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Objective

To explore the treatment options and prognostic factors of vocal fold leukoplakia.

Methods

The study examined conservative and surgical treatment approaches, and analysed prognostic factors influencing vocal fold leukoplakia outcomes.

Results

In the conservative treatment group, lesion size (p = 0.035) and smoking (p < 0.001) were identified as independent factors influencing treatment outcomes. In the surgical treatment group, lesion size (p = 0.018) was identified as an independent factor affecting recurrence. There was no statistically significant difference in the effectiveness of conservative versus surgical treatment for patients with hyperplasia (p = 0.223), mild dysplasia (p = 0.634) and moderate dysplasia (p = 0.758).

Conclusion

Smoking and lesion size are key factors influencing the outcome of conservative treatment, while lesion size is a significant factor affecting recurrence in surgically treated patients. More importantly, conservative treatment should be prioritised for patients with moderate dysplasia and milder vocal fold leukoplakia.

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Retrospective analysis of 351 patients with vocal fold leukoplakia: impact of smoking, lesion size and histopathological grade on treatment outcomes

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Retrospective analysis of 351 patients with vocal fold leukoplakia: impact of smoking, lesion size and histopathological grade on treatment outcomes