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The rise in the number of automated robotic kitchens accelerated the need for advanced food handling system, emphasizing food analysis including ingredient classification pose recognition and assembling strategy. Selecting the optimal piece from a pile of similarly shaped food items is a challenge to automated meal assembling system. To address this, we present a constructive assembling algorithm, introducing a unique approach for food pose detection–Fast Image to Pose Detection (FI2PD), and a closed-loop packing strategy. Powered by a convolutional neural network (CNN) and a pose retrieval model, FI2PD is adept at constructing a 6D pose from only RGB images. The method employs a coarse-to-fine approach, leveraging the CNN to pinpoint object orientation and position, alongside a pose retrieval process for target selection and 6D pose derivation. Our closed-loop packing strategy, aided by the Item Arrangement Verifier, ensures precise arrangement and system robustness. Additionally, we introduce our FdIngred328 dataset of nine food categories ranging from fake foods to real foods, and the automatically generated data based on synthetic techniques. The performance of our method for object recognition and pose detection has been demonstrated to achieve a success rate of 97.9%. Impressively, the integration of a closed-loop strategy into our meal-assembly process resulted in a notable success rate of 90%, outperforming the results of systems lacking the closed-loop mechanism.
Returns to currency carry and momentum compensate for the risk of global interest rate volatility (IRV), with risk exposures explaining 92% of the cross-sectional return variations. This unified explanation stems from its impact on foreign exchange intermediaries. An intermediary-based exchange rate model shows that a higher global IRV increases the uncertainty of future risk-taking and tightens current financial constraints. Position unwinding triggers loss of carry and momentum. Additional empirical results confirm this economic channel. Global IRV risk is also negatively priced in other currency strategies and momentum. The explanatory power is not driven by existing measures of uncertainty or intermediary constraints.
Breast cancer is a high-risk disease with a high mortality rate among women. Chemotherapy plays an important role in the treatment of breast cancer. However, chemotherapy eventually results in tumours that are resistant to drugs. In recent years, many studies have revealed that the activation of Wnt/β-catenin signalling is crucial for the emergence and growth of breast tumours as well as the development of drug resistance. Additionally, drugs that target this pathway can reverse drug resistance in breast cancer therapy. Traditional Chinese medicine has the properties of multi-target and tenderness. Therefore, integrating traditional Chinese medicine and modern medicine into chemotherapy provides a new strategy for reversing the drug resistance of breast tumours. This paper mainly reviews the possible mechanism of Wnt/β-catenin in promoting the process of breast tumour drug resistance, and the progress of alkaloids extracted from traditional Chinese medicine in the targeting of this pathway in order to reverse the drug resistance of breast cancer.
The relationship of a diet low in fibre with mortality has not been evaluated. This study aims to assess the burden of non-communicable chronic diseases (NCD) attributable to a diet low in fibre globally from 1990 to 2019.
Design:
All data were from the Global Burden of Disease (GBD) Study 2019, in which the mortality, disability-adjusted life-years (DALY) and years lived with disability (YLD) were estimated with Bayesian geospatial regression using data at global, regional and country level acquired from an extensively systematic review.
Setting:
All data sourced from the GBD Study 2019.
Participants:
All age groups for both sexes.
Results:
The age-standardised mortality rates (ASMR) declined in most GBD regions; however, in Southern sub-Saharan Africa, the ASMR increased from 4·07 (95 % uncertainty interval (UI) (2·08, 6·34)) to 4·60 (95 % UI (2·59, 6·90)), and in Central sub-Saharan Africa, the ASMR increased from 7·46 (95 % UI (3·64, 11·90)) to 9·34 (95 % UI (4·69, 15·25)). Uptrends were observed in the age-standardised YLD rates attributable to a diet low in fibre in a number of GBD regions. The burden caused by diabetes mellitus increased in Central Asia, Southern sub-Saharan Africa and Eastern Europe.
Conclusions:
The burdens of disease attributable to a diet low in fibre in Southern sub-Saharan Africa and Central sub-Saharan Africa and the age-standardised YLD rates in a number of GBD regions increased from 1990 to 2019. Therefore, greater efforts are needed to reduce the disease burden caused by a diet low in fibre.
To investigate the association between the Metabolic Score for Visceral Fat (METS-VF) and risk of type 2 diabetes mellitus (T2DM) and compare the predictive value of the METS-VF for T2DM incidence with other obesity indices in Chinese people. A total of 12 237 non-T2DM participants aged over 18 years from the Rural Chinese Cohort Study of 2007–2008 were included at baseline and followed up during 2013–2014. The cox proportional hazards regression was used to calculate hazard ratios (HR) and 95 % CI for the association between baseline METS-VF and T2DM risk. Restricted cubic splines were used to model the association between METS-VF and T2DM risk. Area under the receiver operating characteristic curve (AUC) analysis was used to evaluate the ability of METS-VF to predict T2DM incidence. During a median follow-up of 6·01 (95 % CI 5·09, 6·06) years, 837 cases developed T2DM. After adjusting for potential confounding factors, the adjusted HR for the highest v. lowest METS-VF quartile was 5·97 (95 % CI 4·28, 8·32), with a per 1-sd increase in METS-VF positively associated with T2DM risk. Positive associations were also found in the sensitivity and subgroup analyses, respectively. A significant nonlinear dose–response association was observed between METS-VF and T2DM risk for all participants (Pnonlinearity = 0·0347). Finally, the AUC value of METS-VF for predicting T2DM was largest among six indices. The METS-VF may be a reliable and applicable predictor of T2DM incidence in Chinese people regardless of sex, age or BMI.
The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case–control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a seventy-eight-item semi-quantitative FFQ. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem MS. Multivariate conditional logistic regression was used to estimate OR and 95 % CI. Restricted cubic splines (RCS) were plotted to evaluate the dose–response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the OR of the highest quartile were 0·45 (95 % CI 0·29, 0·71, Ptrend = 0·001) for VD dietary intake and 0·26 (95 % CI 0·11, 0·60, Ptrend = 0·003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0·02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0·02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.
We have proposed and experimentally demonstrated a novel scheme for efficient mid-infrared difference-frequency generation based on passively synchronized fiber lasers. The adoption of coincident seeding pulses in the nonlinear conversion process could substantially lower the pumping threshold for mid-infrared parametric emission. Consequently, a picosecond mid-infrared source at 3.1 μm was prepared with watt-level average power, and a maximum power conversion efficiency of 77% was realized from pump to down-converted light. Additionally, the long-term stability of generated power was manifested with a relative fluctuation as low as 0.17% over one hour. Thanks to the all-optical passive synchronization and all-polarization-maintaining fiber architecture, the implemented laser system was also featured with simplicity, compactness and robustness, which would favor subsequent applications beyond laboratory operation.
Cognitive decline in advanced age is closely related to dementia. The trajectory of cognitive function in older Chinese is yet to be fully investigated. We aimed to investigate the trajectories of cognitive function in a nationally representative sample of older people living in China and to explore the potential determinants of these trajectories.
Methods:
This study included 2,038 cognitively healthy persons aged 65–104 years at their first observation in the Chinese Longitudinal Healthy Longevity Survey from 2002 to 2014. Cognitive function was measured using the Chinese version of the Mini-Mental State Examination (MMSE). Group-based trajectory modeling was used to identify potential heterogeneity of longitudinal changes over the 12 years and to investigate associations between baseline predictors of group membership and these trajectories.
Results:
Three trajectories were identified according to the following types of changes in MMSE scores: slow decline (14.0%), rapid decline (4.5%), and stable function (81.5%). Older age, female gender, having no schooling, a low frequency of leisure activity, and a low baseline MMSE score were associated with the slow decline trajectory. Older age, body mass index (BMI) less than 18.5 kg/m2, and having more than one cardiovascular disease (CVD) were associated with the rapid decline trajectory.
Conclusion:
Three trajectories of cognitive function were identified in the older Chinese population. The identified determinants of these trajectories could be targeted for developing prevention and intervention strategies for dementia.
The study of the petrogenesis of some magmatic rocks with special geochemical attributes provides effective information for us to explore the deep geodynamic background of their formation. A series of granitic porphyry dykes have been found in the mélange zone of the Asa region in southern Tibet, whose genesis may be closely related to the evolution of the Meso-Tethyan Ocean. Regional geodynamic evolution is investigated by whole-rock geochemical analysis, zircon U–Pb dating and Lu–Hf isotopic analysis of two porphyritic granites. The Asa porphyritic granites have high SiO2 (74.29–78.65 wt %) and alkalis (Na2O + K2O = 6.51–9.35 wt %) contents, and low Al2O3 (11.60–14.51 wt %), CaO (0.04–0.19 wt MgO (0.01–0.10 wt %) contents. They are enriched in Zr, Nb, Ce, Y and Hf and depleted in Ti, Ba, Sr and P, consistent with A-type granites. The samples are relatively rich in LREEs, with LREE/HREE ratios of 1.73–3.04. They display negative Eu anomalies (Eu/Eu* = 0.24–0.28) and obvious Ce anomalies in some samples. Zircon U–Pb analyses show that the porphyritic granites formed in late Early Cretaceous time, 107.4 to 105.5 Ma. Zircon εHf(t) values are in the range of 6.9 to 12.0. These data indicate that the porphyritic granites were sourced from interaction between mantle-derived and juvenile lower crust-derived melts, with the addition of oceanic sediment-derived melts. This occurred when the subducting Bangong–Nujiang oceanic crust split to create a slab window. Rising asthenosphere triggered re-melting of lower crust basalts, resulting in the formation of the late Early Cretaceous A-type granites around Asa.
To evaluate the effects of gestational weight gain (GWG) in the first trimester (GWG-F) and the rate of gestational weight gain in the second trimester (RGWG-S) on gestational diabetes mellitus (GDM), exploring the optimal GWG ranges for the avoidance of GDM in Chinese women.
Design:
A population-based prospective study was conducted. Gestational weight was measured regularly in every antenatal visit and assessed by the Institute of Medicine (IOM) criteria (2009). GDM was assessed with the 75-g, 2-h oral glucose tolerance test at 24–28 weeks of gestation. Multivariable logistic regression was performed to assess the effects of GWG-F and RGWG-S on GDM, stratified by pre-pregnancy BMI. In each BMI category, the GWG values corresponding to the lowest prevalence of GDM were defined as the optimal GWG range.
Setting:
Southwest China.
Participants:
Pregnant women (n 1910) in 2017.
Results:
After adjusting for confounders, GWG-F above IOM recommendations increased the risk of GDM (OR; 95 % CI) among underweight (2·500; 1·106, 5·655), normal-weight (1·396; 1·023, 1·906) and overweight/obese women (3·017; 1·118, 8·138) compared with women within IOM recommendations. No significant difference was observed between RGWG-S and GDM (P > 0·05) after adjusting for GWG-F based on the previous model. The optimal GWG-F ranges for the avoidance of GDM were 0·8–1·2, 0·8–1·2 and 0·35–0·70 kg for underweight, normal-weight and overweight/obese women, respectively.
Conclusions:
Excessive GWG in the first trimester, rather than the second trimester, is associated with increased risk of GDM regardless of pre-pregnancy BMI. Obstetricians should provide more pre-emptive guidance in achieving adequate GWG-F.
Mineral resource extraction has frequently caused social tensions in China. This research examines the reactive and pre-emptive strategies used by the Chinese state to cope with resource conflicts. Based on extensive fieldwork in multiple mining areas, we find that the Chinese local state actively mediates between the mining sector and local citizens, and skilfully suppresses collective protests. More importantly, it pre-emptively intervenes in dispute-prone processes and redistributes resource wealth to create vested interests and mitigate popular grievances. We argue that the active state intervention in resource conflicts in China is driven by the party-state's tight control of local officials, which prevents local capture by resource interests, and enabled by the party-state's deep reach into society, which allows grassroots governments to negotiate between conflicting interests and mobilize resources towards conflict resolution.
Ionization-induced electron injection in laser wakefield accelerators, which was recently proposed to lower the laser intensity threshold for electron trapping into the wake wave, has the drawback of generating electron beams with large and continuous energy spreads, severely limiting their future applications. Complex target designs based on separating the electron trapping and acceleration stages were proposed as the only way for getting small energy-spread electron beams. Here, based on the self-truncated ionization-injection concept which requires the use of unmatched laser–plasma parameters and by using tens of TW laser pulses focused onto a gas jet of helium mixed with low concentrations of nitrogen, we demonstrate single-stage laser wakefield acceleration of multi-hundred MeV electron bunches with energy spreads of a few percent. The experimental results are verified by PIC simulations.
The relationship between climate, crop growth and crop yield is complicated. This study aimed to determine the ratio of CO2–C emission to grain yield, the field treatments were initiated in 2003, but the measurements for this analysis were collected during the summer maize-growing seasons of 2011 and 2012 in the North China Plain. The experiment showed that conventional tillage with straw application significantly increased grain yield and the ratio of CO2–C emission to grain yield of summer maize. The mean soil CO2–C emission rate with no tillage was significantly lower than that when conventional tillage was used; however, straw application significantly increased the soil CO2–C emission rate, irrespective of whether tillage was performed or not. This was mainly because straw application changed the soil total porosity and organic carbon content. In conclusion, the results of this study support the hypothesis that the ratio of CO2–C emission to grain yield in the North China Plain can be increased by straw application, whereas no tillage decreases this ratio.
Many studies have suggested that folate-related one-carbon metabolism-related nutrients may play a role in certain cancer risks, but few studies have assessed their associations with the risk for nasopharyngeal carcinoma (NPC). In this study, we investigated the association between four folate-related one-carbon metabolism-related nutrients (folate, vitamin B6, vitamin B12 and methionine) and NPC risk in Chinese adults. A total of 600 patients newly diagnosed (within 3 months) with NPC were individually matched with 600 hospital-based controls by age, sex and household type (urban v. rural). Folate, vitamin B6, vitamin B12 and methionine intakes were measured using a validated seventy-eight-item FFQ. A higher dietary folate or vitamin B6 intake was associated with a lower NPC risk after adjusting for potential confounders. The adjusted OR of NPC for quartiles 2–4 (v. 1) were 0·66 (95 % CI 0·48, 0·91), 0·52 (95 % CI 0·37, 0·74) and 0·34 (95 % CI 0·23, 0·50) (Ptrend<0·001) for folate and 0·72 (95 % CI 0·52, 1·00), 0·55 (95 % CI 0·39, 0·78) and 0·44 (95 % CI 0·30, 0·63) (Ptrend<0·001) for vitamin B6. No significant association with NPC risk was observed for dietary vitamin B12 or methionine intake. The risk for NPC with dietary folate intake was more evident in the participants who were not exposed to toxic substances than in those who were exposed (Pinteraction=0·014). This study suggests that dietary folate and vitamin B6 may be protective for NPC in a high-risk population.
The ternary compound of AlCu4Y was synthesized by melting under argon atmosphere in the arc furnace. High-quality X-ray powder diffraction data of AlCu4Y have been collected using a Rigaku SmartLab X-ray powder diffractometer. The Rietveld refinement results of the X-ray diffraction pattern for the AlCu4Y compound showed that the AlCu4Y is the hexagonal structure, space-group P6/mmm (No. 191) with a = 5.0658(1) Å, c = 4.1569(1) Å, V = 92.38 Å3, Z = 1, and the density is 6.66 g cm−3, and the intensity ratio RIR is 1.96.
Countries endowed with rich natural resources such as fuels and minerals often fall behind in human development. Does resource endowment hamper human capital development in China, a country that hosts rich resources in many of its regions? Through cross-regional and longitudinal statistical analysis and field research in selected mining areas, this study finds that resource dependence reduces government expenditure on human capital-enhancing public goods including education and health care. The local economic structure and reduced demand for labour, the shifting of government responsibilities onto mining enterprises, and the myopia of local residents and officials all discourage the local governments in resource-rich regions from investing in human capital.
A new quaternary compound PrAlFeNi3 was synthesized and studied by means of X-ray powder diffraction technique. The powder pattern of PrAlFeNi3 was indexed and refined, giving a hexagonal structure, space group P6/mmm (No. 191) with the CaCu5 structure type, a = 5.1132(2) Å, c = 4.0737(1) Å, V = 92.19 Å3, Z = 1, ρx = 7.20 g cm−3, F30 = 173.61 (0.0054, 32) and RIR = 0.77.
The CeCo3Ni2 compound was synthesized by arc melting under argon atmosphere. High-quality powder X-ray diffraction (XRD) data of CeCo3Ni2 have been collected using a Rigaku SmartLab X-ray powder diffractometer. The refinement of the XRD pattern for the CeCo3Ni2 compound shows that the CeCo3Ni2 is a hexagonal structure, space group P6/mmm (No.191) with a = b = 4.9081(2) Å, c = 4.0034(2) Å, V = 83.52 Å3, Z = 1, and ρx = 8.6347 g cm−3. The Smith–Snyder FOM F30 = 112.7(0.0089, 30) and the intensity ratio RIR = 0.48.
In this paper, we investigate the Dirichlet eigenvalue problems of the poly-Laplacian with any order and the quadratic polynomial operator of the Laplacian. We give some estimates for lower bounds of the sums of their first k eigenvalues.
A new ternary compound Ho2AlGe3 was synthesized and studied by means of X-ray powder diffraction technique. The powder pattern of Ho2AlGe3 was indexed and refined, giving an orthorhombic structure, space group Pnma (No. 62) with the Y2AlGe3 structure type: a = 6.743 98(8) Å, b = 4.163 73(5) Å, c = 17.5834(2) Å, V = 493.74 Å3, Z = 4, ρx = 7.73 g cm−3, F30 = 202.7 (0.004, 37), and RIR = 1.21.