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This focused textbook demonstrates cutting-edge concepts at the intersection of machine learning (ML) and wireless communications, providing students with a deep and insightful understanding of this emerging field. It introduces students to a broad array of ML tools for effective wireless system design, and supports them in exploring ways in which future wireless networks can be designed to enable more effective deployment of federated and distributed learning techniques to enable AI systems. Requiring no previous knowledge of ML, this accessible introduction includes over 20 worked examples demonstrating the use of theoretical principles to address real-world challenges, and over 100 end-of-chapter exercises to cement student understanding, including hands-on computational exercises using Python. Accompanied by code supplements and solutions for instructors, this is the ideal textbook for a single-semester senior undergraduate or graduate course for students in electrical engineering, and an invaluable reference for academic researchers and professional engineers in wireless communications.
Offspring of parents with bipolar disorder (BD offspring) face elevated risks for emotional dysregulation and cognitive deficits, particularly in working memory. This study investigates working memory deficits and their neural correlates in BD offspring.
Methods
We assessed 41 BD offspring and 25 age-matched healthy controls (HCs) using a spatial N-back task and task-related functional magnetic resonance imaging (fMRI).
Results
Compared to HCs, BD offspring exhibit reduced accuracy and lower signal-detection sensitivity (d′) on the 1-back task. fMRI reveals hyperactivation in the right intracalcarine cortex/lingual gyrus (ICC/LG) in BD offspring, particularly during the 1-back condition. Psychophysiological interaction (PPI) analyses show reduced connectivity between the right ICC/LG and the left postcentral gyrus in BD offspring as task load increases from 0-back to 1-back. This connectivity positively correlates with 1-back task performance in HCs but not in BD offspring. Additionally, using bilateral dorsolateral prefrontal cortex (DLPFC) as regions of interest, PPI analyses show diminished condition-dependent connectivity between the left DLPFC and the left superior frontal gyrus/paracingulate cortex, and between the right DLPFC and the left postcentral gyrus/precentral gyrus in BD offspring as the task load increases.
Conclusions
These findings suggest that BD offspring exhibit working memory deficits and impaired neural connectivity involving both sensory processing and higher-order cognitive systems. Such deficits may emerge at a genetically predisposed stage of bipolar disorder, underscoring the significance of early identification and intervention strategies.
People, across a wide range of personal and professional domains, need to accurately detect whether the state of the world has changed. Previous research has documented a systematic pattern of over- and under-reaction to signals of change due to system neglect, the tendency to overweight the signals and underweight the system producing the signals. We investigate whether experience, and hence the potential to learn, improves people’s ability to detect change. Participants in our study made probabilistic judgments across 20 trials, each consisting of 10 periods, all in a single system that crossed three levels of diagnosticity (a measure of the informativeness of the signal) with four levels of transition probability (a measure of the stability of the environment). We found that the system-neglect pattern was only modestly attenuated by experience. Although average performance did not increase with experience overall, the degree of learning varied substantially across the 12 systems we investigated, with participants showing significant improvement in some high diagnosticity conditions and none in others. We examine this variation in learning through the lens of a simple linear adjustment heuristic, which we term the “δ-ϵ” model. We show that some systems produce consistent feedback in the sense that the best δ and ϵ responses for one trial also do well on other trials. We show that learning is related to the consistency of feedback, as well as a participant’s “scope for learning” how close their initial judgments are to optimal behavior.
The dispute of married out women has become an important modernisation problem since the 1990s as the result of urbanisation and industrialisation. It concerns social stability at grassroots that may affect the ruling base. While the Chinese government is constantly striving to solve it, it also shows how deficient the protection of women’s property rights is that it causes so many controversies. Currently, the cultural explanation that simply attributes the phenomenon to traditional patriarchal culture is popular among scholars and widely accepted, which is, however, proved to be misleading. This article attempts to break this stereotype and points out that this trouble is not directly related to Chinese traditional culture. Rather, it is caused by the majority’s tyranny under the current villager self-government and collective property rights. This article also attempts to find possible solutions, requiring improving the rural self-government system and clearly defining the boundaries of collective property rights by law.
This study evaluated the effects of chenodeoxycholic acid (CDCA), a farnesoid X receptor (FXR) potential activator, on growth performance, antioxidant capacity, glucose metabolism and inflammation in largemouth bass (Micropterus salmoides) (initial body weight: 5·45 ± 0·02 g) fed a high-carbohydrate diet. Experimental diets included a positive control (5 % α-starch), a negative control (10 % α-starch) and two diets containing 10 % α-starch supplemented with either 0·05 % or 0·10 % CDCA. After 8 weeks, the high-carbohydrate diet reduced growth performance and increased hepatosomatic and viscerosomatic indexes, which were mitigated by 0·10 % CDCA supplementation. The high-carbohydrate diet also increased hepatic glycogen and crude lipid content, both of which were reduced by 0·10 % CDCA. Furthermore, the high-carbohydrate diet-induced oxidative stress, histopathological changes and reduced liver lysozyme activity, which were ameliorated by CDCA supplementation. Molecular analysis showed that the high-carbohydrate diet suppressed FXR and phosphorylated AKT1 (p-AKT1) protein expression in the liver, downregulated insulin signalling (ira, irs, pi3kr1 and akt1), gluconeogenesis (pepck and g6pc) and glycolysis genes (gk, pk and pfkl). CDCA supplementation upregulated fxr expression, activated shp, enhanced the expression of insulin signalling and glycolytic genes (gk, pk and pfkl) and inhibited gluconeogenesis. Additionally, CDCA reduced inflammatory markers (nf-κb and il-1β) and restored anti-inflammatory mediators (il-10, iκb and tgf-β). In conclusion, 0·10 % CDCA improved carbohydrate metabolism and alleviated liver inflammation in largemouth bass fed a high dietary carbohydrate, partially through FXR activation.
In this paper, a cellular robot for space trusses is structured so that it can perform tasks such as moving the truss and assembling the truss. There may be some spatial operating mechanisms on the space truss that cause obstacles to the robot’s movement, especially other mobile mechanical devices that are working, which are dynamic obstacles, so a suitable path planning for the robot is needed. In path planning, A-star algorithm has the advantages of efficient searching speed and good optimization effect, but it can’t deal with the path planning problem with dynamic obstacles, so this paper improves Lifelong Planning A-star (LPA-star) algorithm so that the improved algorithm satisfies the dynamic path planning task. Then a three-dimensional truss mathematical model is established, a dynamic obstacle environment is set up, the improved LPA-star algorithm is used for path planning, and the unimproved LPA-star algorithm and the improved A-star algorithm are used to compare with it. The simulation results show that in the environment set up in this paper, the optimal path length of the improved LPA-star algorithm is shortened by about 25% and the algorithm search time is shortened by about 55% compared with the improved A-star algorithm; while the unimproved LPA-star algorithm is unable to accomplish the dynamic path planning task. Therefore, the improved LPA-star algorithm can reduce the robot’s moving distance and time consumption.
We have developed an interactive system comprising a soft wearable robot hand and a wireless task board, facilitating the interaction between the hand and regular daily objects for task-oriented training in stroke rehabilitation. A ring-reinforced soft actuator (RSA) to accommodate different hand sizes and enable flexion and extension movements was introduced in this paper. Individually controlled finger actuators assist stroke patients during various grasping tasks. A wireless task board was developed to support the training, allowing for the placement of training objects and seamless interaction with the soft robotic hand. Evaluation with seven stroke subjects shows significant improvements in upper limb functions (FMA), hand-motor abilities (ARAT, BBT), and maximum grip strengths after 20 sessions of this task-oriented training. These improvements were observed to persist for at least 3 months post-training. The results demonstrate its potential to enhance stroke rehabilitation and promote hand-motor recovery. This lightweight, user-friendly interactive system facilitates frequent hand practice and easily integrates into regular rehabilitation therapy routines.
Prehistoric humans seem to have preferred inhabiting small river basins, which were closer in distance to most settlements compared to larger rivers. The Holocene landscape evolution is considered to have played a pivotal role in shaping the spatiotemporal patterns of these settlements. In this study, we conducted comprehensive research on the relationship between landscape evolution and settlement distribution within the Huangshui River basin, which is a representative small river in Central China with numerous early settlements, including a prehistoric city known as the Wangjinglou site (WJL). Using geoarchaeological investigations, optically stimulated luminescence dating, pollen analysis, and grain-size analysis, we analyzed the characteristics of the Holocene environment. The results indicate the presence of two distinct geomorphic systems, namely the red clay hills and the river valley. The red clay hills, formed in the Neogene, represent remnants of the Songshan piedmont alluvial fan that was eroded by rivers. There are three grades of terraces within the river valley. T3 is a strath terrace and formed around 8.0 ka. Both T2 and T1 are fill terraces, which were developed around 4.0 ka and during the historical period, respectively. The sedimentary features and pollen analysis indicate the existence of an ancient lake-swamp on the platform during 11.0–9.0 ka. This waterbody gradually shrank during 9.0–8.0 ka, and ultimately disappeared after 8.0 ka. Since then, the development of large-scale areas of water ceased on the higher geomorphic units. River floods also cannot reach the top of these high geomorphic units, where numerous prehistoric settlements are located, including the Xia–Shang cities of the WJL site. Our research demonstrates that landscape stability supported the long-term and sustainable development of ancient cultures and facilitated the establishment of the WJL ancient cities in the region.
The double-cone ignition scheme is a promising novel ignition method, which is expected to greatly save the driver energy and enhance the robustness of the implosion process. In this paper, ablation of the inner surface of the cone by the hard X-ray from coronal Au plasma is studied via radiation hydrodynamics simulations. It is found that the X-ray ablation of the inner wall will form strong pre-plasma, which will significantly affect the implosion process and cause the Au plasma to mix with the fuel, leading to ignition failure. The radiation and pre-ablation intensities in the system are estimated, and the evolutions of areal density, ion temperature and the distribution of Au ions are analysed. In addition, the mixing of Au in CH at collision is quantified. Then, a scheme to reduce the X-ray pre-ablation by replacing the gold cone with a tungsten cone is proposed, showing that it is effective in reducing high-Z mixing and improving collision results.
Rapid advancements in high-energy ultrafast lasers and free electron lasers have made it possible to obtain extreme physical conditions in the laboratory, which lays the foundation for investigating the interaction between light and matter and probing ultrafast dynamic processes. High temporal resolution is a prerequisite for realizing the value of these large-scale facilities. Here, we propose a new method that has the potential to enable the various subsystems of large scientific facilities to work together well, and the measurement accuracy and synchronization precision of timing jitter are greatly improved by combining a balanced optical cross-correlator (BOC) with near-field interferometry technology. Initially, we compressed a 0.8 ps laser pulse to 95 fs, which not only improved the measurement accuracy by 3.6 times but also increased the BOC synchronization precision from 8.3 fs root-mean-square (RMS) to 1.12 fs RMS. Subsequently, we successfully compensated the phase drift between the laser pulses to 189 as RMS by using the BOC for pre-correction and near-field interferometry technology for fine compensation. This method realizes the measurement and correction of the timing jitter of ps-level lasers with as-level accuracy, and has the potential to promote ultrafast dynamics detection and pump–probe experiments.
In this study, nine isonitrogenous experimental diets containing graded levels of carbohydrates (40 g/kg, 80 g/kg and 120 g/kg) and crude lipids (80 g/kg, 120 g/kg and 160 g/kg) were formulated in a two-factor (3 × 3) orthogonal design. A total of 945 mandarin fish with similar body weights were randomly assigned to twenty-seven tanks, and the experiment diets were fed to triplicate tanks twice daily for 10 weeks. Results showed that different dietary treatments did not significantly affect the survival rate and growth performance of mandarin fish. However, high dietary lipid and carbohydrate levels significantly decreased the protein content of the whole body and muscle of cultured fish. The lipid content of the whole body, liver and muscle all significantly increased with increasing levels of dietary lipid, while only liver lipid level was significantly affected by dietary carbohydrate level. Hepatic glycogen content increased significantly with increasing dietary carbohydrate levels. As to liver antioxidant capacity, malondialdehyde content increased significantly with increasing dietary lipid or carbohydrate content, and catalase activity showed an opposite trend. Superoxide dismutase activity increased significantly with increasing levels of dietary lipid but decreased first and then increased with increasing dietary carbohydrate levels. Additionally, the increase in both dietary lipid and carbohydrate levels resulted in a significant reduction in muscle hardness. Muscle chewiness, gumminess and shear force were only affected by dietary lipid levels and decreased significantly with increasing dietary lipid levels. In conclusion, considering all the results, the appropriate dietary lipids and carbohydrate levels for mandarin fish were 120 g/kg and 80 g/kg, respectively.
Most research on intertemporal choice has examined choices between smaller, sooner gains and larger, later gains. A much smaller number of papers have examined intertemporal choices for losses. In this article, we explore whether mixed-sign choices with both gains and losses may better correlate with real-world behaviors. In two high-powered studies (pilot: N = 3,200; main study: N = 7,000), participants completed one of four normatively equivalent measures consisting of pure gain, pure loss, or mixed sign (Gain-Now-Loss-Later or Loss-Now-Gain-Later) intertemporal choices. Participants also self-reported a large number of demographic measures and real-world choice behaviors thought to be linked to intertemporal choice. The results indicate that (1) mixed-sign intertemporal choices yield more patient time preferences than pure-gain choices but less patient than pure-loss choices and (2) pure-gain intertemporal choices yield equivalent or superior predictive power across a range of real-world intertemporal choice behaviors.
We present the generation of high-repetition-rate strong-field terahertz (THz) pulses from a thin 4-N,N-dimethylamino-4’-N’-methyl-stilbazolium 2,4,6-trimethylbenzenesulfonate (DSTMS) organic crystal pumped by an ytterbium-doped yttrium aluminum garnet laser. The generated THz pulse energy reaches 932.8 nJ at 1 kHz repetition rate, with a conversion efficiency of 0.19% and a peak electric field of 819 kV/cm. At a repetition rate of 10 kHz, it is able to maintain a peak electric field of 236 kV/cm and an average THz power of 0.77 mW. The high-repetition-rate, strong-field THz source provides a convenient tool for the study of THz matter manipulation and THz spectroscopy.
Cancer diagnosis and treatment can result in a significant psychological burden. This study sought to investigate the prevalence of major depression, associated treatments, and suicidal ideation in cancer survivors compared to a non-cancer cohort.
Methods
This is a retrospective, population-based study using survey responses from the National Survey on Drug Use and Health collected from January 2015 to December 2019. Survey data sets were queried for all respondents who provided a cancer history. Respondents with a reported history of cancer (“cancer survivors”) were further stratified by whether they reported a “recent” cancer diagnosis within the past 12 months. Survey responses were evaluated for recent diagnoses of and treatments for major depressive disorder and suicidal ideation.
Results
Among the 212,411 survey respondents identified, 7,635 (3.6%) reported a cancer history, with 1,486 (0.7%) reporting a recent cancer history. There were no differences in prevalence of major depression between cancer survivors and participants without cancer (9.3% vs 9.2%, p = 0.762), though the prevalence was slightly higher among recent cancer survivors (10.0% vs 9.2%, p = 0.259). Among respondents diagnosed with major depression, cancer survivors were significantly more likely to receive treatment for depression (78.6% vs 60.3%, p < 0.001). Suicidal ideation was significantly lower among cancer survivors (5.1% vs 6.2%, p < 0.001) including recent survivors (5.0% vs 6.2%, p < 0.001).
Significance of results
There was no overall difference in the prevalence of major depression between cancer survivors and respondents without cancer. Survivors with major depression were more likely to receive treatments. Prevalence of major depression was higher in recent cancer survivors.
Supersonic internal flows often exhibit multiple reflected shocks within a limited distance. These shocks can interact with each other in a complex manner due to the characteristics of the shock wave–turbulent boundary layer interaction (STBLI), including flow distortion and the relaxing boundary layer. This study aims to characterise this type of interaction and to clarify its fluid physics. A separated STBLI zone was established either upstream or downstream, and another weaker STBLI was established in the opposing position to serve as a perturbation. Time-resolved measurements were employed to characterise the mean separation and unsteadiness as the two regions approached each other, as well as their relationship. The experimental results indicated that the STBLI could affect the separation and reattachment of the other STBLI through either the decelerated or relaxing boundary layer. Despite a small deflection angle, the incident shock can amplify the low-frequency oscillations in the downstream STBLI region. Additionally, the interaction in the downstream region can be influenced by both low- and high-frequency oscillations associated with the upstream STBLI through a relaxing boundary layer. Despite the limited correlation observed between the low-frequency fluctuations in the downstream region and the boundary layer flow not far upstream, there still exists some degree of correlation between the low-frequency shock motions even when they are widely separated. Both the ‘upstream mechanism’ and ‘downstream mechanism’ have been observed, and the significance of low-frequency dynamics in the separated flow, relative to that of the upstream flow, is closely associated with interaction intensity.
This study aimed to evaluate the association between vegetable intake and major depressive disorder (MDD) through cross-sectional analysis and bidirectional two-sample Mendelian randomisation (MR).
Design:
Cross-sectional analysis was conducted on National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018 and the corresponding Food Patterns Equivalents Database (FPED). Genome-wide association study (GWAS) data were obtained from UK Biobank and Psychiatric Genomics Consortium (PGC) dataset. Logistic regression analysis was performed after calculating the weights of the samples. Inverse variance weighted, MR-Egger and weighted median methods were used to evaluate the causal effects.
Setting:
A Patient Health Questionnaire-9 score ≥ 10 was considered to indicate MDD. Low vegetable intake was defined as < 2 cups of vegetables per day.
Participants:
30 861 U.S. adults from NHANES. The GWAS data sample size related to vegetable intake were comprised 448 651 and 435 435 cases respectively, while the GWAS data sample size associated with MDD encompassed 500 199 cases.
Results:
There were 23 249 (75·33 %) participants with low vegetable intake. The relationship between vegetable intake and MDD was nonlinear. In the multivariate model adjusted for sex, age, education, marital status, poverty income ratio, ethnicity and BMI, participants with low vegetable intake were associated with an increased risk of MDD (OR = 1·53, 95 % CI (1·32, 1·77), P < 0·001). Bidirectional MR showed no causal effects between vegetable intake and MDD.
Conclusions:
Cross-sectional analysis identified a significant relationship between vegetable intake and MDD, whereas the results from bidirectional two-sample MR did not support a causal role.
This study compared survival outcomes between intensive care unit (ICU) patients receiving enteral nutrition (EN) and parenteral nutrition (PN) with vasopressor support, explored risk factors affecting clinical outcomes and established an evaluation model. Data from 1046 ICU patients receiving vasopressor therapy within 24 h from 2008 to 2019 were collected. Patients receiving nutritional therapy within 3 d of ICU admission were divided into EN or PN (including PN+EN) groups. Cox analysis and regression were used to determine relevant factors and establish a nomogram for predicting survival. The 28-d survival rate was significantly better in the EN group compared with the PN/PN+EN group. Risk factors included age, peripheral capillary oxygen saturation, red cell distribution width, international normalised ratio, potassium level, mean corpuscular Hg, myocardial infarction, liver disease, cancer status and nutritional status. The nomogram showed good predictive performance. In ICU patients receiving vasopressor drugs, patients receiving EN had a better survival rate than PN. Our nomogram had favourable predictive value for 28-d survival in patients. However, it needs further validation in prospective trials.
Caused by multiple risk factors, heavy burden of major depressive disorder (MDD) poses serious challenges to public health worldwide over the past 30 years. Yet the burden and attributable risk factors of MDD were not systematically known. We aimed to reveal the long-term spatio-temporal trends in the burden and attributable risk factors of MDD at global, regional and national levels during 1990–2019.
Methods
We obtained MDD and attributable risk factors data from Global Burden of Disease Study 2019. We used joinpoint regression model to assess the temporal trend in MDD burden, and age–period–cohort model to measure the effects of age, period and birth cohort on MDD incidence rate. We utilized population attributable fractions (PAFs) to estimate the specific proportions of MDD burden attributed to given risk factors.
Results
During 1990–2019, the global number of MDD incident cases, prevalent cases and disability-adjusted life years (DALYs) increased by 59.10%, 59.57% and 58.57%, respectively. Whereas the global age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR) and age-standardized DALYs rate (ASDR) of MDD decreased during 1990–2019. The ASIR, ASPR and ASDR in women were 1.62, 1.62 and 1.60 times as that in men in 2019, respectively. The highest age-specific incidence, prevalence and DALYs rate occurred at the age of 60–64 in women, and at the age of 75–84 in men, but the maximum increasing trends in these age-specific rates occurred at the age of 5–9. Population living during 2000–2004 had higher risk of MDD. MDD burden varied by socio-demographic index (SDI), regions and nations. In 2019, low-SDI region, Central sub-Saharan Africa and Uganda had the highest ASIR, ASPR and ASDR. The global PAFs of intimate partner violence (IPV), childhood sexual abuse (CSA) and bullying victimization (BV) were 8.43%, 5.46% and 4.86% in 2019, respectively.
Conclusions
Over the past 30 years, the global ASIR, ASPR and ASDR of MDD had decreased trends, while the burden of MDD was still serious, and multiple disparities in MDD burden remarkably existed. Women, elderly and populations living during 2000–2004 and in low-SDI regions, had more severe burden of MDD. Children were more susceptible to MDD. Up to 18.75% of global MDD burden would be eliminated through early preventing against IPV, CSA and BV. Tailored strategies-and-measures in different regions and demographic groups based on findings in this studywould be urgently needed to eliminate the impacts of modifiable risk factors on MDD, and then mitigate the burden of MDD.
Double-cone ignition [Zhang et al., Phil. Trans. R. Soc. A 378, 20200015 (2020)] was proposed recently as a novel path for direct-drive inertial confinement fusion using high-power lasers. In this scheme, plasma jets with both high density and high velocity are required for collisions. Here we report preliminary experimental results obtained at the Shenguang-II upgrade laser facility, employing a CHCl shell in a gold cone irradiated with a two-ramp laser pulse. The CHCl shell was pre-compressed by the first laser ramp to a density of 3.75 g/cm3 along the isentropic path. Subsequently, the target was further compressed and accelerated by the second laser ramp in the cone. According to the simulations, the plasma jet reached a density of up to 15 g/cm3, while measurements indicated a velocity of 126.8 ± 17.1 km/s. The good agreements between experimental data and simulations are documented.