively impacted the contact sex pheromone-based courtship behaviour of males. This study provides evidence for black function in multiple aspects of B. germanica biology and opens new avenues of exploration for novel pest control strategies.
To meet the demands of laser-ion acceleration at a high repetition rate, we have developed a comprehensive diagnostic system for real-time and in situ monitoring of liquid sheet targets (LSTs). The spatially resolved rapid characterizations of an LST’s thickness, flatness, tilt angle and position are fulfilled by different subsystems with high accuracy. With the help of the diagnostic system, we reveal the dependence of thickness distribution on collision parameters and report the 238-nm liquid sheet generated by the collision of two liquid jets. Control methods for the flatness and tilt angle of LSTs have also been provided, which are essential for applications of laser-driven ion acceleration and others.
Under adverse pressure gradient (APG) conditions, the outer regions of turbulent boundary layers (TBLs) are characterized by an increased velocity defect $U_{e}-U$, an outwards shift of the peak value of the Reynolds shear stress $-\langle uv\rangle$ and an appearance of the outer peak value of the Reynolds normal stress $\langle uu\rangle$. Here $U_{e}$ is the TBL edge velocity. Scaling APG TBLs is challenging due to the non-equilibrium effects caused by changes in the APG. To address this, the response distance of TBLs to non-equilibrium conditions is utilized to extend the Zagarola–Smits scaling $U_{zs} = U_{e}({\delta ^{*} }/{\delta })$ and ensure that the original properties of the Zagarola–Smits scaling are maintained as $Re \to \infty$. Here $\delta ^{*}$ is the displacement thickness and $\delta$ is the boundary layer thickness. Based on the established correlation between $U_{e}-U$ and $-\langle uv\rangle$, the scaling is extended to $-\langle uv\rangle$. Furthermore, considering the coupling relationship between Reynolds stress components, the scaling is extended to encompass each Reynolds stress component. The proposed consistent scaling is verified using five non-equilibrium databases and five near-equilibrium databases, successfully collapsing the data of the TBL outer region. The pressure gradient parameter $\beta =({\delta ^{*} }/{\rho u_{\tau }^{2} }) ({\mathrm {d} P_{e} }/{\mathrm {d}\kern0.7pt x})$ of these databases spans two orders of magnitude. Here $P_{e}$ is the boundary layer edge pressure, $u_{\tau }$ is the friction velocity and $\rho$ is the density. Finally, the influence of the APG on the inner and outer regions of TBLs is analysed using the mean momentum balance equation. The analysis suggests that the shift of the $-\langle uv\rangle$ peak to the outer region under APG conditions is due to an insufficient inertia term near the inner region to balance the APG. It is observed that the APG promotes interaction between the inner and outer regions of TBLs, but the inner and outer regions still retain distinctive properties.
The Righi–Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh–Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic simulations. The perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of teslas. The Righi–Leduc effect plays an essential impact both in the linear and nonlinear stages, and it deflects the total heat flux towards the spike base. Compared to the case without the self-generated magnetic field included, less heat flux is concentrated at the spike tip, finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike tip. It is shown that the linear growth rate is increased by about 10% and the amplitude during the nonlinear stage is increased by even more than 10% due to the feedback of the magnetic field, respectively. Our results reveal the importance of Righi–Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field, especially during the acceleration stage in inertial confinement fusion.
Binary nanodroplet collisions have received increasing attention, whilst the identification of collision outcomes and the viscous dissipation mechanism have remained poorly understood. Using molecular dynamics simulations, this study investigates binary nanodroplet collisions over wide ranges of Weber number (We), Ohnesorge number (Oh) and off-centre distances. Coalescence, stretching separation and shattering are identified; however, bouncing, reflexive separation and rotational separation reported for millimetre-sized collisions are not observed, which is attributed to the enhanced viscous effect caused by the ‘natural’ high-viscosity characteristics of nanodroplets. Intriguingly, as an intermediate outcome, holes form in retracting films at relatively high We, arising from the vibration and thermal fluctuation of the films. Due to the combined effects of inertial, capillary and viscous forces, binary nanodroplet collisions fall into the cross-over regime, so estimating viscous dissipation becomes extremely important for distinguishing outcome boundaries. Based on the criterion that stretching separation is triggered only when the residual off-centre kinetic energy exceeds the surface energy required for separation, the boundary equation between coalescence and stretching separation is established. Here, viscous dissipation is calculated by the extracted flow feature from simulations, showing that the ratio of viscous dissipation to the initial kinetic energy depends only on Oh, not on We. Because of complex viscous dissipation mechanisms, the same boundary equation in the cross-over regime has also not been satisfactorily revealed for macroscale collisions. Therefore, the proposed equation is tested for wide data sources from both macroscale and nanoscale collisions, and satisfying agreement is achieved, demonstrating the universality of the equation.
Childhood maltreatment is an established risk factor for psychopathology. However, it remains unclear how childhood traumatic events relate to mental health problems and how the brain is involved. This study examined the serial mediation effect of brain morphological alterations and emotion-/reward-related functions on linking the relationship from maltreatment to depression. We recruited 156 healthy adolescents and young adults and an additional sample of 31 adolescents with major depressive disorder for assessment of childhood maltreatment, depressive symptoms, cognitive reappraisal and anticipatory/consummatory pleasure. Structural MRI data were acquired to identify maltreatment-related cortical and subcortical morphological differences. The mediation models suggested that emotional maltreatment of abuse and neglect, was respectively associated with increased gray matter volume in the ventral striatum and greater thickness in the middle cingulate cortex. These structural alterations were further related to reduced anticipatory pleasure and disrupted cognitive reappraisal, which contributed to more severe depressive symptoms among healthy individuals. The above mediating effects were not replicated in our clinical group partly due to the small sample size. Preventative interventions can target emotional and reward systems to foster resilience and reduce the likelihood of future psychiatric disorders among individuals with a history of maltreatment.
Here, we report the generation of MeV alpha-particles from H-11B fusion initiated by laser-accelerated boron ions. Boron ions with maximum energy of 6 MeV and fluence of 109/MeV/sr@5 MeV were generated from 60 nm-thick self-supporting boron nanofoils irradiated by 1 J femtosecond pulses at an intensity of 1019 W/cm2. By bombarding secondary hydrogenous targets with the boron ions, 3 × 105/sr alpha-particles from H-11B fusion were registered, which is consistent with the theoretical yield calculated from the measured boron energy spectra. Our results demonstrated an alternative way toward ultrashort MeV alpha-particle sources employing compact femtosecond lasers. The ion acceleration and product measurement scheme are referential for the studies on the ion stopping power and cross section of the H-11B reaction in solid or plasma.
The surface modification of Zeolite 4A using cetyl trimethyl ammonium bromide (CTAB) as a modifier via an ultrasonic method was carried out and the surface physicochemical properties measured. Response surface methodology (RSM) was developed with CTAB concentration, handling time, and handling temperature as variables, to help predict the performance of the modified zeolite under particular conditions. The influence of organic-modified surface treatment and of the amount of modified zeolite on the water-absorption capability of starch-g-poly (acrylic acid) hydrogel composites was also assessed. The results showed that the channels and skeleton structure of zeolite 4A were unchanged after organic modification by CTAB and the surface modification was effective. The results suggest that organic-modified zeolite 4A has improved the water-absorption capability.
Energy loss of protons with 90 and 100 keV energies penetrating through a hydrogen plasma target has been measured, where the electron density of the plasma is about 1016 cm−3 and the electron temperature is about 1-2 eV. It is found that the energy loss of protons in the plasma is obviously larger than that in cold gas and the experimental results based on the Bethe model calculations can be demonstrated by the variation of effective charge of protons in the hydrogen plasma. The effective charge remains 1 for 100 keV protons, while the value for 90 keV protons decreases to be about 0.92. Moreover, two empirical formulae are employed to extract the effective charge.
A peripherally inserted central catheter (PICC) is an important vascular access device to administer certain intravenous (IV) therapies, which is traditionally placed using fluoroscopy in radiology suites. With advancing tip-confirmation technology, PICCs can be placed at the patient bedside by nurses, without any delays arising from wait time for the radiology suite or the need of transferring patients to the radiology suite, leading to time savings and allowing prompt start to IV therapy. This study aims to estimate the cost and time impact of placing PICCs at the bedside using tip-confirmation technology led by nurses versus in the radiology suite using fluoroscopy by radiologists.
Methods
A budget impact analysis was developed using Microsoft Excel to estimate the annual impact of inserting PICCs at the bedside versus in the radiology suite. The base case scenario was modelled for 1,000 PICCs placed in a private Australian hospital. Impact on bed days, labor time and overall cost was estimated by using global and local data sources for inputs. It was assumed that 100 percent PICC are placed in a radiology suite in current practice, while 95 percent are placed at the bedside and 5 percent in the radiology suite in future practice.
Results
By shifting PICC insertion to the bedside using tip-confirmation technology, the model estimated a reduction of labor time by 221 hours and bed days by 113 days. Despite an increase in the cost of consumables by AUD34,041 (USD22,760) and reduction of Medicare Benefits Schedule rebate by AUD260,730 (USD174,328), overall cost savings of AUD1.01million (USD675,660) was observed due to significant savings due to the t reduced utilization of the radiology suite.
Conclusions
PICC insertion at the patient bedside using tip-confirmation technology by nurses may lead to time and cost savings as compared to placing them in the radiology suite. This can help alleviate the burden on radiology suites and reduce their wait times, potentially leading to timely treatment initiation and discharge. Since PICCs at the bedside are typically placed by specialized vascular access nurses, these cost savings can be redirected to employ and train them.
Up to 90 percent of inpatients require an intravenous catheter during their hospitalization. A closed, integrated peripheral intravenous catheter (PIVC) system has been shown to protect veins for longer and reduce the risk of complications and unnecessary restarts when compared with an open system. This study evaluated the annual clinical and economic outcomes of adopting a closed, integrated PIVC system, instead of an open system, for inpatients in a Japanese hospital.
Methods
A budget impact analysis was developed to estimate the clinical and economic impact for a 500-bed hospital with an 85 percent occupancy rate and a 96-hour catheter replacement protocol. For the analysis, the average length of stay for patients was 12 days and 90 percent of inpatients required a PIVC. Inputs such as catheter failure rate, complication rate, consumables costs, and complication management costs were informed by global and local data sources. The outcomes evaluated included consumables utilization, complication events, nurse time, and overall cost impact.
Results
The analysis estimated that 12,604 patients required PIVCs. Moving from an open to a closed, integrated PIVC system resulted in a 68 percent reduction in consumables (3,786 fewer catheters and 36,315 fewer connecting accessories). Complications (occlusion, extravasation, phlebitis, and bending) were reduced by 62 percent (3,682 fewer episodes). Blood exposure was reduced by 98 percent (3,565 fewer episodes), and nurse time decreased by 17 percent (786 fewer hours). This resulted in a potential overall cost saving of JPY3,955,140 (USD28,756) annually, after offsetting the acquisition cost of JPY888,247 (USD6,458) associated with the closed system.
Conclusions
PIVC is the most common vascular access device used in hospitals, and insertion and maintenance are often performed by nurses. Fewer complications can be expected with a closed system, leading to better patient outcomes. In addition, nurses spend less time managing complications and replacing PIVCs, and consumables utilization is reduced. This results in improved operational efficiency and potential cost savings for hospitals.