Double-zero-event studies (DZS) pose a challenge for accurately estimating the overall treatment effect in meta-analysis (MA). Current approaches, such as continuity correction or omission of DZS, are commonly employed, yet these ad hoc methods can yield biased conclusions. Although the standard bivariate generalized linear mixed model (BGLMM) can accommodate DZS, it fails to address the potential systemic differences between DZS and other studies. In this article, we propose a zero-inflated bivariate generalized linear mixed model (ZIBGLMM) to tackle this issue. This two-component finite mixture model includes zero inflation for a subpopulation with negligible or extremely low risk. We develop both frequentist and Bayesian versions of ZIBGLMM and examine its performance in estimating risk ratios against the BGLMM and conventional two-stage MA that excludes DZS. Through extensive simulation studies and real-world MA case studies, we demonstrate that ZIBGLMM outperforms the BGLMM and conventional two-stage MA that excludes DZS in estimating the true effect size with substantially less bias and comparable coverage probability.

Contrafreeloading (CFL) refers to animals’ tendency to prefer obtaining food through effort rather than accessing food that is freely available. Researchers have proposed various hypotheses to explain this intriguing phenomenon, but few studies have provided a comprehensive analysis of the factors influencing this behaviour. In this study, we observed the choice of alternative food containers in budgerigars (Melopsittacus undulatus) to investigate their CFL tendencies and the effects of pre-training, food deprivation, and effort required on the CFL tasks. The results showed that budgerigars did not exhibit significant difference in their first choices or the time interacting with less challenging versus more challenging food containers. Moreover, when evaluating each budgerigar’s CFL level, only half of them were identified as strong contrafreeloaders. Thus, we suggest that budgerigars exhibit an intermediate CFL level that lies somewhere between a strong tendency and the absence of such behaviour. Furthermore, we also found that food-deprived budgerigars tended to select less challenging food containers, and pre-trained budgerigars were more likely to choose highly challenging food containers than moderately challenging food containers, which means that the requirement of only a reasonable effort (access to food from moderately challenging food containers in this study) and the experience of pre-training act to enhance their CFL levels, whereas the requirement of greater effort and the experience of food deprivation act to decrease their CFL levels. Studying animal CFL can help understand why animals choose to expend effort to obtain food rather than accessing it for free, and it also has implications for setting feeding environments to enhance the animal welfare of captive and domesticated animals.

Let $K={\mathbb {Q}}(\sqrt {-7})$ and $\mathcal {O}$ the ring of integers in $K$. The prime $2$ splits in $K$, say $2{\mathcal {O}}={\mathfrak {p}}\cdot {\mathfrak {p}}^*$. Let $A$ be an elliptic curve defined over $K$ with complex multiplication by $\mathcal {O}$. Assume that $A$ has good ordinary reduction at both $\mathfrak {p}$ and ${\mathfrak {p}}^*$. Write $K_\infty$ for the field generated by the $2^\infty$–division points of $A$ over $K$ and let ${\mathcal {G}}={\mathrm {Gal}}(K_\infty /K)$. In this paper, by adopting a congruence formula of Yager and De Shalit, we construct the two-variable $2$-adic $L$-function on $\mathcal {G}$. Then by generalizing De Shalit’s local structure theorem to the two-variable setting, we prove a two-variable elliptic analogue of Iwasawa’s theorem on cyclotomic fields. As an application, we prove that every branch of the two-variable measure has Iwasawa $\mu$ invariant zero.

Rhopalosiphum padi is an important grain pest, causing severe losses during crop production. As a systemic insecticide, flonicamid can control piercing-sucking pests efficiently. In our study, the lethal effects of flonicamid on the biological traits of R. padi were investigated via a life table approach. Flonicamid is highly efficiently toxic to R. padi, with an LC50 of 9.068 mg L−1. The adult longevity and fecundity of the R. padi F0 generation were markedly reduced under the LC25 and LC50 concentrations of flonicamid exposure. In addition, negative transgenerational effects on R. padi were observed under exposure to lethal concentrations of flonicamid, with noticeable decreases in the reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation under the LC25 concentration of flonicamid. Furthermore, the third nymph stage (N3), preadult stage, duration of the adult pre-reproductive period, duration of the total pre-reproductive period, reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation were significantly lower under treatment with the LC50 concentration of flonicamid. The life table parameters were subsequently analysed, revealing that the intrinsic rate of increase (rm) and the net reproductive rate (R0) were significantly lower but that the finite rate of increase (λ) and the mean generation time (T) were not significantly different under the LC25 and LC50 concentrations of flonicamid. These data are beneficial for grain aphid control and are critical for exploring the role of flonicamid in the integrated management of this key pest.

A compact microstrip eight-channel diplexer based on quad-mode stepped impedance resonator (QMSIR) is proposed in this paper. The proposed diplexer is composed by two second-order quad-band bandpass filters (BPFs) and common-port distributed coupling matching circuit. Each quad-band BPF is formed by two coupled-QMSIRs controlling the passband characteristics. By introducing multiple coupling paths between input and output ports, the isolation between the eight channels is performed. For demonstration, an eight-channel diplexer based on QMSIR is designed and fabricated with microstrip technology. The use of the QMSIR can lead to significant size reduction for the multiplexer, this is because the required resonator number is reduced. As a result, the diplexer occupies a compact size of 0.083λ2, which is smaller than most of the eight-channel diplexers that have been proposed. And the 3 dB fractional bandwidth is 97% (2.5–7.2 GHz). Measurement results correlate well with the simulated predictions, showing that a good isolation of better than 20 dB and upper stopband of better than 10 dB.

Multiple osteoarticular tuberculosis (MOT) represents an uncommon yet severe form of tuberculosis, characterized by a lack of systematic analysis and comprehension. Our objective was to delineate MOT’s epidemiological characteristics and establish a scientific foundation for prevention and treatment. We conducted searches across eight databases to identify relevant articles. Pearson’s chi-square test (Fisher’s exact test) and Bonferroni method were employed to assess osteoarticular involvement among patients of varying age and gender (α = 0.05). The study comprised 98 articles, encompassing 151 cases from 22 countries, with China and India collectively contributing 67.55% of cases. MOT predominantly affected individuals aged 0–30 years (58.94%). Pulmonary tuberculosis was evident in 16.55% of cases, with spinal involvement prevalent (57.62%). Significant differences were noted in trunk, spine, thoracic, and lumbar vertebrae involvement, as well as type I lesions across age groups, increasing with age. Moreover, significant differences were observed in upper limb bone involvement and type II lesions across age groups, decreasing with age. Gender differences were not significant. MOT primarily manifests in China and India, predominantly among younger individuals, indicating age-related variations in osteoarticular involvement. Enhanced clinical awareness is crucial for accurate MOT diagnosis, mitigating missed diagnoses and misdiagnoses.

External seeded free-electron lasers (FELs) have exhibited substantial progress in diverse applications over the last decade. However, the frequency up-conversion efficiency in single-stage seeded FELs, particularly in high-gain harmonic generation (HGHG), remains constrained to a modest level. This limitation restricts its capability to conduct experiments within the ‘water window’. This paper presents a novel method for generating coherent X-ray FEL pulses in the water window region based on the HGHG scheme with multi-stage harmonic cascade. Without any additional modifications to the HGHG configuration, simulation results demonstrate the generation of intense 3 nm coherent FEL radiation using an external ultraviolet seed laser. This indicates an increase of the harmonic conversion number to approximately 90. A preliminary experiment is performed to evaluate the feasibility of this method. The proposed approach could potentially serve as an efficient method to broaden the wavelength coverage accessible to both existing and planned seeded X-ray FEL facilities.

Although dietary factors have been examined as potential risk factors for liver cancer, the evidence is still inconclusive. Using a diet-wide association analysis, our research evaluated the associations of 126 foods and nutrients on the risk of liver cancer in a Chinese population. We obtained the diet consumption of 72,680 women in the Shanghai Women’s Health Study using baseline dietary questionnaires. The association between each food and nutrient and liver cancer risk was quantified by Cox regression model. A false discovery rate of 0.05 was used to determine the foods and nutrients which need to be verified. Totally 256 incident liver cancer cases were identified in 1,267,391 person-years during the follow-up duration. At the statistical significance level (P ≤ 0.05), higher intakes of cooked wheaten foods, pear, grape and copper were inversely associated with liver cancer risk, while spinach, leafy vegetables, eggplant and carrots showed the positive associations. After considering multiple comparisons, no dietary variable was associated with liver cancer risk. Similar findings were seen in the stratification, secondary and sensitivity analyses. Our findings observed no significant association between dietary factors and liver cancer risk after considering multiple comparisons in Chinese women. More evidence is needed to explore the associations between diet and female liver cancer occurrence.

A high-energy pulsed vacuum ultraviolet (VUV) solid-state laser at 177 nm with high peak power by the sixth harmonic of a neodymium-doped yttrium aluminum garnet (Nd:YAG) amplifier in a KBe2BO3F2 prism-coupled device was demonstrated. The ultraviolet (UV) pump laser is a 352 ps pulsed, spatial top-hat super-Gaussian beam at 355 nm. A high energy of a 7.12 mJ VUV laser at 177 nm is obtained with a pulse width of 255 ps, indicating a peak power of 28 MW, and the conversion efficiency is 9.42% from 355 to 177 nm. The measured results fitted well with the theoretical prediction. It is the highest pulse energy and highest peak power ever reported in the VUV range for any solid-state lasers. The high-energy, high-peak-power, and high-spatial-uniformity VUV laser is of great interest for ultra-fine machining and particle-size measurements using UV in-line Fraunhofer holography diagnostics.

In this paper, we investigate Kolmogorov-type theorems for small perturbations of degenerate Hamiltonian systems. These systems are index by a parameter ξ as $ H(y,x,\xi) = \langle\omega(\xi),y\rangle {+ \bar h(y,\xi)}+\varepsilon P(y,x,\xi,\varepsilon) $, where ɛ > 0. We assume that the frequency mapping $\omega(\cdot)$, $\bar h(y,\cdot)=O(|y|^2)$ and the perturbation $\varepsilon P(y,x,\cdot, \varepsilon)$ maintain Hölder continuity about ξ. We prove that the persistent invariant tori retain the same frequency as those of the unperturbed tori, under a certain topological degree condition and a weak convexity condition for the frequency mapping. Notably, this paper presents, to our understanding, pioneering results on the KAM theorem under such conditions with only assumption of Hölder continuous dependence of frequency mapping ω on the parameter.

In recent years, dangerous gas leakage events occur frequently. Rapid and accurate location of gas leakage sources by mobile robots is the key to avoid the expansion of disasters. In order to solve the problem of discontinuous gas concentration gradient and sparse gas environment in three-dimensional space, particle filter, and whale swarm optimization algorithm are integrated to locate gas source. Firstly, the Z-shape search and comb search are used to locate the plume, and then, the particle filter algorithm is combined with the whale optimization method to guide the particle movement, and the random inertial disturbance term is designed to improve the convergence speed and search accuracy of the algorithm. Experimental results in three-dimensional environment show that the proposed information-driven particle filter whale optimization hybrid algorithm effectively guides the robot in localizing gas source within a certain range, significantly enhancing both the efficiency and accuracy of localization compared to other algorithms.

Over the last decade, we have gained a better understanding of impulse control disorder in Parkinson’s disease (PD-ICD), a medication complication in PD. Researchers were aware of its complexity and took efforts to learn more about its diagnostic and treatment possibilities. Nevertheless, clinical management for it is currently neglected. We conducted a narrative overview of literature published from 2012 to October 2023 on various aspects of clinical management for PD-ICD. A potential “susceptibility-catalytic-stress” model in the development of PD-ICD was proposed and a profile encoding predictors for PD-ICD was created. Based on these predictors, some methods for prediction were recently developed for better prediction, such as the polymorphic dopamine genetic risk score and the clinic-genetic ICD-risk score. A variety of treatment options, including dose reduction of dopamine receptor agonists (DAs), DAs removal, DAs switch, and add-on therapy, are investigated with inconsistent reports. Based on current findings, we developed a clinical management model prototype centered on prevention, consisting of prediction, prevention, follow-up and monitoring, therapy, and recurrence prevention, for clinical reference, and further proposed 4 key clinical management principles, including standardization, prediction centered, persistence, and whole course.