Direct numerical simulations are performed to explore the evolution behaviour of the turbulent/non-turbulent interface (TNTI) in a temporally evolving turbulent plane jet, using the evolution equation for the TNTI surface area. A novel algorithm is used to calculate the surface area of the TNTI and entrainment flux. It is shown that the surface area remains relatively constant, which leads to the mean entrainment velocity being inversely proportional to the square root of time. On average, the effects of the stretching and curvature/viscous terms on the TNTI area roughly counterbalance each other, while the curvature/inviscid term associated with vortex stretching is virtually zero. More specifically, the stretching term contributes to the production of the surface area, while the curvature/viscous term is associated with a destruction in the surface area. The local effect of the curvature/viscous term exhibits high spatial intermittency with small-scale extreme/intense events, whereas the effect of the large-scale stretching term is more continuous. To shed light on the contribution of curvature/viscous term to the evolution of the surface area, we decompose it into three components. The effect of the curvature/normal diffusion term (the curvature/viscous dissipation term) in the bulging regions (the valley regions) mainly contributes to the production of the area. The continuous decrease of the average mean curvature is associated with the production of the bulging regions and the destruction of the valley regions. Finally, although the entrainment velocity is mainly dominated by the normal diffusion effect, all three components related to the viscous effect are indispensable to the production and destruction of the TNTI area. This numerical study contributes to a better understanding of the evolution of the TNTI area.

In this paper, a capsule endoscopy system with a sensing function is proposed for medical devices. A single-arm spiral antenna is designed for data transmission and is combined with the voltage controlled oscillator to achieve sensing capabilities. The designed antenna operates at a 900 MHz industrial scientific medical band. By establishing a three-layer cylindrical model of the stomach, it was concluded that the antenna in the stomach has a high peak gain of −1.1 dBi. Additionally, the antenna achieved a −10 dB impedance bandwidth of 5%. The capsule endoscopy was experimentally measured in both actual stomach and simulated environments. The maximum working distance of the capsule endoscope was measured to be 6.8 m. Additionally, the proposed capsule endoscope was tested for its sensing function using solutions with different dielectric constants. Finally, it was confirmed through link analysis that it has good communication capabilities. The results and analysis confirm that the proposed capsule endoscope can be used for examining gastric diseases.

Structural damage in turbomachinery is a primary origin of aeronautic accidents, which is receiving increased attention. This study is thus focused on the aeroelastic analysis of damaged blades, including the onset of flutter and underlying mechanisms. First, a high-fidelity fluid–solid coupling system is established with computational fluid dynamics (CFD) and computational structural dynamics (CSD) technologies, via which the dynamic aeroelastic analysis is conducted based on static aeroelastic deformation. Second, a damaged rotor blade is parametrically modelled with variable damage levels, extents, and positions. Finally, the modal identification method of spectral proper orthogonal decomposition (SPOD) is applied to observe flow details and provide physical insight into the flutter mechanism for damaged blades. Numerical analysis finds that there is a critical damage level below which the aeroelastic stability is positively improved with increasing damage level; otherwise, a significant loss of stability is induced. The damage location and extent further affect this critical damage level and the change rate crossing the threshold. The simulation with CFD/CSD finds that the high pressure near the trailing edge induced from boundary layer separation suppresses vibrations in stable conditions, but motivates vibrations during flutter, which is because of the high-pressure spread to nearing blades. SPOD modes reveal that high-frequency disturbances with large scale are primary factors inducing flutter, which is further stimulated by the high-order disturbances with small scale. This study provides a crucial foundation for the fatigue prediction for rotor blades in service and the optimisation design for high-performance turbomachinery in the near future.

We report on an experimental study of turbulent Rayleigh–Bénard convection with asymmetric top and bottom plates. The plates are covered with pyramid-shaped roughness elements whose aspect ratios are $\lambda =1$ or $\lambda =4$. In the low-Rayleigh-number regime ($Ra<1.9\times 10^9$), the heat transport efficiencies in the asymmetric cells, characterized by the Nusselt number, are smaller than those measured in a symmetric $\lambda = 1$ cell and are greater than those for a symmetric $\lambda = 4$ cell, whereas in the high-Rayleigh-number regime ($Ra>1.9\times 10^9$), the Nusselt numbers of the asymmetric cells are, in turn, greater than those for the symmetric cell with $\lambda = 1$ and smaller than those for the symmetric cell with $\lambda = 4$. In addition, the heat transports of individual plates are studied based on the temperature drops across both halves of the cell. In the low-$Ra$ regime, the $\lambda =1$ plate shows higher heat transfer than the $\lambda =4$ plate, while for the high-$Ra$ regime, the $\lambda =4$ plate shows a higher heat transport ability. In both regimes, the individual Nusselt number of the plate with lower heat transfer is insensitive to the topology of the other plate. Besides, it is found that the symmetry of the centre temperature distribution is robust to the symmetry breaking of boundary topographies. For the $Ra$ range explored, a weak temperature inversion is observed in the bulk of asymmetric rough cells. Finally, we remark that the temperature fluctuation at the cell centre and the Reynolds number associated with the large-scale circulation show universal power laws in terms of the flux Rayleigh number as $\sigma _{T_{c}}\sim Ra_F^{0.68}$ and $Re_{LSC}\sim Ra_F^{0.36}$, respectively.

We report a numerical investigation of a previously noticed but less explored flow state transition in two-dimensional turbulent Rayleigh–Bénard convection. The simulations are performed in a square domain over a Rayleigh number range of $10^7 \leq Ra \leq 2 \times 10^{11}$ and a Prandtl number range of $0.25 \leq Pr \leq 20$. The transition is characterized by the emergence of multiple satellite eddies with increasing $Ra$, which orbit around and interact with the main vortex roll in the system. Consequently, the main roll is squeezed to a smaller size compared with the domain and wanders around in the bulk region irregularly and extensively. This is in sharp contrast to the flow state before the transition, which is featured by a domain-sized circulatory roll with its vortex centre ‘condensed’ near the domain's centre. Detailed velocity field analysis reveals that there exists an abrupt increase in the energy fluctuations of the Fourier modes during the transition. Based on this phase-transition-like signal, the critical condition for the transition is found to follow a scaling relation as $Ra_t \sim Pr^{1.41}$ where $Ra_t$ is the critical Rayleigh number for the transition. This scaling relation is quantitatively explained by a phenomenological model grounded on the bistability behaviour (i.e. spontaneous and stochastic switching between the two flow states) observed at the edge of the transition. The model can also account for the effects of aspect ratio on the transition reported in the literature (van der Poel et al., Phys. Fluids, vol. 24, 2012).

MicroRNAs (miRNAs) play important roles in regulating salt tolerance in Dongxiang wild rice (DXWR, Oryza rufipogon Griff.). The development of salt-responsive miRNA-simple sequence repeat (SSR) markers will significantly bolster research on DXWR, providing novel tools for exploring salt-tolerant genetic resources and advancing the development of salt-tolerant rice varieties. In the present study, a total of 137 miRNA-SSR markers were successfully developed, specifically derived from miRNAs responsive to salt stress in DXWR. Subsequently, a subset of 20 markers was randomly selected for validation across three distinct DXWR populations, along with 35 modern rice varieties. Notably, 13 of these markers exhibited remarkable polymorphism. The polymorphic markers collectively amplified 52 SSR loci, averaging four alleles per locus. The polymorphism information content values associated with these loci spanned from 0.23 to 0.70, with a mean value of 0.49. Particularly noteworthy is the miR162a-SSR marker, which demonstrated distinct allelic patterns and holds potential as a diagnostic marker for discriminating the salt-tolerant rice varieties from the non-tolerant varieties. This study provides a valuable tool for genetic analysis and precision breeding, facilitating the identification and utilization of valuable salt-tolerant genetic resources.

MicroRNAs (miRNAs) are endogenous, non-coding RNAs, which are functional in a variety of biological processes through post-transcriptional regulation of gene expression. However, the role of miRNAs in the interaction between Bacillus thuringiensis and insects remains unclear. In this study, small RNA libraries were constructed for B. thuringiensis-infected (Bt) and uninfected (CK) Spodoptera exigua larvae (treated with double-distilled water) using Illumina sequencing. Utilising the miRDeep2 and Randfold, a total of 233 known and 726 novel miRNAs were identified, among which 16 up-regulated and 34 down-regulated differentially expressed (DE) miRNAs were identified compared to the CK. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that potential target genes of DE miRNAs were associated with ABC transporters, fatty acid metabolism and MAPK signalling pathway which are related to the development, reproduction and immunity. Moreover, two miRNA core genes, SeDicer1 and SeAgo1 were identified. The phylogenetic tree showed that lepidopteran Dicer1 clustered into one branch, with SeDicer1 in the position closest to Spodoptera litura Dicer1. A similar phylogenetic relationship was observed in the Ago1 protein. Expression of SeDicer1 increased at 72 h post infection (hpi) with B. thuringiensis; however, expression of SeDicer1 and SeAgo1 decreased at 96 hpi. The RNAi results showed that the knockdown of SeDicer1 directly caused the down-regulation of miRNAs and promoted the mortality of S. exigua infected by B. thuringiensis GS57. In conclusion, our study is crucial to understand the relationship between miRNAs and various biological processes caused by B. thuringiensis infection, and develop an integrated pest management strategy for S. exigua via miRNAs.

We present a systematic study on the effects of small aspect ratios $\varGamma$ on heat transport in liquid metal convection with a Prandtl number of $Pr=0.029$. The study covers $1/20\le \varGamma \le 1$ experimentally and $1/50\le \varGamma \le 1$ numerically, and a Rayleigh number $Ra$ range of $4\times 10^3 \le Ra \le 7\times 10^{9}$. It is found experimentally that the local effective heat transport scaling exponent $\gamma$ changes with both $Ra$ and $\varGamma$, attaining a $\varGamma$-dependent maximum value before transition-to-turbulence and approaches $\gamma =0.25$ in the turbulence state as $Ra$ increases. Just above the onset of convection, Shishkina (Phys. Rev. Fluids, vol 6, 2021, 090502) derived a length scale $\ell =H/(1+1.49\varGamma ^{-2})^{1/3}$. Our numerical study shows $Ra_{\ell }$, i.e. $Ra$ based on $\ell$, serves as a proper control parameter for heat transport above the onset with $Nu-1=0.018(1+0.34/\varGamma ^2)(Ra/Ra_{c,\varGamma }-1)$. Here $Ra_{c,\varGamma }$ represents the $\varGamma$-dependent critical $Ra$ for the onset of convection and $Nu$ is the Nusselt number. In the turbulent state, for a general scaling law of $Nu-1\sim Ra^\alpha$, we propose a length scale $\ell = H/(1+1.49\varGamma ^{-2})^{1/[3(1-\alpha )]}$. In the case of turbulent liquid metal convection with $\alpha =1/4$, our measurement shows that the heat transport will become weakly dependent on $\varGamma$ with $Ra_{\ell }\equiv Ra/(1+1.49\varGamma ^{-2})^{4/3} \ge 7\times 10^5$. Finally, once the flow becomes time-dependent, the growth rate of $Nu$ with $Ra$ declines compared with the linear growth rate in the convection state. A hysteresis is observed in a $\varGamma =1/3$ cell when the flow becomes time-dependent. Measurements of the large-scale circulation suggest the hysteresis is caused by the system switching from a single-roll-mode to a double-roll-mode in an oscillation state.

Using thermal convection in liquid metal, we show that strong spatial confinement not only delays the onset Rayleigh number $Ra_c$ of Rayleigh–Bénard instability but also postpones the various flow-state transitions. The $Ra_c$ and the transition to fully developed turbulence Rayleigh number $Ra_f$ depend on the aspect ratio $\varGamma$ with $Ra_c\sim \varGamma ^{-4.05}$ and $Ra_f\sim \varGamma ^{-3.01}$, implying that the stabilization effects caused by the strong spatial confinement are weaker on the transition to fully developed turbulence when compared with that on the onset. When the flow state is characterized by the supercritical Rayleigh number $Ra/Ra_{c}$ ($Ra$ is the Rayleigh number), our study shows that the transition to fully developed turbulence in strongly confined geometries is advanced. For example, while the flow becomes fully developed turbulence at $Ra\approx 200Ra_c$ in a $\varGamma =1$ cell, the same transition in a $\varGamma =1/20$ cell only requires $Ra\approx 3Ra_c$. Direct numerical simulation and linear stability analysis show that in the strongly confined regime, multiple vertically stacked roll structures appear just above the onset of convection. With an increase of the driving strength, the flow switches between different-roll states stochastically, resulting in no well-defined large-scale coherent flow. Owing to this new mechanism that only exists in systems with $\varGamma <1$, the flow becomes turbulent in a much earlier stage. These findings shed new light on how turbulence is generated in strongly confined geometries.

We demonstrate the generation, spectral broadening and post-compression of second harmonic pulses using a thin beta barium borate (BBO) crystal on a fused-silica substrate as the nonlinear interaction medium. By combining second harmonic generation in the BBO crystal with self-phase modulation in the fused-silica substrate, we efficiently generate millijoule-level broadband violet pulses from a single optical component. The second harmonic spectrum covers a range from long wave ultraviolet (down to 310 nm) to visible (up to 550 nm) with a bandwidth of 65 nm. Subsequently, we compress the second harmonic beam to a duration of 4.8 fs with a pulse energy of 0.64 mJ (5 fs with a pulse energy of 1.05 mJ) using chirped mirrors. The all-solid free-space apparatus is compact, robust and pulse energy scalable, making it highly advantageous for generating intense second harmonic pulses from near-infrared femtosecond lasers in the sub-5 fs regime.

Very metal-poor (VMP, [Fe/H]<-2.0) stars serve as invaluable repositories of insights into the nature and evolution of the first-generation stars formed in the early galaxy. The upcoming China Space Station Telescope (CSST) will provide us with a large amount of spectral data that may contain plenty of VMP stars, and thus it is crucial to determine the stellar atmospheric parameters ($T_{\textrm{eff}}$, $\log$ g, and [Fe/H]) for low-resolution spectra similar to the CSST spectra ($R\sim 200$). This study introduces a novel two-dimensional Convolutional Neural Network (CNN) model, comprised of three convolutional layers and two fully connected layers. The model’s proficiency is assessed in estimating stellar parameters, particularly metallicity, from low-resolution spectra ($R \sim 200$), with a specific focus on enhancing the search for VMP stars within the CSST spectral data. We mainly use 10 008 spectra of VMP stars from LAMOST DR3, and 16 638 spectra of non-VMP stars ([Fe/H]>-2.0) from LAMOST DR8 for the experiments and apply random forest and support vector machine methods to make comparisons. The resolution of all spectra is reduced to $R\sim200$ to match the resolution of the CSST, followed by pre-processing and transformation into two-dimensional spectra for input into the CNN model. The validation and practicality of this model are also tested on the MARCS synthetic spectra. The results show that using the CNN model constructed in this paper, we obtain Mean Absolute Error (MAE) values of 99.40 K for $T_{\textrm{eff}}$, 0.22 dex for $\log$ g, 0.14 dex for [Fe/H], and 0.26 dex for [C/Fe] on the test set. Besides, the CNN model can efficiently identify VMP stars with a precision rate of 94.77%, a recall rate of 93.73%, and an accuracy of 95.70%. This paper powerfully demonstrates the effectiveness of the proposed CNN model in estimating stellar parameters for low-resolution spectra ($R\sim200$) and recognizing VMP stars that are of interest for stellar population and galactic evolution work.

A typical feature of thermal convection is the formation of large-scale flow (LSF) structures of the order of system size. How this structure affects global heat transport is an important issue in the study of thermal convection. We present an experimental study of the coupling between the flow structure and heat transport in liquid metal convection with different degrees of spatial confinement, characterized by the aspect ratio $\varGamma$ of the convection cell. Combining measurements in two convection cells with $\varGamma =1.0$ and 0.5, the study shows that a large-scale circulation (LSC) transports ${\sim }35\,\%$ more heat than a twisted LSC. It is further found that when the LSF is in the form of the LSC state, the system is in a fully developed turbulence state with a $Nu\sim Ra^{0.29}$ scaling for the heat transport. However, the twisted LSC state with a heat transport scaling of $Nu\sim Ra^{0.37}$ appears when the system is not in the fully developed turbulence state. Bistability is observed when the system evolves from the twisted-LSC-dominated to the LSC-dominated state.

We conducted a retrospective, analytical cross-sectional and single-centre study that included 190 hospitalised COVID-19 patients in the Fujian Provincial Hospital South Branch between December 2022 and January 2023 to analyse the correlation of viral loads of throat swabs with clinical progression and outcomes. To normalise the Ct value as quantification of viral loads, we used RNase P gene as internal control gene and subtracted the Ct value of SARS-CoV-2 N gene from the Ct value of RNase P gene, termed △Ct. Most patients were discharged (84.2%), and only 10 (5.6%) individuals who had a lower △Ct value died. The initial △Ct value of participants was also significantly correlated with some abnormal laboratory characteristics, and the duration time of SARS-CoV-2 was longer in patients with severe symptoms and a lower △Ct value at admission. Our study suggested that the △Ct value may be used as a predictor of disease progression and outcomes in hospitalised COVID-19 patients.

Pie charts are often used to communicate risk, such as the risk of driving. In the foreground-background salience effect (FBSE), foreground (probability of bad event) has greater salience than background (no bad event) in such a chart. Experiment 1 confirmed that the displays format of pie charts showed a typical FBSE. Experiment 2 showed that the FBSE resulted from a difference in cognitive efforts in processing the messages and that a foreground-emphasizing display was easier to process. Experiment 3 manipulated subjects’ information processing mindset and explored the interaction between displays format and information processing mindset. In the default mindset, careless subjects displayed a typical FBSE, while those who were instructed to be careful reported similar risk-avoidant behavior preference reading both charts. Suggestions for improving risk communication are discussed.

We present an experimental study of Rayleigh–Bénard convection using liquid metal alloy gallium-indium-tin as the working fluid with a Prandtl number of $Pr=0.029$. The flow state and the heat transport were measured in a Rayleigh number range of $1.2\times 10^{4} \le Ra \le 1.3\times 10^{7}$. The temperature fluctuation at the cell centre is used as a proxy for the flow state. It is found that, as $Ra$ increases from the lower end of the parameter range, the flow evolves from a convection state to an oscillation state, a chaotic state and finally a turbulent state for $Ra>10^5$. The study suggests that the large-scale circulation in the turbulent state is a residual of the cell structure near the onset of convection, which is in contrast with the case of $Pr\sim 1$, where the cell structure is transiently replaced by high order flow modes before the emergence of the large-scale circulation in the turbulent state. The evolution of the flow state is also reflected by the heat transport characterised by the Nusselt number $Nu$ and the probability density function (p.d.f.) of the temperature fluctuation at the cell centre. It is found that the effective local heat transport scaling exponent $\gamma$, i.e. $Nu\sim Ra^{\gamma }$, changes continuously from $\gamma =0.49$ at $Ra\sim 10^4$ to $\gamma =0.25$ for $Ra>10^6$. Meanwhile, the p.d.f. at the cell centre gradually evolves from a Gaussian-like shape before the transition to turbulence to an exponential-like shape in the turbulent state. For $Ra>10^6$, the flow shows self-similar behaviour, which is revealed by the universal shape of the p.d.f. of the temperature fluctuation at the cell centre and a $Nu=0.19Ra^{0.25}$ scaling for the heat transport.

Let $p$ be a prime number. Kęstutis Česnavičius proved that for an abelian variety $A$ over a global field $K$, the $p$-Selmer group $\mathrm {Sel}_{p}(A/L)$ grows unboundedly when $L$ ranges over the $(\mathbb {Z}/p\mathbb {Z})$-extensions of $K$. Moreover, he raised a further problem: is $\dim _{\mathbb {F}_{p}} \text{III} (A/L) [p]$ also unbounded under the above conditions? In this paper, we give a positive answer to this problem in the case $p \neq \mathrm {char}\,K$. As an application, this result enables us to generalize the work of Clark, Sharif and Creutz on the growth of potential $\text{III}$ in cyclic extensions. We also answer a problem proposed by Lim and Murty concerning the growth of the fine Tate–Shafarevich groups.

In this study, we report the first complete mitochondrial genome of the tapeworm Nippotaenia mogurndae in the order Nippotaeniidea Yamaguti, 1939. This mitogenome, which is 14,307 base pairs (bp) long with an A + T content of 72.2%, consists of 12 protein-coding genes, 22 transfer RNA (tRNA) genes, two rRNA genes, and two non-coding regions. Most tRNAs have a conventional cloverleaf structure, but trnS1 and trnR lack dihydrouridine arms of tRNA. The two largest non-coding regions, NCR1 (220 bp) and NCR2 (817 bp), are located between trnY and trnS2 and between nad5 and trnG, respectively. Phylogenetic analyses of mitogenomic data indicate that N. mogurndae is closely related to tapeworms in the order Cyclophyllidea.

The effect of centrifugal force in turbulent rotating Rayleigh–Bénard convection (RRBC) is studied experimentally in an aspect-ratio $\varGamma =1$ cylindrical convection cell and in the ranges of the Froude number $0.004\leq Fr \leq 0.363$ and the Rayleigh number $2.8\times 10^8 \leq Ra \leq 9.5\times 10^9$, and with the Prandtl number fixed at $Pr=4.34$. We use the bulk temperature anomaly to determine the onset Froude number $Fr_c$, beyond which the centrifugal effects cannot be regarded as insignificant. It is found that $Fr_c$ depends on $Ra$ as $Fr_c\sim Ra^{0.53}$, which may be understood qualitatively by the idea of local force balance. For $Fr>Fr_c$, the centrifugal effect is more pronounced for smaller $Ra$, which is also found for larger constant $1/Ro$. This implies that the response of the system to the centrifugal force depends on the flow states, which, in RRBC, is mainly determined by the competition between the buoyancy and Coriolis forces. Detailed analysis of the sidewall temperature signal shows results consistent with those obtained from the bulk temperature. Based on the above results, we propose a different division of the $1/Ro$–$Fr$ phase space than previously suggested. For the heat transport, the results under fixed $1/Ro$ show well-defined $Nu$–$Ra$ scalings, which can provide a better prediction for the heat transport when extrapolating to the unexplored regions in the phase space.