This systematic review explores the psychosocial wellbeing of neurotypical (NT) women in intimate relationship with persons with Asperger's Syndrome (AS), and intervention models for such relationships. Over 20 pertinent scholarly databases were searched in April 2011. The initial search yielded 1,736 unique items. Articles were eligible if they were a peer-reviewed journal article or a peer-reviewed thesis investigating adult couple relationships where only one partner had AS. Ten studies were agreed by both reviewers to have met these final inclusion criteria. Utilising the National Health and Medical Research Council (NHMRC) guidelines the body of evidence comprising the final 10 studies was assessed to be of an overall grade D or ‘weak’. None of the studies included for final analyses were intervention studies.