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Direct numerical simulations are performed to elucidate the influence of counter- and co-rotation on turbulent viscoelastic Taylor–Couette flow in the Rossby number range $ \textit{Ro}^{-1}=-0.6$ to $ \textit{Ro}^{-1}=1$. A novel polymer-induced transition pathway is discovered that is fundamentally different from Newtonian flows. In the counter-rotation regime, the neutral surface is elastically modified and separates the turbulent inner-wall region containing chaotic vortices from the relaminarised layer adjacent to the outer cylinder. Strikingly, co-rotation triggers an elasto-rotational instability, which leads to the breakdown of large-scale Taylor vortices into small-scale penetrating structures, thereby preventing the relaminarisation at high co-rotation rates. Examination of turbulence dynamics demonstrates that the structural changes with increasing $ \textit{Ro}^{-1}$ are accompanied by a transition from elasto-inertial to elastically dominated turbulence. Specifically, the polymer stress progressively exceeds the Reynolds stress and monotonically enhances angular momentum transport, which eliminates the optimal transport characteristic found in the Newtonian flow. The elastically dominated nature of the turbulent flow under co-rotation is further corroborated by the more significant elastic production of the turbulent kinetic energy, as well as the monotonic enhancement of the polymer elongation as $ \textit{Ro}^{-1}$ increases. Furthermore, it is indicated that the polymer orientation strongly depends on vortical structures, with enhanced radial alignment occurring in the boundary region between adjacent vortices. This vortex-mediated polymer orientation is crucial for generating substantial polymer shear stress, establishing a direct link between coherent structures and polymer dynamics.
In the present study, we propose a novel skin-friction prediction formula based on a re-established self-similarity within the adverse-pressure-gradient (APG) turbulent boundary layer. The basic idea lies in introducing a novel velocity scale, which is derived mathematically and adapted physically from the linear total stress within the boundary layer. This scale assimilates concurrently and fundamentally the friction velocity, two distinct pressure-gradient velocity scales and the half-power law of the mean velocity in the intermediate region. Then, this scale formula is well validated across a comprehensive, multi-geometry database of APG flows over flat plates, curved plates, ramps and airfoils, which covers an unprecedented parameter range, with friction Reynolds number ranging from $10^2$ to $5\times 10^3$ and the Rotta–Clauser pressure-gradient parameter spanning from $10^{-1}$ to $10^2$. Crucially, the proposed scale consistently recovers a classical logarithmic region across all tested APG conditions, thereby restoring the self-similar structures traditionally absent in strong or non-equilibrium pressure-gradient flows. Leveraging this reconstructed self-similarity, we further formulate a new, robust skin-friction prediction model which demonstrates predictive errors confined within $\pm 20\,\%$ for all the investigated non-equilibrium flow states.
Understanding how prehistoric human groups sustained themselves upon encountering novel island environments is crucial for modelling population movements in key world regions like Southeast Asia. Here, the authors present new radiocarbon dates and isotopic data for human and animal remains recovered from the Neolithic site of Xiying on Haitan Island, on the south-east China coast. The human remains are the earliest yet discovered on the island, their stable isotope ratios revealing a lifelong heavy reliance on marine foods despite the availability of a diversity of terrestrial resources, offering new insights into human adaptive flexibility in maritime environments.
The hydrodynamic interactions involved in the self-organisation phenomenon in biological systems are not fully understood and have attracted significant attention. A previous study (Peng et al. 2018 J. Fluid Mech., vol. 853, pp. 587–600) found that, arranged in an unbounded fluid, the largest cluster of self-propelled bodies in tandem, capable of spontaneously forming an ordered configuration, consists of eight swimmers. Here, we numerically investigate the collective behaviour of multiple self-propelled plates in tandem within a channel of width $H$, confined by two parallel walls. These plates are driven by harmonic flapping motions of uniform frequency and amplitude. Results demonstrate for the first time that the channel confinement significantly enhances group cohesion, with up to 72 individuals self-organising into ordered configurations at an optimal channel width. We observe two stable configurations: a hybrid mode with subgroups (typically at smaller channel widths) and a regular mode with sparse configuration. In large regular-mode groups, the vortex fields downstream exhibit spatial periodicity, conforming to Rosenhead’s stability criterion for confined vortex streets (vortex spacing $L_{v\textit{or}} \geqslant 1.419H$). This theoretical alignment explains both the observed upper channel-width limit ($H \approx 4.0{-}4.5$) for large-scale cohesion and the robust order in the regular mode. The plates may adopt spontaneously a ‘vortex-slalom’ path, reducing the drag force and energy consumption while maximising stability. Deviation from this path results in a spring-like restoring force, promptly returning the plate to equilibrium.
Depression as a mental illness is commonly observed to co-occur with various somatic diseases, such as gastrointestinal diseases. However, previous studies have primarily focused on the risk of mental disorders following physical illnesses. Our study took depression as a risk factor, attempting to explore its relationship with gastrointestinal diseases.
Methods
A total of 457,940 participants (aged 37–73 years) in the UK Biobank were included. The Cox proportional hazards model was used to assess the relationship between depression and gastrointestinal diseases. Mendelian randomization assessed the causal link between depression and gastrointestinal disorders, and seven machine learning algorithms (including LightGBM, XGBoost, and Random Forest) were trained in the total population to develop predictive models for incident gastrointestinal diseases, with model performance evaluated using the area under the receiver operating characteristic curve (AUC).
Results
During a median follow-up period of 13.7 years, 9563 esophagitis events, 36,420 gastroesophageal reflux disease events, 5469 gastric ulcer events, 3096 duodenal ulcer events, 37,225 gastritis and duodenitis events, and 9153 dyspepsia events were recorded. After adjusting for covariates, depression was associated with increased risk of all six diseases. Two-sample MR analysis supported a causal association. Machine learning models demonstrated good discrimination, with the highest predictive accuracy observed for duodenal ulcer (AUC = 0.76) and gastric ulcer (AUC = 0.75).
Conclusions
Addressing depression as a modifiable risk factor may reduce gastrointestinal disease risk, especially in disadvantaged populations, by integrating mental health care into primary care and using predictive models for early intervention.
Compressible wall-bounded turbulent flows exhibit complex mean profiles because of the pronounced compressibility effects and heat transfer. We propose a hybrid transformation framework to collapse compressible mean velocity and temperature profiles onto incompressible forms through scaling each layer by its effective transformation, with the underlying mapping functions discovered via a physics-informed symbolic regression (PISR) method. The hybrid velocity transformation incorporates an intrinsic compressibility correction for the buffer layer and a PISR-derived mapping function for the logarithmic layer. For temperature, we introduce a hybrid transformation that integrates the Mach-invariant-type transformation in the viscous sublayer and a novel PISR-derived scaling in the logarithmic layer. The performance of these transformations is evaluated across compressible turbulent boundary layers with free-stream Mach numbers ranging from 0.5 to 8 and wall-to-recovery-temperature ratios ranging from 0.25 to 1. The hybrid velocity transformation outperforms Griffin–Fu–Moin transformation for the transformed mean velocity profiles, with the mean integrated percent error across the dataset decreasing from 1.67 % to 0.96 %. The hybrid temperature transformation performs better than the Mach-invariant-type and Trettel–Larsson-type transformations for mean temperature profiles. Moreover, the inverse hybrid velocity and temperature transformations can effectively predict the compressible mean velocity and temperature profiles with only wall conditions.
Khasi nightshade (Solanum khasianum C.B. Clarke) is a perennial poisonous weed in tropical and subtropical regions that seriously threatens the development of grasslands. For a high-risk invasive weed, a comprehensive understanding of its seed germination characteristics is important for predicting its spread and developing effective management strategies. However, the impact of various abiotic factors on the germination of S. khasianum is not clear. This study first explored the effects of temperature, light, pH, osmotic stress, salt stress, high-temperature pretreatment, and burial depth on the germination of S. khasianum. Seeds germinated at constant temperature of 30, 33, 35, and 38 C, and the germination rate (GR) ranged from 10% to 94%. The optimum germination temperature was 35 C, while germination was completely inhibited at 25 or 40 C. The germination of S. khasianum was greatly promoted by alternating light and darkness (16/8, 12/12, 8/16 h), but was not sensitive to the time change of photoperiod. The GRs were more than 70% in the pH range of 4 to 10, and a strongly acidic environment was more suitable for germination. The GR gradually decreased with the osmotic potential from 0 to −0.2 MPa, and no germination occurred at −0.4 MPa. Accordingly, germination was also low in sodium chloride (NaCl) solution with concentrations higher than 60 mM. Seeds of S. khasianum were not tolerant to high temperature; GR decreased significantly after exposure to 40 C for 5 min, and it decreased to 3% at 120 C. The emergence rate was the highest (93%) when the seeds were buried on the soil surface, while seedlings hardly appeared when the burial depth was more than 2 cm. This study revealed the possible adaptive mechanism of invasive S. khasianum and will contribute to the effective prediction of its spread and management in grasslands.
Although deep reinforcement learning (DRL) techniques have been extensively studied in the field of robotic manipulators, there is limited research on directly mapping the output of policy functions to the joint space of manipulators. This paper proposes a motion planning scheme for redundant manipulators to avoid obstacles based on DRL, considering the actual shapes of obstacles in the environment. This scheme not only accomplishes the path planning task for the end-effector but also enables autonomous obstacle avoidance while obtaining the joint trajectories of the manipulator. First, a reinforcement learning framework based on the joint space is proposed. This framework uses the joint accelerations of the manipulator to calculate the Cartesian coordinates of the end-effector through forward kinematics, thereby performing end-to-end path planning for the end-effector. Second, the distance between all the linkages of the manipulator and irregular obstacles is calculated in real time based on the Gilbert–Johnson–Keerthi distance algorithm. The reward function containing joint acceleration is constructed with this distance to realize the obstacle avoidance task of the redundant manipulator. Finally, simulations and physical experiments were conducted on a 7-degree-of-freedom manipulator, demonstrating that the proposed scheme can generate efficient and collision-free trajectories in environments with irregular obstacles, effectively avoiding collisions.
Wall pressure fluctuations (WPFs) over aerodynamic surfaces contribute to the physical origin of noise generation and vibrational loading. Understanding the generation mechanism of WPFs, especially those exhibiting extremely high amplitudes, is important for advancing design and control in practical applications. In this work, we systematically investigate extreme events of WPFs in turbulent boundary layers and the compressibility effects thereon. The compressibility effects, encompassing extrinsic and intrinsic ones, ranging from weak to strong, are achieved by varying Mach numbers and wall temperatures. A series of datasets at moderate Reynolds numbers obtained from direct numerical simulation are analysed. It is found that the intermittency of WPFs depends weakly on extrinsic compressibility effects, whereas intrinsic compressibility effects significantly enhance intermittency at small scales. Coherent structures related to extreme events are identified using volumetric conditional average. Under extrinsic compressibility effects, extreme events are associated with the weak dilatation structures induced by interactions of high- and low-speed motions. When intrinsic compressibility effects dominate, these events are associated with the strong alternating positive and negative dilatation structures embedded in low-speed streaks. Furthermore, Poisson-equation-based pressure decomposition is performed to partition pressure fluctuations into components governed by distinct physical mechanisms. By analysing the proportion of each pressure component in extreme events, it is found that the contributions of the slow pressure and viscous pressure exhibit weak dependence on the compressibility effects, especially the extrinsic ones, and the varying trend of contributions of the rapid pressure with compressibility effects is opposite to that of the compressible pressure component.
Excavations at Aketala reveal traces of human activity at the oases of the western Tarim Basin, north-western China, by at least 2200 BC. The recovered artefacts indicate that, by 1800 BC, the Andronovo culture had reached this region, bringing agropastoralism and developing the earliest regional evidence of bronze manufacturing techniques.
We aimed to investigate the association between plasma advanced glycation end products (AGE) level and fat, skeletal muscle-related body composition parameters in middle-aged and elderly Chinese participants. A total of 1139 participants aged over 40 years were included in a cross-sectional study. Body composition including BMI, waist:hip ratio (WHR), fat mass index (FMI), percentage of body fat (PBF), the ratio of trunk fat to legs fat (trunk fat/legs fat), fat free mass (FFM), fat free mass index (FFMI) and skeletal muscle index (SMI) was measured using a bioelectrical impedance analyser. Plasma free and combined AGE were measured by ultra-high performance liquid chromatography-tandem MS. Multiple linear regression and weighted quantile sum regression models were used to examine the association between AGE and body composition parameters. Total exposure of plasma advanced glycation end products (AGE) was positively associated with BMI (β (95 % CI): 0·381 (0·037, 0·724), P = 0·030), FMI (β (95 % CI): 0·521 (0·241, 0·800), P = 0·001), PBF (β (95 % CI): 1·996 (1·160, 2·832), P < 0·0001), trunk fat/legs fat (β (95 % CI): 0·058 (0·036, 0·080), P < 0·001); while it was negatively associated with FFM (β (95 % CI): −1·075 (–2·028, –0·122), P = 0·027), FFMI (β (95 % CI): −0·687 (–1·076, –0·297), P = 0·001) and SMI (β (95 % CI): −1·264 (–1·767, –0·761), P < 0·001). The associations between plasma AGE and FFM and FFMI were more pronounced in those aged less than 61 years and female participants. This study provides evidence on the associations between plasma AGE and fat and skeletal muscle parameters, suggesting their potential role in the development of obesity and skeletal muscle loss.
The extracellular matrices, such as the haemolymph, in insects are at the centre of most physiological processes and are protected from oxidative stress by the extracellular antioxidant enzymes. In this study, we identified two secreted superoxide dismutase genes (PxSOD3 and PxSOD5) and investigated the oxidative stress induced by chlorpyrifos (CPF) in the aquatic insect Protohermes xanthodes (Megaloptera: Corydalidae). PxSOD3 and PxSOD5 contain the signal peptides at the N-terminus. Structure analysis revealed that PxSOD3 and PxSOD5 contain the conserved CuZn-SOD domain, which is mainly composed of β-sheets and has conserved copper and zinc binding sites. Both PxSOD3 and PxSOD5 are predicted to be soluble proteins located in the extracellular space. After exposure to different concentrations of sublethal CPF, MDA content in P. xanthodes larvae were increased in a dose-dependent manner; SOD and CAT activities were also higher in CPF-treated groups than that in the no CPF control, indicating that sublethal CPF induces oxidative stress in P. xanthodes larvae. Furthermore, PxSOD3 and PxSOD5 expression levels and haemolymph SOD activity in the larvae were downregulated by sublethal CPF at different concentrations. Our results suggest that the PxSOD3 and PxSOD5 are putative extracellular antioxidant enzymes that may play a role in maintaining the oxidative balance in the extracellular space. Sublethal CPF may induce oxidative stress in the extracellular space of P. xanthodes by reducing the gene expression and catalytic activity of extracellular SODs.
Cavitation bubble pulsation and liquid jet loads are the main causes of hydraulic machinery erosion. Methods to weaken the load influences have always been hot topics of related research. In this work, a method of attaching a viscous layer to a rigid wall is investigated in order to reduce cavitation pulsations and liquid jet loads, using both numerical simulations and experiments. A multiphase flow model incorporating viscous effects has been developed using the Eulerian finite element method (EFEM), and experimental methods of a laser-induced bubble near the viscous layer attached on a rigid wall have been carefully designed. The effects of the initial bubble–wall distance, the thickness of the viscous layer, and the viscosity on bubble pulsation, migration and wall pressure load are investigated. The results show that the bubble migration distance, the normalised thickness of the oil layer and the wall load generally decrease with the initial bubble–wall distance or the oil-layer parameters. Quantitative analysis reveals that when the initial bubble–wall distance remains unchanged, there exists a demarcation line for the comparison of the bubble period and the reference period (the bubble period without viscous layer under the same initial bubble–wall distance), and a logarithmic relationship is observed that $\delta \propto \log_{10} \mu ^*$, where $\delta =h/R_{max}$ is the thickness of the viscous layer h normalised by the maximum bubble radius $R_{max}$, $\mu ^* = \mu /({R_{max }}\sqrt {{\rho }{{\mathop {P}\nolimits } _{{atm}}}})$ is the dynamic viscosity $\mu$ normalised by water density $ \rho $ and atmospheric pressure $P_{atm}$. The results of this paper can provide technical support for related studies of hydraulic cavitation erosion.
Hand, foot, and mouth disease (HFMD) shows spatiotemporal heterogeneity in China. A spatiotemporal filtering model was constructed and applied to HFMD data to explore the underlying spatiotemporal structure of the disease and determine the impact of different spatiotemporal weight matrices on the results. HFMD cases and covariate data in East China were collected between 2009 and 2015. The different spatiotemporal weight matrices formed by Rook, K-nearest neighbour (KNN; K = 1), distance, and second-order spatial weight matrices (SO-SWM) with first-order temporal weight matrices in contemporaneous and lagged forms were decomposed, and spatiotemporal filtering model was constructed by selecting eigenvectors according to MC and the AIC. We used MI, standard deviation of the regression coefficients, and five indices (AIC, BIC, DIC, R2, and MSE) to compare the spatiotemporal filtering model with a Bayesian spatiotemporal model. The eigenvectors effectively removed spatial correlation in the model residuals (Moran’s I < 0.2, p > 0.05). The Bayesian spatiotemporal model’s Rook weight matrix outperformed others. The spatiotemporal filtering model with SO-SWM was superior, as shown by lower AIC (92,029.60), BIC (92,681.20), and MSE (418,022.7) values, and higher R2 (0.56) value. All spatiotemporal contemporaneous structures outperformed the lagged structures. Additionally, eigenvector maps from the Rook and SO-SWM closely resembled incidence patterns of HFMD.
Language control in the bilingual brain has remained in the limelight of research over the past decades. However, the mechanisms underlying bilingual language control may be more intricate than typically assumed due to the hierarchical nature of language. This study aimed to investigate the dynamics of bilingual language control at the phonetic level. Participants, who were speakers of Chinese, English and German, named the letters of the alphabet in English (L2) or German (L3) following an alternating language-switching paradigm. Two sets of letters were selected, differing in the phonological similarity of their pronunciation across the two languages, thereby allowing the exploration of cross-language phonological influences. Each participant completed two sessions of letter-naming tasks. In one session, seven phonologically similar letters were randomly repeated either in single-language blocks or in alternate-language blocks. In the other session, seven phonologically dissimilar letters were similarly manipulated. The results indicated local inhibition, reflected by switch costs and global inhibition, reflected by mixing costs. Reversed language dominance, another indicator of global inhibition, was not observed. However, there was a tendency for larger global inhibition to be applied to the more dominant language. Moreover, there was significantly faster naming for phonologically similar letters compared to dissimilar ones, suggesting a facilitation effect for both English and German, irrespective of whether letter naming occurred in single- or alternate-language blocks. These findings provided evidence for the role of inhibitory and facilitative mechanisms at the phonetic level, suggesting language-specific control in the bilingual brain and underscoring the complexity and dynamics of managing language control across multiple levels of processing.
This study is dedicated to achieving efficient active noise control in a supersonic underexpanded planar jet, utilizing control parameters informed by resolvent analysis. The baseline supersonic underexpanded jet exhibits complex wave structures and substantial high-amplitude noise radiations. To perform the active control, unsteady blowing and suction are applied along the nozzle inner wall close to the exit. Employing both standard and acoustic resolvent analyses, a suitable frequency and spanwise wavenumber range for the blowing and suction is identified. Within this range, the control forcing can be significantly amplified in the near field, effectively altering the original sound-producing energetic structure while minimizing far-field amplification to prevent excessive noise. A series of large-eddy simulations are further conducted to validate the control efficiency, demonstrating an over 10 dB reduction in upstream-propagated screech noise. It is identified that the present unsteady control proves more effective than steady control at the same momentum coefficient. The controlled jet flow indicates that the shock structures become more stable, and the stronger the streamwise amplification of the forcing, the more likely it is to modify the mean flow characteristics, which is beneficial for reducing far-field noise radiation. Spectral proper orthogonal decomposition analysis of the controlled flow confirms that the control redistributes energy to higher forcing frequencies and suppresses large-scale antisymmetric and symmetric modes related to screech and its harmonics. The findings of this study highlight the potential of resolvent-guided control techniques in reducing noise in supersonic underexpanded jets and provide a detailed understanding of the inherent mechanisms for effective noise reduction through active control strategies.
A novel theoretical model for bubble dynamics is established that simultaneously accounts for the liquid compressibility, phase transition, oscillation, migration, ambient flow field, etc. The bubble dynamics equations are presented in a unified and concise mathematical form, with clear physical meanings and extensibility. The bubble oscillation equation can be simplified to the Keller–Miksis equation by neglecting the effects of phase transition and bubble migration. The present theoretical model effectively captures the experimental results for bubbles generated in free fields, near free surfaces, adjacent to rigid walls, and in the vicinity of other bubbles. Based on the present theory, we explore the effect of the bubble content by changing the vapour proportion inside the cavitation bubble for an initial high-pressure bubble. It is found that the energy loss of the bubble shows a consistent increase with increasing Mach number and initial vapour proportion. However, the radiated pressure peak by the bubble at the collapse stage increases with decreasing Mach number and increasing vapour proportion. The energy analyses of the bubble reveal that the presence of vapour inside the bubble not only directly contributes to the energy loss of the bubble through phase transition but also intensifies the bubble collapse, which leads to greater radiation of energy into the surrounding flow field due to the fluid compressibility.