A Systematic Review of Chemical Weed Management in Peanut (Arachis hypogaea) in the United States: Challenges and Opportunities

Abstract Herbicides are the primary tool for controlling weeds in peanut (Arachis hypogaea L.) and are crucial to sustainable peanut production in the United States. The literature on chemical weed management in peanut in the past 53 yr (1970 to 2022) in the United States was systematically reviewed to highlight the strengths and weaknesses of different herbicides and identify current research gaps in chemical weed management. Residual weed control in peanut is achieved mainly with dimethenamid-P, ethalfluralin, pendimethalin, and S-metolachlor. More recently, the use of the protoporphyrinogen oxidase inhibitor flumioxazin and acetolactate synthase inhibitors, such as diclosulam, for residual weed control in peanut has increased considerably. Postemergence broadleaf weed control in peanut is achieved mainly with acifluorfen, bentazon, diclosulam, imazapic, lactofen, paraquat, and 2,4-DB, while the graminicides clethodim and sethoxydim are the major postemergence grass weed control herbicides in peanut. Although several herbicides are available for weed control in peanut, no single herbicide can provide season-long weed control due to limited application timing, lack of extended residual activity, variability in weed control spectrum, and rotational restrictions. Therefore, effective weed management in peanut often requires herbicide mixtures and/or sequential application of preplant-incorporated, preemergence, and/or postemergence herbicides. However, the available literature showed a substantive range in herbicide efficacy due to variations in environmental conditions and flushes of weed germination across years and locations. Despite the relatively high efficacy of herbicides, the selection of herbicide-resistant weeds is another area of increasing concern. Future research should focus on developing new strategies for preventing or delaying the development of resistance and improving herbicide efficacy within the context of climate change and emerging constraints such as water shortages, rising temperatures, and increasing CO2 concentration.


Introduction
Peanut (Arachis hypogaea L.) is an important oilseed and cash crop in the United States.The United States is the fourth largest producer of peanut in the world with a market value of more than $1 billion (USDA-NASS 2022).Peanut production in the United States increased from 2,800 kg ha −1 in the 1970s to 4,600 kg ha −1 in 2021 (USDA-NASS 2022) due to improved cultivars and cultural practices, more effective pest management, and increased per capita consumption (Holbrook 2019).Although more-effective herbicides are available, weed interference remains a major constraint for peanut production in the United States despite continuous research efforts in weed science.Season-long weed interference can cause 60% to 80% peanut yield reduction through competition for light, water, and nutrients and decreased harvest efficiency (Everman et al. 2008a(Everman et al. , 2008b)).
Peanut has characteristics that make weed control challenging compared with other row crops such as cotton (Gossypium hirsutum L.), corn (Zea mays L.), or soybean [Glycine max (L.) Merr.].It has a low canopy, allowing weeds to be more competitive for light, particularly during the early stage of crop growth (Wilcut et al. 1995).Peanut also requires a long growing season (140 to 160 d) for development and maturity (Chaudhari et al. 2018), and residual herbicides registered for use in peanut do not provide season-long weed control, leading to heavy lateseason weed infestation (Grichar 2007).The prostrate growth habit of peanut, with its stems growing parallel to the soil, restricts cultivation to the early season (Boyer et al. 2011).Cultivation can also introduce wounds to the plant tissue, which can increase access for pathogens and disease incidence (Wilcut et al. 1995).Weed control could be accomplished by hand weeding, but this is expensive, time-consuming, laborious, and impractical under modern-day circumstances (Johnson et al. 2012a(Johnson et al. , 2012b)).Consequently, weed management in peanut is overwhelmingly achieved with herbicides, and research in the United States has focused primarily on chemical weed control.Although herbicides are not a complete solution to the complex weed management challenges in peanut production, they are effective and have contributed significantly to increased peanut yields (Gianessi and Reigner 2007).
Numerous studies have evaluated various herbicides for weed control in peanut in the United States.However, a systematic review of existing literature on this subject is lacking.The biology and management of weeds in peanut, including chemical weed control, was reviewed by Wilcut et al. (1995), but this review was published almost three decades ago.Since that publication, several herbicides such as acetochlor, carfentrazone, diclosulam, dimethenamid-P, flumioxazin, fluridone, fluazifop-P, imazapic, lactofen, pyroxasulfone, and S-metolachlor have been registered in peanut (Anonymous 2017(Anonymous , 2023;;Prostko et al. 2011).Considerable progress has been made in developing herbicides to increase the number of tools available for weed control in peanut, including the recent registration of one new herbicide mode of action (Group 12, fluridone) (Anonymous 2023).
No single herbicide application can provide sufficient weed control in all situations due to a narrow window of application, low residual activity, variability in weed control, and rotational restrictions.Therefore, effective weed control in peanut is generally obtained by using herbicide programs that consist of herbicide mixtures and sequential applications of preplant-incorporated or preemergence, early-postemergence, and/or late-postemergence herbicides (Chaudhari et al. 2018).Growers use a broad combination of preplant-incorporated, preemergence, and postemergence herbicides based on the weed community composition, dominant weed species, rotational restrictions, environmental conditions, and economic benefits (Leon et al. 2019).
In addition to the earlier review by Wilcut et al. (1995), Leon et al. (2019) provided an overview of sustainable weed management in peanut, but focused particularly on weed prevention, avoidance, monitoring, and suppression as parts of successful integrated weed management in peanut.The current paper presents a systematic review of weed management research in peanut in the United States in the last five decades, specifically focusing on chemical weed management methods.This review aims to compile existing literature and access the research progress and achievements in peanut chemical weed management, highlight the strengths and weaknesses of various herbicides used in peanut to assist in augmenting herbicide recommendations for research and extension, and identify current research gaps and prospects for future research.

Systematic Literature Search
The literature search was done using a four-step filtering process.
Step 1 The databases of Scopus, Web of Science, and Peanut Science (journal of the American Peanut Research and Education Society) covering 53 yr (from 1970to July 2022, accessed July 12, 2022) were searched using predefined search terms (Table 1).Peanut Science was included because it is currently not indexed in Scopus or Web of Science but publishes peer-reviewed results of peanut research.
Step 2 The total record (2,171 peer-reviewed articles) from the three databases was screened to identify each article's relevance for the review by refining the search terms based on exclusion criteria (Table 1).This resulted in a refined cohort of 555 peer-reviewed publications.
Step 3 The refined cohort of 555 peer-reviewed publications from the three databases was exported and combined in Excel, with the year of publication as rows and contents (journal, research focus, weeds studied, herbicides tested, study type [field, greenhouse, or laboratory], study location, number of site-years, research methods, and abstract) as columns.
Step 4 Duplicates (78 peer-reviewed publications) were removed, and the remaining publications (477) were further screened by two independent researchers for their relevance by reviewing the titles and abstracts.This resulted in 317 unique and relevant publications that were subsequently reviewed.Of the 317 publications reviewed, 245 (77%) focused on chemical weed management, while the remaining 72 (23%) focused on nonchemical weed management.Only the 245 peer-reviewed publications focused on chemical weed management are discussed in the current paper.To help the readers determine specific herbicide/weed efficacy data and associated publication, tables for each herbicide MOA and application method have been constructed (Tables 2-10).Discussions on nonchemical weed management are covered in the first part of this publication series (Daramola et al. 2023a).
Research progress and developments in chemical weed control over the years have led to significant changes in the herbicide options available for weed control in peanut.Wilcut et al. (1995) presented a historical perspective describing the herbicide changes that occurred between the late 1940s and early 1990s along with a list of herbicide registrations and cancellations.Except for an overview, we will not duplicate this information.Rather, we will discuss new developments in peanut weed control since that publication.Alachlor, benefin, chloramben, dinoseb, metolachlor, naptalam, naptalam plus dinoseb, pendimethalin, trifluralin, and vernolate are among the first group of herbicides evaluated for efficacy and peanut tolerance between the late 1940s and early 1980s (Wilcut et al. 1995).During this period, preplantincorporated applications of the dinitroaniline herbicides benefin, pendimethalin, and trifluralin (used only in Texas and Oklahoma and not in the U.S. Southeast region) or preemergence applications of the chloroacetamide herbicides alachlor and metolachlor were used to control annual grasses and small-seeded broadleaf weeds.Vernolate applied preplant incorporated provided effective control of yellow (Cyperus esculentus L.) and purple (Cyperus rotundus L.) nutsedge (Buchanan et al. 1982;Wilcut et al. 1995), while broadleaf weeds were controlled with the postemergence herbicides acifluorfen, bentazon, chloramben, dinoseb, dinoseb plus naptalam, and 2,4-DB (Wilcut et al. 1995).Dinoseb was identified as one of the most promising postemergence herbicides in peanut in early research and was used extensively for selective weed control, particularly for troublesome weeds species such as Florida beggarweed [Desmodium tortuosum (Sw.)DC.] and sicklepod [Senna obtusifolia (L.) Irwin & Barneby] until 1986, when dinoseb registration was cancelled due to toxicity issues (Wilcut et al. 1995).Similarly, toxicity or injury concerns have eliminated alachlor, benefin, chloramben, naptalam, and vernolate from U.S. peanut production.The removal of these herbicides encouraged the development and registration of safer herbicides such as bentazon, chlorimuron, ethalfluralin, fenoxaprop, imazethapyr, norflurazon, paraquat, pyridate, and sethoxydim between the late 1980s and early 1990s (Wilcut et al. 1995).Reviews on the use of these herbicides in peanut can be found elsewhere (Buchanan et al. 1982;Wilcut et al. 1995).The past two decades have also witnessed significant progress in chemical weed control in peanut with registration of more herbicides such as acetochlor, carfentrazone, diclosulam, dimethenamid-P, fluazifop-P, fluridone, flumioxazin, imazapic, lactofen, pyroxasulfone, and S-metolachlor (Table 2).However, there are still gaps and limitations in chemical weed control in peanut with the currently registered herbicides.

Soil-applied Herbicides
Soil-applied herbicides are used to provide residual weed control and prevent weed establishment.Residual weed control in peanut is achieved mainly with very-long-chain fatty-acid (VLCFA) inhibitors from the chloroacetamide chemical family (e.g., acetochlor, dimethenamid-P, pyroxasulfone, and S-metolachlor), mitosis inhibitors from the dinitroaniline chemical family (e.g., ethalfluralin and pendimethalin), and less frequently with the carotenoid inhibitor norflurazon from the pyridazinone chemical family.The use of the PPO inhibitor flumioxazin from the Nphenylphthalimide chemical family and ALS inhibitors from the triazolopyrimidine (e.g., diclosulam) and imidazolinone (e.g., imazapic, imazethapyr) chemical families for residual weed control have increased considerably.Likewise, the phytoene desaturase inhibitor fluridone has recently been registered for preemergence application in peanut (Anonymous 2017).
Chloroacetamides (Acetochlor, Dimethenamid-P, Pyroxasulfone, and S-metolachlor) The chloroacetamides acetochlor, dimethenamid-P, pyroxasulfone, and S-metolachlor are soil-applied herbicides that inhibit long-chain fatty-acid biosynthesis (Shaner 2014).They are applied preplant incorporated, preemergence, or in conjunction with postemergence herbicides in peanut to control annual grasses and small-seeded broadleaf weeds and provide suppression of nutsedge (Cyperus spp.) and large-seeded broadleaf weeds such as bristly starbur (Acanthospermum hispidum DC.), common ragweed (Ambrosia artemisiifolia L.), D. tortuosum, and S. obtusifolia (Basinger et al. 2021;Clewis et al. 2007;Grichar et al. 2000;Robinson et al. 2006;Wehtje and Brecke 2004).Incorporating these herbicides into the soil ensures activity in situations where preemergence applications may fail from the absence of irrigation or inadequate rainfall; however, compared with activated preemergence applications, control or suppression of some weeds is lower (Grichar et al. 2000).The microencapsulated formulation of acetochlor registered for use in peanut provides longer residual activity and higher crop safety than emulsifiable concentrate formulations (Anonymous 2010;Grichar et al. 2015).In general, most preemergence herbicide applications, such as S-metolachlor and acetochlor applied preemergence, in peanut require adequate rainfall or irrigation for activation and optimum efficacy.S-metolachlor (12:80 mixture of R-inactive and S-active stereoisomers formulation) was registered in 1997 and provides weed control efficacy similar to metolachlor (50:50 mixture of R and S stereoisomers formulation) in peanut (Grichar et al. 2001(Grichar et al. , 2008)).It is applied at lower rates (1.1 to 1.4 kg ha −1 ) due to a greater concentration of S-stereoisomers in the formulation (Anonymous 2004;O'Connell et al. 1998).

Web of Science
Peanut Science Total TS = ("weed" OR "weed management" OR "weed control" OR "herbicides" OR "cultural method" OR "mechanical method" OR "biological method" OR "integrated" AND "peanut" OR "Arachis hypogaea") Weed Science small-seeded broadleaf weeds with acetochlor and S-metolachlor is often <70% (Tables 3 and 4).Peanut growers generally do not observe >70% control of I. lacunosa and S. exaltata with S-metolachlor; however, Chaudhari et al. (2018) and Seale at al. (2020) observed >70% control, probably due to low weed pressure in the soil seedbank or because control was evaluated very early in the season (19 to 21 d after planting).Dimethenamid-P controls some weed species with efficacy similar to acetochlor and S-metolachlor; however, dimethenamid-P is less effective on Ipomoea spp., S. spinosa, and C. esculentus (Burke et al. 2002;Clewis et al. 2002;Robinson et al. 2006).The available literature showed that dimethenamid-P provides poor (0% to 67%) control of entireleaf morningglory (Ipomoea hederacea var.integriuscula A. Gray), ivyleaf morningglory [Ipomoea hederacea (L.) Jacq.],I. lacunosa, and S. spinosa in peanut (Tables 3 and 4).Although acetochlor, dimethenamid-P, and S-metolachlor provide good control of most annual grasses, they have limited activity on Texas panicum [Urochloa texana (Buckley) R. Webster; syn.: Panicum texanum Buckley], which can be problematic in peanut (Clewis et al. 2007;Grichar et al. 1994;Johnson et al. 2002).Both acetochlor and S-metolachlor applied preemergence provided <70% control of U. texana in irrigated strip-tillage peanut (Grichar et al. 1994;Johnson et al. 2002).Similarly, dimethenamid-P applied preemergence did not control U. texana compared with a nontreated control in strip-tillage peanut despite optimum activation with irrigation (Johnson et al. 2002).While these herbicides provide effective weed control, peanut injury, stunting, and delayed emergence can occur depending on the method, timing, and rate of application (Chaudhari et al. 2018;Grichar and Dotray 2012).Peanut injury is also influenced by environmental factors such as soil moisture, temperature, pH, and organic matter (Cardina and Swann 1988;Chaudhari et al. 2018).S-metolachlor has been observed to cause greater injury and growth suppression at higher rates under wet conditions (Basinger et al. 2021;Chaudhari et al. 2018).Variable peanut injury ranging from <5% to 33% was reported from preemergence application of S-metolachlor up to 1.40 kg ai ha −1 (Basinger et al. 2021;Chaudhari et al. 2018;Clewis et al. 2007;Grichar et al. 2008).Although various levels of peanut injury have been observed from chloroacetamide herbicides, yields were not negatively impacted, except at rates higher than label recommended (Chaudhari et al. 2018;Clewis et al. 2007;Grichar et al. 2015).In studies evaluating peanut tolerance to preemergence applications of S-metolachlor at 1.1, 1.4, and 2.8 kg ha −1 , Basinger et al. (2021) observed yield reduction (8.9%)only at the 2.6X (2.8 kg ha −1 ) recommended rate.
Pyroxasulfone is another chloroacetamide herbicide used to control grasses and small-seeded broadleaf weeds in peanut (Dotray et al. 2018;Eure et al. 2015) and is similar in activity to acetochlor, dimethenamid-P, and S-metolachlor.Pyroxasulfone has a similar weed control spectrum but has a higher specific activity, allowing for a much lower application rate compared with dimethenamid-P (Grichar et al. 2019).Peanut generally has good tolerance to pyroxasulfone; however, preemergence applications caused 8% to 18% early-season peanut stunting (Eure et al. 2015;Grichar et al. 2019;Prostko et al. 2011).Several factors, including rates, soil type, environmental conditions, and cultivars, may influence early-season stunting or injury, with greater stunting following preemergence applications in heavy soils under wet

Dinitroaniline (Ethalfluralin and Pendimethalin)
Dinitroaniline herbicides such as ethalfluralin and pendimethalin are Group 3 herbicides that block mitosis through inhibition of microtubule polymerization.These herbicides are readily absorbed by roots and emerging shoots and are commonly used to control annual grasses and small-seeded broadleaf weeds in peanut (Johnson and Mullinix 1999).Dinitroanilines have low water solubility (<1 ppm) and are moderately volatile and susceptible to photodegradation (Weber 1990).As such, these herbicides are usually incorporated with rainfall, irrigation, or mechanically to prevent loss via evaporation (Johnson and Mullinix 1999).They can also be applied preemergence, but results are inconsistent compared with control by preplant-incorporated applications (Brecke and Currey 1980;Johnson and Mullinix 1999).
Dinitroanilines do not provide adequate control of A. artemisiifolia, Cyperus spp., D. tortuosum, eclipta [Eclipta prostrata (L.) L.], Ipomoea spp., S. spinosa, S. obtusifolia, and tropic croton (Croton glandulosus L.) (Grichar and Colburn 1996;Scott et al. 2002;Wilcut et al. 1995).Grichar et al. (1994) found dinitroaniline herbicides were ineffective in controlling U. texana in conservation-tillage peanut production.Both ethalfluralin and pendimethalin applied preemergence or preplant incorporated provided poor early-season control of U. texana in non-irrigated minimum-tillage peanut (Wilcut et al. 1990b).Similarly, in irrigated strip-tillage peanut, U. texana control with pendimethalin was not >75%, while control in plots treated with ethalfluralin was not better compared with the untreated control (Johnson et al. 2002).The reduced efficacy of these dinitroaniline herbicides in conservation-tillage peanut was attributed to adsorption by cover crop residues and organic matter, resulting in greater concentration of the herbicide in the seed germination zone (Johnson et al. 2002).Peanut injury, expressed as stunting, swollen hypocotyls, and abnormal lateral root growth, has been observed with dinitroaniline herbicides (Johnson et al. 1997;Johnson and Mullinix 1999).The level of injury from these herbicides can vary depending on the method, timing, and rates of application (Johnson and Mullinix 1999;Johnson et al. 2011).Ethalfluralin and pendimethalin were reported to be more injurious to peanut when applied preplant incorporated than preemergence, and injury increased with increasing rate of application from 0.6 to 2.2 kg ai ha −1 for each herbicide (Johnson and Mullinix 1999).Similarly, applications of ethalfluralin and pendimethalin delayed until 3 wk after emergence caused significant injury and reduced peanut yield compared with preemergence applications (Johnson et al. 2011).Dinitroaniline injury can also be undetected until harvest, because the vegetative growth may appear unaffected, but injured plants often have large numbers of pegs and very few pods (Johnson et al. 2011).Peanut gynophores (pegs) form aboveground and grow downward to penetrate the soil surface (pegging), where they contact damaging levels of the herbicide at the soil surface.These herbicides block cell division in the developing peg, thus preventing the peg from penetrating the soil and forming the pod (Johnson et al. 1997).
Although injury has been observed, several studies, especially in conventional tillage systems, reported preplant-incorporated or preemergence applications of ethalfluralin, pendimethalin, and trifluralin do not affect peanut yield when used at the recommended application timings and rates (Brecke and Currey 1980;Dotray et al. 2003;Grichar and Colburn 1993;Johnson et al. 1997).In a 3-yr study, Grichar and Colburn (1993) observed that yield and grade of five runner peanut cultivars were not affected by preplant-incorporated application of ethalfluralin, pendimethalin, and trifluralin.Similarly, peanut yield was not affected by preplantincorporated application of ethalfluralin and pendimethalin at 0.67 to 1.68 kg ai ha −1 and trifluralin at 0.56 and 0.71 kg ai ha −1 in five runner-type cultivars.However, Johnson et al. (2011) showed that both ethalfluralin and pendimethalin have the potential to inhibit pod formation and reduce peanut yield in strip-tillage systems, especially when the application is delayed.Studies have also reported that cover crop debris present in strip-tillage systems can influence the availability of herbicide, which may cause the herbicide to be more injurious to peanut (Johnson et al. 2002;Weber 1990).The retention of cover crop residue in strip-tillage systems can increase soil-water content and cause cooler soil temperatures, which possibly resulted in higher peanut injury from the herbicides at ground cracking.
Weed Science a Efficacy range across all references listed from 0% to 100%, where 0 = no control, 100 = complete control.
(Table 5).It can be used to provide effective control of ALS inhibiting herbicide-resistant weeds, particularly A. palmeri (Grichar and Dotray 2013;Seale et al. 2020).Flumioxazin does not effectively control C. esculentus (Ducar et al. 2009;Grey et al. 2004), S. obtusifolia (Grey and Wehtje 2005;Johnson et al. 2010;Willingham et al. 2008), and wild poinsettia (Euphorbia heterophylla L.) (Grey et al. 2004), and annual grass control is inconsistent (Grichar and Colburn 1996).Flumioxazin selectivity in tolerant species and peanut is achieved through rapid metabolism (Yoshida et al. 1991).In a laboratory study evaluating differential tolerance of I. hederacea, S. obtusifolia, and peanut, Price et al. (2004) observed more rapid metabolism of root-absorbed [ 14 C]flumioxazin in peanut and S. obtusifolia (tolerant species) compared with I. hederacea (susceptible species).Peanut metabolism was three times faster than I. hederacea metabolism, with only 11% of the parent compound retained 72 h after treatment compared with 41% retained in I. hederacea at the same time point (Price et al. 2004).This suggests peanut metabolizes root-absorbed flumioxazin before any visible injury is observed.Price et al. (2004) also showed that peanut germination was not affected by the direct exposure of peanut seed to flumioxazin at field application rates.Flumioxazin injury characterized by stunting and leaflet discoloration was <30% when applied preemergence at recommended rates (Askew et al. 1999;Burke et al. 2002;Grey et al. 2004;Grey and Wehtje 2005;Hurdle et al. 2020;Teuton et al. 2004;Umphres et al. 2018;Wilcut et al. 2001).However, delaying application until germination initiation increases the risk of direct contact with emerged plants, which is highly injurious to peanut (Burke et al. 2002;Jordan et al. 2009a).Flumioxazin applied at 6, 8, and 10 d after planting caused significant peanut injury (20% to 59%) compared with applications at 0, 2, and 4 d after planting (0% to 29%) (Burke et al. 2002).
Peanut injury from flumioxazin is also influenced by soil organic matter and clay content (Leon and Tillman 2015).Planting depth and flumioxazin placement depth has also been shown to influence injury potential (Ferrell et al. 2005).Greater injury is also associated with cool weather or rainfall occurring during or soon after flumioxazin application due to increased absorption and decreased metabolism (Hurdle et al. 2020;Umphres et al. 2018;Wilcut et al. 2001).In studies conducted with three runner-type peanut cultivars, Wilcut et al. (2001) reported flumioxazin injury caused season-long reduction in peanut canopy, but yield was not adversely affected.Similarly, Burke et al. (2002) observed delayed peanut pod development due to injury from flumioxazin, but no reduction in peanut yield.Hurdle et al. (2020) reported yield reduction due to flumioxazin injury in one of three locations in a study conducted in North Carolina.At this site, injury of 50% to 67% was observed due to cool and wet conditions at the time of peanut emergence compared with <2% injury from the same studies at two other locations where environmental conditions were favorable for peanut emergence.
Heavy rainfall that results in splashing of flumioxazin-treated soil on peanut foliage can cause temporary injury (Grey et al. 2007).Generally, peanut injury from flumioxazin is transient, with recovery between 5 and 8 wk after treatment with no effect on peanut grade and pod yield regardless of flumioxazin application rate, timing, or peanut cultivar (Askew et al. 1999;Basinger et al. 2021;Ducar et al. 2009;Johnson et al. 2006;Main et al. 2005;Seale et al. 2020;Umphres et al. 2018;Wilcut et al. 2001).Despite preemergence activity, flumioxazin has relatively low soil persistence and does not have carryover concerns for rotation with corn, cotton, and soybean (Grey et al. 2002).
Sulfentrazone is another soil-applied PPO-inhibiting herbicide that has been evaluated but is no longer registered in peanut (Grey et al. 2007).Sulfentrazone applied preemergence or preplant incorporated provided effective control of many broadleaf weeds, including A. hispidum, A. palmeri, D. tortuosum, Ipomoea spp., and E. heterophylla (Tables 4 and 5).However, significant peanut injury and yield reduction from sulfentrazone was reported across the major peanut-growing regions (Grey et al. 2004;Grichar et al. 2006;Johnson and Mullinix 1994).Although sulfentrazone is effective for weed control, the unacceptable injury and rotational concerns, especially under coarse-textured soil typical of most peanut-growing regions, resulted in the registration being cancelled for peanut (Grey and Wehtje 2005;Grichar et al. 2006).

Foliar-applied Broadleaf Herbicides
Postemergence broadleaf weed herbicides are critical for successful weed management programs in peanut.Control of late-emerging broadleaf weeds and those that escape early-season control from soil-applied herbicides is critical to maintaining good yields and proper harvesting (Everman et al. 2006;Wilcut et al. 1995).Peanut growers often make two or more postemergence broadleaf herbicide applications due to peanut's long growing season and continuous broadleaf weed germination (Chaudhari et al. 2018).Postemergence broadleaf weed control in peanut is achieved using bentazon and paraquat (photosynthetic inhibitors), acifluorfen and lactofen (PPO inhibitors), 2,4-DB (synthetic auxin), and chlorimuron, diclosulam, imazapic, and imazethapyr (ALS inhibitors).The application timing of these herbicides is important for effective control to ensure efficacy and reduce the need for multiple applications.Acifluorfen, bentazon, lactofen, and paraquat have contact activity and only kill tissues with which the spray comes into contact.Therefore, maximum weed control is achieved when applied to smaller weeds between peanut ground crack (GC) and 2 to 3 wk after GC (Grey et al. 2001;Jordan et al. 2003a).Conversely, chlorimuron, diclosulam, imazapic, imazethapyr, and 2,4-DB have systemic activity, and weed size is not as critical, as the herbicide is absorbed and translocated to meristematic tissues, killing underground structures (Dotray and Keeling 1997;Everman et al. 2006).

Photosynthetic Inhibitors (Bentazon and Paraquat)
Bentazon kills susceptible species by blocking electron flow in PSII, inhibiting the production of NADPH þ H and ATP needed for CO 2 fixation in the light-independent reactions (Shaner 2014).The blockage of electrons also elicits massive radical production, and this severe oxidative stress causes membrane disruption and cellular breakdown.Affected plants show chlorosis followed by necrosis and rapid plant death.Bentazon applied postemergence controls several broadleaf weeds in peanut (Table 6) and has activity on C. esculentus (Grichar 1992).However, it lacks residual activity and is ineffective for postemergence control of Amaranthus spp., D. tortuosum, Ipomoea spp., and S. obtusifolia (Grey et al. 2001;Richburg et al. 1993a).Bentazon is often applied in mixture with chloroacetamide herbicides such as metolachlor and dimethenamid-P to provide residual control and with other postemergence herbicides such as acifluorfen, lactofen, paraquat, and 2,4-DB to improve control of broadleaf weeds and increase weed control spectrum (Grichar et al. 1994).Bentazon applied in tank mixture with acifluorfen provided >90% control of

Weed Science
A. artemisiifolia, C. album, C. glandulosus, and Ipomoea spp.(Wilcut 1991b) and >95% control of A. palmeri compared with <60% control from bentazon alone (Grichar 1997a).While the tank mixture of bentazon with residual or postemergence broadleaf herbicides increased weed control spectrum and provided a residual effect for an extended period, considerable injury to peanut can occur (Grichar et al. 2012;Jordan et al. 2003b).Grichar et al. (2012) reported 5% to 20% peanut injury with bentazon plus imazapic, while Jordan et al. (2003b) observed greater peanut injury with early postemergence application of bentazon plus acifluorfen and bentazon plus acifluorfen plus 2,4-DB.In addition, acifluorfen plus bentazon and acifluorfen plus bentazon plus 2,4-DB reduced yield by 200 and 150 kg ha −1 , respectively, when compared with a nontreated control in a 3-yr weed-free trial (Jordan et al. 2003b).Similarly, late postemergence application of bentazon plus acifluorfen reduced peanut yield by at least 23% compared with a weed-free control (Jordan et al. 1993).Wilcut (1991a) also observed up to 37% reduction in peanut yield with delayed application of bentazon plus acifluorfen until 4 wk after GC compared with application at GC.  Grey et al. (1995Grey et al. ( , 2001)); Richburg et al. (1993aRichburg et al. ( , 1993bRichburg et al. ( , 1996)) a Efficacy range across all references listed from 0% to 100%, where 0 = no control, 100 = complete control.
Paraquat is a nonselective postemergence herbicide commonly used in peanut production, particularly in the southeastern United States (Eason et al. 2020;Wilcut et al. 1995;Wehtje et al. 1991).Paraquat was demonstrated to be a suitable replacement for dinoseb for control of annual broadleaf weeds in peanut (Wilcut et al. 1995).It is rapidly absorbed into plant foliage, killing susceptible species by diverting electrons in PSI and the production of highly reactive oxygen species (Shaner 2014).It can be applied from peanut hypocotyl emergence until 28 d after emergence to control early-emerging weeds (Jordan et al. 2003a).Paraquat provides good to excellent control of several annual broadleaf weeds, including D. tortuosum, S. obtusifolia, and Ipomoea spp.(Table 7) in addition to its activity on grass weed species (Wilcut 1991b).However, it does not control A. hispidum, coffee senna [Senna occidentalis (L.) Link], S. spinosa, and smallflower morningglory [Jacquemontia tamnifolia (L.) Griseb.](Wilcut et al. 1990c(Wilcut et al. , 1995)).Paraquat lacks residual activity; therefore, subsequent herbicide applications are often required to maintain season-long weed control.While paraquat provides consistent control of several annual grass and broadleaf weeds prevalent in the southeastern United States, it causes peanut stunting and foliar injury characterized by chlorosis, necrosis, and bronzing.However, plants recover rapidly under good environmental conditions, and yield is not affected in most cases if it is applied before pegging and fruit development (Carley et al. 2009;Eason et al. 2020;Knauft et al. 1990;Wehtje et al. 1994).Conversely, studies conducted with Virginia peanut types showed paraquat may affect peanut grade by delaying maturity (Carley et al. 2009;Knauft et al. 1990).In addition, paraquat injury can interact with other stressors, resulting in significant yield reduction.Brecke et al. (1996) reported significant reduction in peanut yield when paraquat was applied to peanut with damage from thrips.Similarly, paraquat application after 28 d of peanut emergence increases the chances of significant yield reduction (Brecke et al. 1996;Johnson et al. 1993).When paraquat application was delayed until 2 wk after GC, A. artemisiifolia control was reduced by 30% and peanut yield by 1,200 kg ha −1 , with a consequent net loss of about $400 ha −1 compared with application at GC (Wilcut and Swann 1990).
Depending on weed community composition, paraquat is often combined with imazapic or S-metolachlor to increase residual activity (Carley et al. 2009;Grichar and Dotray 2012;Wehtje et al. 2000aWehtje et al. , 2000b)).Although tank mixtures of paraquat and residual herbicides can improve weed control, significant injury and stunting may occur (Eason et al. 2020;Grichar and Dotray 2013;Grichar et al. 2012).Eason et al. (2020) reported significant peanut stunting up to 25% with paraquat plus S-metolachlor compared with paraquat alone (6% to 15%).Paraquat is also commonly applied in tank mixture with other postemergence broadleaf herbicides such as bentazon and 2,4-DB to reduce foliar injury to peanut, improve control of larger weeds, and broaden the weed control spectrum (Eason et al. 2020;Price et al. 2020;Wehtje et al. 1992aWehtje et al. , 1992b)).Co-application of paraquat and 2,4-DB improved control of larger S. obtusifolia plants than paraquat applied alone (Wehtje et al. 1992b).Similarly, paraquat applied in tank mixture with bentazon controlled a broader spectrum of broadleaf weeds including such as A. hispidum, C. rotundus, common cocklebur (Xanthium strumarium L.), S. occidentalis, S. spinosa, and J. tamnifolia, (Table 7) and reduced foliar injury from paraquat compared with paraquat applied alone (Eason et al. 2019;Grey et al. 1995;Wehtje et al. 1992a;Wilcut et al. 1991bWilcut et al. , 1994a)).However, bentazon applied with paraquat can act as an antagonist by reducing the absorption of paraquat on the leaf surface, thereby reducing paraquat efficacy on certain species (Wehtje et al. 1992a).In greenhouse and field studies, bentazon reduced the efficacy of paraquat for the control of D. tortuosum, S. obtusifolia, and U. texana in peanut (Wehtje et al. 1992a).
Paraquat is not commonly used in the southwestern United States because peanut injury from paraquat applied during the hotter periods can significantly reduce peanut yield and grade characteristics (Knauft et al. 1990;Wilcut and Swann 1990;Wilcut et al. 1995).Likewise, paraquat alone or in mixture with bentazon or 2,4-DB is not a common herbicide program in the Virginia-North Carolina region because paraquat does not provide adequate control of A. artemisiifolia, C. album, C. glandulosus and spurred anoda [Anoda cristata (L.) Schltdl.] which are commonly found in the region (Wilcut et al. 1994a(Wilcut et al. , 1995)).

PPO Inhibitors (Acifluorfen, Carfentrazone, and Lactofen)
Acifluorfen and lactofen are used for postemergence control of annual broadleaf weeds in peanut.They are classified as diphenyl ether (cell membrane disrupter) that kill weeds rapidly by interfering with protoporphyrinogen IX oxidase synthesis and causing accumulation of protoporphyrin IX in the cytoplasm (Shaner 2014).This molecule reacts with light, resulting in the production of toxic singlet oxygen species, which deteriorate cell membranes.Acifluorfen and lactofen provide >70% control of several annual broadleaf weeds such as A. palmeri, A. spinosus, A. artemisiifolia, C. glandulosus, C. melo, and S. spinosa (Table 7).They also provide effective control of ALS herbicide-resistant weeds in peanut and rotated crops such as cotton and soybean especially, in the southwestern and Virgina-North Carolina peanut growing regions of the United States (Culpepper et al. 2006;Wise et al. 2009).Acifluorfen and lactofen do not have residual activity at the rate used postemergence in peanut, thus sequential applications are often required for season long weed control (Dotray et al. 2012;Wilcut et al. 1990a).Sequential application of lactofen provides better weed control than single application (Jordan et al. 1993;Sperry et al. 2017) but can cause reduction in peanut yield (Sperry et al. 2017;Wilcut 1991b).
The efficacy of acifluorfen and lactofen is influenced by weed size or stage of weed growth at the time of application (Wilcut and Swann 1990;Wilcut 1991aWilcut , 1991b)).For example, efficacy of acifluorfen and lactofen on E. prostrata decreased with delayed applications, as larger weeds (>10 cm) escaped control (Grichar 1997b).Lactofen controlled C. album 86% when applied at the cotyledon to 2-leaf stage, but control declined to 34% when C. album was 10-cm high (Wilcut 1991b).In the same study, lactofen controlled S. spinosa 87% to 95% and Ipomoea spp.83% to 86% when applied at the 2-leaf stage, but control declined to 0% when applications were made at the 3-to 7-leaf stages.
Acifluorfen and lactofen can cause reduced canopy growth and visible peanut injury characterized by leaf bronzing, cupping and crinkling of leaf margins, and necrotic spots/lesions.Plant recover within 2 to 4 wk after application, and yield penalties are rarely observed if applications are made before full seed fill (Chaudhari et al. 2018;Ferrell et al. 2013;Grichar 1994).However, yield reduction can occur with sequential applications and applications made later in the season, especially between the R5 (beginning seed) to R6 (full seed) growth stages (Grichar 1997a;Jordan et al. 1993;Sperry et al. 2017;Wilcut 1991b).Peanut yield was reduced by 49% with late postemergence application of acifluorfen plus bentazon and by 45% with sequential application of lactofen (Jordan et al. 1993).Wilcut et al. (1990b) reported 39% and 45% Weed Science reduction in peanut yield when application of acifluorfen plus bentazon and lactofen was delayed until 4 wk after GC compared with GC application, respectively.Other studies have reported similar yield reductions following sequential application of lactofen in peanut (Boyer et al. 2011;Grichar 1997b: Sperry et al. 2017;Wilcut et al. 1990b).Acifluorfen and lactofen are frequently tank mixed with 2,4-DB and crop oil concentrate (COC) (Ferrell et al. 2013;Grichar 1997b).Applying acifluorfen or lactofen with 2,4-DB increases efficacy, especially for ALS herbicide-resistant weeds, because 2,4-DB provides systemic activity.However, these herbicide treatments can cause visible peanut injury, although yield is not affected in most cases (Boyer et al. 2011;Ferrell et al. 2013).Application of lactofen with COC resulted in 48% injury and 10-d delay in peanut canopy closure (Boyer et al. 2011).
Carfentrazone is another PPO-inhibiting herbicide labeled for use in peanut.It has little or no residual effect but exhibits rapid contact activity, causing desiccation of susceptible weed species within hours of treatment and, consequently, plant death within days (Anonymous 2008(Anonymous , 2020)).Carfentrazone is used to control Ipomoea species in peanut (Grichar et al. 2021;Kharel et al. 2022), but only as a burndown treatment before planting (Anonymous 2008;Grichar et al. 2010).Carfentrazone has been shown to cause stunting and peanut injury ranging from 7% to 62% and significant yield reduction in various studies (Chaudhari et al. 2017;Dotray et al. 2010, Grichar et al. 2010, 2021;Kharel et al. 2022;Price et al. 2021).Injury from carfentrazone can be substantially greater than injury from lactofen and paraquat plus bentazon, which is often considered as unacceptable by peanut growers (Dotray et al. 2010;Grichar et al. 2010).Several factors, including rates and timing of application, planting dates, and environmental factors, can influence peanut stunting or injury from carfentrazone.Carfentrazone causes more severe injury to peanut when applied early season rather than late season (Dotray et al. 2010;Grichar et al. 2010).Dotray et al. (2010) reported greater peanut injury ranging from 14% to 19% following early postemergence (28 to 51 d after planting) application of carfentrazone at 27 and 36 g ai ha −1 compared with 6% to 8% injury from late postemergence (93 to 121 d after planting) application.Similarly, Grichar et al. ( 2010) reported greater peanut a Efficacy range across all references listed from 0% to 100%, where 0 = no control, 100 = complete control.
injury ranging from 7% to 52% following early postemergence (35 d after planting) application of carfentrazone at 30 and 40 g ai ha −1 compared with 9% to 16% injury from late postemergence (56 d after planting) application.Injury from carfentrazone at these application rates and timings resulted in as much as 22% reduction in peanut yield, but peanut grade characteristics were not affected (Grichar et al. 2010).Yield losses up 27% were observed with carfentrazone-ethyl plus a high surfactant oil concentrate at 75 and 90 d after planting as compared with the nontreated check (Price et al. 2021).Similarly, carfentrazone application during the pod-filling stage (4 wk before digging) caused 10% reduction in peanut yield, whereas yield was not affected when applied at 1 or 2 wk before digging (Chaudhari et al. 2017).This research suggests carfentrazone may be an appropriate herbicide for late-season weed control to reduce weed interference with peanut digging and inversion.
Carfentrazone plus pyroxasulfone has recently been labeled as a commercially available premixed herbicide combination for post emergence application in peanut (Anonymous 2020).Available literature showed that carfentrazone plus pyroxasulfone can control small-seeded annual broadleaf weeds, including ALS herbicide-resistant A. palmeri in peanut (Grichar et al. 2021).Amaranthus palmeri control with carfentrazone plus pyroxasulfone preemergence was at least 78% season-long, while postemergence applications were inconsistent (24% to 100%).Pendimethalin plus premixed carfentrazone plus pyroxasulfone controlled C. melo at least 80% late season.

Synthetic Auxin (2,4-DB)
The herbicide 2,4-DB is a selective systemic phenoxyalkanoic acid Group 4 herbicide registered for use in peanut throughout the growing season (Jordan 2004).Several troublesome broadleaf weeds, including A. palmeri, C. melo, S. obtusifolia, Ipomoea spp., T. portulacastrum, golden crownbeard [Verbesina encelioides (Cav.)Benth.& Hook.f. ex A. Gray], and X. strumarium, are controlled with 2,4-DB applied postemergence in peanut (Table 7).However, 2,4-DB rarely provides complete control of S. obtusifolia and X. strumarium with a single application (Wilcut et al. 1995).Phenoxy herbicides are generally toxic to broadleaf weeds or crops, but legumes such as peanut exhibit high tolerance to 2,4-DB, and significant foliar injury is rarely observed (Dotray et al. 2004;Faircloth and Prostko 2010).Tolerant legumes cannot convert the butyric acid side chain as readily as other broadleaf plants (Hawf and Behrens 1974).Peanut tolerance to 2,4-DB has also been attributed to reduced spray retention, absorption, and translocation and less beta-oxidation within plant tissue, resulting in less conversion to the phytotoxic secondary metabolite (2,4-D) (Hawf and Behrens 1974;Ketchersid et al. 1978).Earlier studies indicated that 2,4-DB was not readily absorbed by peanut leaves, was slowly metabolized to 2,4-D, and was not accumulated in the nut at harvest (Ketchersid et al. 1978).In contrast, 2,4-DB was rapidly absorbed and converted to 2,4-D and subsequently translocated to the apical region in redroot pigweed (Amaranthus retroflexus L.), a susceptible species, resulting in reduced growth and death of the plant (Ketchersid et al. 1978).Application of 2,4-DB is restricted within 60 d before peanut harvest.Peanut yield was not impacted when 2,4-DB was applied within recommended rates and timing (Baughman et al. 2002;Faircloth and Prostko 2010;Ferrell et al. 2013;Grichar et al. 1997;Jordan et al. 2003b;Lancaster et al. 2005c).In earlier studies, application of 2,4-DB at 0.95 kg ai ha −1 up to 62 d after planting reduced pod development in a Spanish cultivar, but yield was not reduced with sequential application at 0.45 kg ai ha −1 during pod fill (Ketchersid et al. 1978).However, peanut yield and grade characteristics were not adversely affected when 2,4-DB was applied at 0.45 kg ai ha −1 up to 120 d after planting in runner and Virginia market-type cultivars (Baughman et al. 2002;Grichar et al. 1997).Similarly, Jordan et al. (2003b) reported that 2,4-DB at 0.14 kg ai ha −1 did not adversely affect peanut pod yield and seed germination when applied at 3, 5, or 7 wk before digging.
The herbicide 2,4-DB is often applied in combination with other postemergence broadleaf weed herbicides such as acifluorfen, bentazon, lactofen, and paraquat to improve weed control spectrum (Burke et al. 2002;Jordan et al. 2007;Wilcut et al. 1994b).Application of 2,4-DB with these herbicides can also improve control of weeds larger than the recommended size for treatment with broadleaf herbicides (Ferrell et al. 2013;Jordan et al. 2003a).Application of 2,4-DB in tank mixture with acifluorfen plus bentazon improved the control of A. palmeri between 10-to 20-cm height (Ferrell et al. 2013).However, these herbicide treatments can cause visible peanut injury (Ferrell et al. 2013;Jordan et al. 2003b) and stunting manifested as reduced canopy width (Ferrell et al. 2013), but yield penalties are rarely observed (Baughman et al. 2002;Dotray et al. 2004;Ferrell et al. 2013).
Graminicides are often applied in mixture with broadleaf herbicides and other pesticides to reduce the number of application trips over the field, saving time and fuel and increasing the spectrum of weed control and overall weed management (Burke et al. 2004;Grichar et al. 2002;Holshouser and Coble 1990).However, this practice can affect weed control when the tank mix contains herbicides that are not compatible (Chahal et al. 2012b(Chahal et al. , 2013;;Lancaster et al. 2008).Efficacy of the graminicides clethodim and sethoxydim may be reduced when applied in tank mixture with broadleaf herbicides such as acifluorfen, bentazon, acifluorfen plus bentazon, phenoxyalkanoic acid, 2,4-DB, or herbicides that inhibit ALS such as imazapic and imazethapyr (Burke and Wilcut Weed Science 2003;Burke et al. 2004;Jordan 1995;York et al. 1993), due to reduced absorption, translocation, or metabolism (Ferreira et al. 1995).Weed species, weed size at the time of herbicide application, rates, adjuvants, and environmental conditions can affect the interaction between graminicides and broadleaf herbicides (Burke and Wilcut 2003;Jordan 1995).Chlorimuron antagonized clethodim for E. crus-galli and S. halepense control but U. platyphylla control with clethodim was not affected (Jordan 1995).In the same study, Jordan (1995) reported reduction in E. crus-galli and U. platyphylla control with fluazifop-P when applied in tank mixture with chlorimuron compared with fluazifop-P alone.Also, bentazon antagonized sethoxydim and clethodim efficacy for E. crus-galli, S. halepense, and U. platyphylla control (Jordan 1995).Imazapic in mixture with clethodim reduced clethodim efficacy on D. sanguinalis, E. indica, P. dichotomiflorum, and U. texana, but U. platyphylla was not affected (Burke et al. 2004).Imazapic applied 1 d before and up to 3 d after clethodim reduced efficacy of clethodim on P. dichotomiflorum and D. sanguinalis >30 cm in height (Burke et al. 2004).Similarly, imazapic applied 3 d before and up to 7 d after clethodim reduced E. indica control compared with clethodim alone (Burke et al. 2004).Burke and Wilcut (2003) showed imazapic did not affect absorption or translocation of clethodim in treated E. indica but antagonized imazapic efficacy by reducing the photosynthetic rate of E indica and therefore the sensitivity of ACCase to clethodim (Burke and Wilcut 2003).Bentazon and 2,4-DB tank mixed with clethodim reduced P. dichotomiflorum and U. platyphylla control compared with clethodim alone (Burke et al. 2004).In a similar study, U. platyphylla control with clethodim was <65% when applied in mixture with acifluorfen, acifluorfen plus bentazon, imazethapyr, imazapic, or lactofen (Grichar et al. 2002).Ammonium sulfate and other adjuvants can be tank mixed to alleviate the antagonistic effect of broadleaf herbicides on the efficacy of clethodim and sethoxydim (Burke et al. 2004;Jordan 1995).
Herbicides with Soil and Foliar Activity-ALS Inhibitors (Chlorimuron, Diclosulam, Imazapic, and Imazethapyr) The introduction of the ALS inhibitors diclosulam, chlorimuron, imazapic, and imazethapyr is one of the most important developments in the history of weed control in peanut production in the United States.These herbicides provide effective control of monocotyledonous and dicotyledonous weed species and exhibit residual activity for preventing weed seedling emergence and foliar activity for control of emerged weeds (Grey and Wehtje 2005;Grey et al. 2003).In addition to broad-spectrum weed control, considerable safety to peanut is achieved (Grey and Wehtje 2005).These features may explain the peanut growers' high reliance on these herbicides during the last 20 yr, which in fact favored increased selection pressure and subsequently the evolution of resistance in important and problematic species, including A. palmeri (Clewis et al. 2007;Everman et al. 2006).However, the application of these herbicides is limited by rotational restrictions when rotation to sensitive crops such as cotton is anticipated (Grichar et al. 1999).Numerous researchers have reported the weed control spectrum of ALS-inhibiting herbicides in peanut (Tables 9 and 10), as these continue to be the backbone of weed control in peanut.
Chlorimuron is labeled for late postemergence application in peanut and is primarily used to control D. tortuosum to prevent yield loss and harvest interference (Wehtje et al. 2000a(Wehtje et al. , 2000b;;Wilcut et al. 1994a).Chlorimuron is restricted to use only from 60 d after emergence to 45 d before peanut harvest (Johnson et al. 1992a(Johnson et al. , 1992b)).During this application window, chlorimuron absorption in peanut is minimal and readily metabolized (Wilcut et al. 1989).However, by 60 d after peanut emergence, D. tortuosum plants are often about 90 to 120 cm (Cardina and Brecke 1991), which is significantly larger than the 25-cm height recommended on the chlorimuron label (Anonymous 2009).The application restriction of chlorimuron was established based on peanut injury and yield reductions following early-season Table 8.Cumulative results on the efficacy of acetyl-CoA carboxylase inhibitors applied postemergence in peanut.

Weed species
Efficacy a applications in studies conducted using 'Florunner'-a nowobsolete cultivar that has been replaced by newer cultivars in the U.S. Southeast peanut-growing region (Wilcut et al. 1989).However, chlorimuron can cause peanut injury even when applied at the recommended timing (Wehtje and Grey 2004).Reduction in peanut growth has been reported following chlorimuron application at the recommended timing, although no consistent reduction in peanut yield was observed (Johnson et al. 1992b;Prostko et al. 2009).However, studies conducted with newer cultivars such as 'Georgia-06G' and 'Tifguard' indicated 7% to 11% peanut yield reduction following chlorimuron application at 60 to 99 d after emergence, which is within the recommended window for application (Prostko et al. 2012).
Similarly, Grichar and Dotray (2010) in one of two trials, observed significant yield reduction in 'Tamrun 96' peanut cultivar following chlorimuron application at 60 to 95 d after peanut emergence.Additionally, incidence of tomato spotted wilt virus (TSWV) caused by thrips moving from dying weeds was reported following chlorimuron application in 'AP-3', 'Georgia-02C', and 'Georgia Green' peanut cultivars in 15 field trials in Georgia (Prostko et al. 2009).
It is also noteworthy that the recommended window of chlorimuron application is later than the 4-to 6-wk critical period of D. tortuosum control in peanut (Hauser et al. 1975).This indicates that an irreversible yield reduction is expected, even if chlorimuron controls D. tortuosum late in the growing season.Wehtje et al. (2000a) showed late-season control with chlorimuron after significant early-season interference did not improve peanut yield but resulted in a significant reduction in net return.Research conducted to evaluate the possibility of applying chlorimuron earlier than 60 d after peanut emergence showed that peanut cultivars such as 'AT 201' and Georgia Green exhibited acceptable tolerance to chlorimuron applied early in the growing season in three of four trials (Wehtje and Grey 2004).In that study, peanut yield reduction from early-season application of chlorimuron was observed only in one of four trials associated with plant stress, which suggests that chlorimuron possesses yield-reducing risk only when the crop has been stressed by other factors (Wehtje and Grey 2004).Differences in TSWV tolerance among cultivars may also be a confounding factor in accessing tolerance to chlorimuron.In another study, Johnson et al. (2010) reported better D. tortuosum control and greater yield in 'C99R' and Georgia Green peanut a Efficacy range across all references listed from 0% to 100%, where 0 = no control, 100 = complete control.
Chlorimuron can be applied in tank mixture with other lateseason herbicides, especially 2,4-DB.The interaction of chlorimuron and co-applied herbicides may be beneficial or detrimental to crop safety and weed control depending on the herbicide, application timing, and weed species (Wehtje et al. 1993).The tank mixture of chlorimuron and 2,4-DB improved the control of D. tortuosum, Ipomoea spp., and S. obtusifolia, but peanut injury was not affected (Wehtje et al. 1993).In the same study, a tank mixture of chlorimuron and 2,4-DB improved peanut yield when applied at 11 wk after planting, but yield was reduced when the tank mix was applied at 7 wk after planting (Wehtje et al. 1993).
Diclosulam is a triazolopyrimidine sulfonanilide ALS-inhibiting herbicide (Bailey et al. 1999a).It is often used in peanut as a preplant-incorporated or preemergence treatment to provide broadleaf and perennial sedge weed control, but it can also be used early postemergence (Baily and Wilcut 2002;Grey and Wehtje 2005;Lancaster et al. 2007).Diclosulam provides broadspectrum weed control at a much lower recommended use rate (27 g ha −1 ) than other herbicides used in peanut, and it is less restrictive compared with other ALS inhibitors with respect to cotton rotational limitations (Anonymous 2000c;Brecke et al. 2002).The rotation interval for cotton following imazethapyr and imazapic is 18 mo but it is only 10 mo for diclosulam (Anonymous 2000c).Our systematic review of the literature showed that diclosulam applied preplant incorporated or preemergence provides >70% control of Amaranthus spp., A. artemisiifolia, A. hispidum, C. album, D. tortuosum, D. sanguinalis, E. prostrata, Ipomoea spp., nodding spurge [Chamaesyce nutans (Lag.)Small], S. spinosa, U. texana, V. encelioides, and E. heterophylla in peanut (Tables 4 and 9).However, it does not provide effective control of S. obtusifolia, a major problematic weed in peanut in the United States (Brecke et al. 2002;Grey and Wehtje 2005;Main et al. 2005).Also, control of annual grasses and C. esculentus with diclosulam is inconsistent (Baily and Wilcut 2002;Brecke et al. 2002;Grichar et al. 1999).Some studies reported >80% C. esculentus control with diclosulam applied preplant incorporated or preemergence (Baily and Wilcut 2002;Clewis et al. 2002;Grey et al. 2004;Price and Wilcut 2002;Price et al. 2002), whereas others observed <70% control (Brecke et al. 2002;Grey et al. 2001;Grichar et al. 1999;Price and Wilcut 2002).Variations in C. esculentus control with diclosulam are attributed mainly to differences in application rates, with greater control observed with increasing rate of application (Ducar-Tredaway et al. 2006;Grey et al. 2001;Grichar et al. 1999), and application method, with preplant-incorporated applications often resulting in more consistent control than preemergence applications (Grey and Wehtje 2005;Grey et al. 2001Grey et al. , 2004;;Grichar et al. 1999;Main et al. 2002).The efficacy of diclosulam applied preemergence depends on the availability of soil moisture from rainfall or irrigation to move the herbicide to the active zone of weed germination (Grey and Wehtje 2005;Grey et al. 2004;Main et al. 2002).Although diclosulam is mostly applied preplant incorporated or preemergence, research has indicated that timely postemergence applications can provide effective control of several problematic weeds in peanut (Brecke et al. 2002;Everman et al. 2006;Lancaster et al. 2007).Lancaster et al. (2007) reported good to excellent control of A. artemisiifolia, C. esculentus, C. nutans, and I. hederacea following a postemergence application of diclosulam at 3 wk after planting at 9, 13, 18, and 27 g ha −1 , but smooth pigweed (Amaranthus hybridus L.) and C. album control was <35%.Diclosulam applied early postemergence controlled A. palmeri at least 85%, whereas control was 75% with late postemergence application at 30 g ai ha −1 (Grichar 2007).Diclosulam applied postemergence at 4, 9, 13, or 27 g ai ha −1 controlled A. artemisiifolia 92% when applied within 7 wk after planting, whereas control was 89% with 13 and 27 g ai ha −1 rates and 63% to 66% with 4 and 9 g ai ha −1 rates when the application was delayed until 9 wk after planting (Everman et al. 2006).Regardless of application rate, I. hederacea control with diclosulam was reduced by >50% when applied at 7 to 9 wk after planting (8-to 10-leaf stage) as compared with early application at 5 wk after planting (Everman et al. 2006).
Peanut cultivars exhibit good tolerance to diclosulam due to their ability to metabolize the herbicide (Bailey and Wilcut 2002;Grey et al. 2001;Grichar et al. 1999).However, minor, and transient injury characterized by necrosis and peanut stunting has been reported in Florida (Main et al. 2002;Teuton et al. 2004), Georgia (Grey et al. 2001(Grey et al. , 2003)), North Carolina (Bailey et al. 1999a(Bailey et al. , 2000;;Price et al. 2002), and south Texas (Grichar et al. 1999).Diclosulam injury resulted in reduced peanut root biomass and canopy diameter (Bailey et al. 2000;Grey et al. 2007), but yield and grade characteristics are generally not affected in popular Virginia-and runner-type cultivars (Bailey et al. 2000;Grey et al. 2007;Main et al. 2002Main et al. , 2005)).Main et al. (2002) reported peanut canopy width, yield, and percentage of extra-large kernels were not affected by diclosulam applied preplant incorporated at 18, 27, or 54 g ai ha −1 in peanut runner-type cultivars: Georgia Green, 'C99R', and 'MDR-98'.Similarly, Bailey et al. (2000) reported diclosulam applied preplant incorporated at 36 g ai ha −1 did not reduce peanut yields in eight Virginia-type cultivars.Diclosulam applied postemergence at 27 and 54 g ha −1 caused peanut injury ranging from 11% to 30%, but the injury was transient, and peanut yield was not affected (Everman et al. 2006) Imazapic and imazethapyr are Group 2 imidazolinone herbicides that kill susceptible weed species by inhibiting ALS,  (1994a, 1994b) a Efficacy range across all references listed from 0% to 100%, where 0 = no control, 100 = complete control.
Weed Science an enzyme involved in the biosynthesis of branched-chain amino acids (Senseman 2007).Imazapic and imazethapyr are registered in peanut for annual broadleaf weed and Cyperus spp.control (Richburg et al. 1995c).Imazethapyr applied preplant incorporated, preemergence, or postemergence and imazapic applied preemergence or postemergence are used to provide residual weed control in peanut in addition to their foliar activity (Richburg et al. 1994(Richburg et al. , 1995c;;Wilcut et al. 1996).Imazethapyr applied preplant incorporated or preemergence at rates ranging from 35 to 72 g ai ha −1 provides >70% control of A. cristata, A. hispidum, C. album, C. lanatus, C. melo, E. prostrata, Ipomoea spp., S. occidentalis, S. spinosa, X. strumarium, and Amaranthus species, including A. palmeri (Tables 4 and 9).Wilcut et al. (1991b) reported >90% control of A. cristata, E. prostrata, Ipomoea spp., and S. spinosa with preplant-incorporated and preemergence applications of imazethapyr at 71 g ai ha −1 .Similarly, postemergence application of imazethapyr provided >90% control of these weed species (Table 10), particularly when applied to small weeds within 10 d of weed emergence (Grey et al. 1995;Wilcut et al. 1994a).Regardless of application timing, imazethapyr does not provide good control of D. tortuosum and S. obtusifolia, the two most prevalent and troublesome weeds in peanut in the southeastern United States (Klingaman et al. 1992;Richburg 1995aRichburg , 1995bRichburg , 1996;;Wilcut et al. 1991bWilcut et al. , 1994a)).It also shows poor control of A. artemisiifolia, a prevalent weed species in North Carolina and Virginia peanut fields (York et al. 1995).Regardless of application method, A. artemisiifolia control with imazethapyr at 70 g ha −1 was not >67% even with sequential applications consisting of preplant incorporated before GC or preemergence followed by postemergence application (York et al. 1995).Similarly, imazethapyr did not control D. tortuosum and S. obtusifolia adequately with preplant-incorporated (Richburg et al. 1996)  The efficacy of imazethapyr for weed control in peanut is influenced by weed size; environmental factors; and method, timing, and rates of application (Dotray and Keeling 1997;Grichar et al. 1992;Richburg et al. 1993bRichburg et al. , 1996)).As discussed previously, tolerance to imazethapyr is based on differential metabolism among weed species.The amount of imazethapyr metabolized and, subsequently, the efficacy of the herbicide can vary with weed species and the site of uptake, which is influenced by the application method (Wilcut et al. 1991b).Grichar et al. (1992) reported a greater and more consistent C. esculentus and C. rotundus control with imazethapyr applied preplant incorporated compared with preemergence application.Similarly, York et al. (1995) observed a greater (>90%) and more consistent control of A. cristata and S. spinosa with imazethapyr applied preplant incorporated or preemergence compared with postemergence application (<60%).Environmental factors may account for the variation in the efficacy of imazethapyr following different application methods.Exposure to sunlight has been reported to degrade or alter the structure of imazethapyr (Basham and Lavy 1987), which may explain the reduced efficacy of the herbicide on Cyperus spp.when applied preemergence compared with preplant incorporated application.Furthermore, the efficacy of soil applied imazethapyr depend on the availability of moisture from rainfall or irrigation within a few days of application to activate the herbicide and enhance root absorption (Wilcut et al. 1994a).Also, water stress that enhances the development of thicker cuticles can reduce the uptake of foliar-applied herbicides (Shaner 1989), which may explain the reduced efficacy of imazethapyr applied postemergence compared with preplant-incorporated or preemergence applications.In addition, imazethapyr applied postemergence often does not kill weeds completely but rather causes distorted terminal growth and inhibits further weed development (York et al. 1995).However, postemergence application of imazethapyr has been shown to provide more consistent weed control in highly susceptible species such as A. hispidum (Wilcut et al. 1994a) and Ipomoea spp.(Grichar et al. 1992) compared with preplant-incorporated or preemergence applications.Postemergence application of imazethapyr provided >80% control of A. hispidum and Ipomoea spp.even at 0.5X the label rate (Richburg et al. 1995c).Poor weed control following postemergence application of imazethapyr may also be due to larger weed size (Wilcut et al. 1991b).Efficacy of translocated herbicides is influenced by weed size (York et al. 1995).Foliar absorption of imidazolinone herbicides is limited by the amount of herbicide that passes through the cuticle (Shaner 1989).Weed species such as A. cristata, C. album, S. spinosa, and S. occidentalis become tolerant of imazethapyr when larger after the 2-leaf growth stage (Wilcut et al. 1991a(Wilcut et al. , 1991b(Wilcut et al. , 1994b)).
Peanut has been shown to have excellent tolerance to imazethapyr due to its high capacity for metabolizing the herbicide (Cole et al. 1989;Grichar et al. 1997).Therefore, peanut injury from imazethapyr is usually minor and transient with no impact on yield and grade characteristics (Jordan et al. 2003b;Richburg et al. 1995c;Wilcut et al. 1991aWilcut et al. , 1991b;;York et al. 1995).Richburg et al. (1995c) observed only 10% peanut injury following postemergence application of imazethapyr at 72 g ha −1 .Peanut injury was not >11% in studies conducted with five runner-, three Virginia-, and four Spanish-type peanut cultivars in the southeastern and southwestern United States, although imazethapyr caused a slight reduction in canopy width in the Southeast (Richburg et al. 2006).Similarly, peanut injury from imazethapyr was not >11% even at 2X the label rate (140 g ha −1 ) (York et al. 1995).However, peanut stunting is associated with cool weather, high humidity, dew, or rainfall occurring during or soon after imazethapyr application due to increased absorption and slowed metabolism, but yield and grade are often not affected (Klingaman et al. 1992;Grichar 1997aGrichar , 1997b)).
Imazethapyr is often tank mixed with acifluorfen, bentazon, metolachlor, and 2,4-DB to increase the weed spectrum controlled and with paraquat to improve D. tortuosum and S. obtusifolia control (Grey et al. 1995;Grichar et al. 1992;Wilcut et al. 1991bWilcut et al. , 1994a)).However, the interaction of imazethapyr and co-applied herbicides may be additive, synergistic, or antagonistic on weed control depending on the targeted weed species and method of application (Grey et al. 1995;Grichar et al. 1992).Imazethapyr plus metolachlor as preemergence application improved control of Ipomoea spp.by 14% compared with imazethapyr applied alone (Wilcut et al. 1991b).Control of S. obtusifolia with imazethapyr applied early postemergence was not >24%, whereas imazethapyr plus paraquat provided at least 53% control (Wilcut et al. 1994a).

Herbicide-Resistance Issues
The spread of ALS herbicide-resistant and PPO herbicideresistant Amaranthus species has been prevalent since the 1990s (Heap 2023).The increased incidence of herbicide-resistant weeds is due mainly to the repeated use of herbicides from the same mechanisms of action not only within peanut fields but also in rotational crops and inadequate integration with other forms of weed control (e.g., cultural and mechanical).Most of the postemergence herbicides used in peanut, especially those with both residual and systemic activity, are ALS inhibitors, without which there are only a few alternatives.These herbicides are more susceptible to resistance selection due to their extended residual activity and active-site mutation (Saari et al. 2018).Repeated exposure of weeds to these herbicides led to increased selection pressure and the selection of resistant individuals.There are currently 159 weed species resistant to ALS-inhibiting herbicides, some of which seriously threaten peanut production (Berger et al. 2015;Heap 2023).Amaranthus palmeri resistance to ALSinhibiting herbicides was reported in 21 peanut-growing counties in Georgia (Wise et al. 2009) and 97% of the agronomic counties in Florida and North Carolina (Poirier et al. 2014;Sperry et al. 2017).Resistance to ALS-inhibiting herbicides in A. artemisiifolia has also been confirmed in peanut fields across the southeastern United States (Berger et al. 2015;Chandi et al. 2012).While there are more options for alternative weed control with herbicides from other mechanisms of action in corn, cotton, and soybean, only a few alternatives, particularly the PPO-inhibiting herbicides, are available in peanut.Although the PPO inhibitors such as acifluorfen, flumioxazin, and lactofen have improved the control of ALS herbicide-resistant weeds in peanut fields, there is a possibility of overusing this group of herbicides, which could result in resistance evolution and, consequently, limited options for weed control in peanut.Resistance to PPO-inhibiting herbicides has been reported in soybean (Heap 2023), suggesting that the use of PPO-inhibiting herbicides to manage ALS herbicide-resistant weeds in peanut might not be sustainable.The weed resistance situation is one of the reasons residual herbicides will continue to play a critical role in peanut weed management programs.Although paraquat remains an important option for weed control in peanut, as discussed previously, it is limited to use only within the first 28 d after peanut emergence.It is apparent, therefore, that growers cannot continue to rely only on chemical weed control, which will necessitate the integration of nonchemical weed control methods and a diverse and properly designed integrated weed management program in peanut production systems.

Synthesis, Conclusion, and Future Outlook
Although there is increased advocacy for integrated weed management, herbicides remain the dominant tool for weed management in peanut in the United States, as in most other field crops.Hence, the need to synthesize research results to understand the strengths, weaknesses, and effects of different herbicides to develop optimal, field-specific weed management programs.Several herbicides are available for weed control in peanut.However, our systematic review of the literature showed that no single herbicide application can provide sufficient weed control in all situations due to a narrow window of application, low residual activity, variability in weed control, and rotational restrictions.The chloroacetamide herbicides acetochlor, dimethenamid-P, and S-metolachlor and dinitroanilines such as ethalfluralin and pendimethalin provide residual control of many annual grasses and small-seeded broadleaf weeds in peanut but have limited activity on U. texana, especially in conservation-tillage peanut, which can be problematic.Flumioxazin, a PPO inhibitor, is particularly effective against troublesome broadleaf weeds such as D. tortuosum but is not effective on other important species, including C. esculentus and S. obtusifolia.The photosynthetic inhibitors bentazon and paraquat applied alone or in combination provide postemergence control of a wide range of annual grasses and broadleaf weeds, including dominant and troublesome species such as A. palmeri, D. tortuosum, S. obtusifolia, and Ipomoea spp., but lack residual activity and can only be applied within 28 d after peanut cracking.Similarly, the PPO inhibitors acifluorfen and lactofen provide excellent control of numerous annual broadleaf weeds and have improved control of ALS herbicide-resistant weeds in peanut fields.However, they do not provide residual effects at the rate used postemergence in peanut.The synthetic auxin 2,4-DB provides broadleaf weed control but also lacks residual activity and cannot be applied within 60 d before peanut harvest.Chlorimuron, an ALS inhibitor, provides late postemergence control of several broadleaf weeds, including D. tortuosum and S. obtusifolia, but cannot be applied until 60 d after crop emergence due to phytotoxicity to peanut.Other ALS inhibitors such as diclosulam, imazapic, and imazethapyr also provide effective control of many broadleaf, grassy, and sedge weed species.They have both residual and foliar activity and exhibit considerable safety to peanut.However, crop rotational restrictions must be considered before the application of these herbicides.Graminicides such as clethodim, fluazifop-P, and sethoxydim control annual and perennial grasses but do not control dicot weeds and lack residual activity.Due to these limitations, effective weed control in peanut often requires herbicide mixtures and/or sequential applications of preplant incorporated, preemergence, early postemergence, and/or late postemergence herbicides.Mixture of two or more herbicides in peanut often increases weed control and reduces the number of application trips over the field, saving time and fuel.However, this practice can affect weed control when the tank mix contains herbicides that are not compatible.Depending on the targeted weed species, weed size, application rates, and environmental factors, efficacy of graminicides on grass weed species can be reduced when applied in tank mixture with broadleaf herbicides such as acifluorfen, bentazon, acifluorfen plus bentazon, 2,4-DB, imazapic, and imazethapyr due to reduced absorption and translocation of graminicides.Adjuvants can alleviate the antagonistic effect of broadleaf herbicides on efficacy of graminicides, but the response can be inconsistent with the herbicide chemistry and weed species.Although there are numerous publications on weed control with herbicides in peanut in the United States, there is a substantive range in efficacy and weed spectrum controlled due to variations in environmental conditions and flushes of weed germination across years and locations.Most studies provided soil characteristics of the research location; however, in some cases, background information on weed pressure and detailed weather conditions before, at, and after herbicide application were not provided.This information is important to understand the differences in efficacy or peanut injury among the studies.
Despite the relatively high efficacy of herbicides, the evolution of herbicide-resistant weeds is another area of increasing concern.There are currently 159 weed species resistant to ALS-inhibiting herbicides, some of which seriously threaten peanut production (Berger et al. 2015;Heap 2023).The weed resistance situation highlights the need for greater stewardship of the active ingredients Daramola et al.: Weed control in peanut in USA 2 available as well as the need for investing in further research of nonchemical alternatives and new effective active ingredients.The available options for nonchemical weed control and their potential limitations in peanut are covered in the first part of this publication series (Daramola et al. 2023a).Although integrating herbicides with nonchemical weed management strategies and applying tank mixes of herbicides from various mode of actions is important to reduce the incidence of herbicide-resistant weeds, future research should focus on developing new strategies for preventing or delaying the development of resistance.For longterm effect, these strategies should be addressed within the context of climate change and emerging constraints such as water shortages, drought, and flooding and the effects of rising temperatures and increased CO 2 concentration on peanut-weed interactions and herbicide efficacy.

Table 1 .
Search terms and exclusion criteria used to identify relevant articles in the databases of Scopus, Web of Science, and Peanut Science (accessed: July 12, 2022).

Table 2 .
Mode of action (MOA), chemical family, application timings, and application rates of herbicides labeled for use in peanut since 1995.

Table 3 .
Cumulative results on efficacy of very-long-chain fatty-acid inhibitors applied preemergence in peanut.

Table 5 .
Cumulative results on the efficacy of seedling root growth (ethalfluralin and pendimethalin) and protoporphyrinogen oxidase (flumioxazin and sulfentrazone) inhibitors applied preemergence in peanut.

Table 6 .
Cumulative results on efficacy of photosynthesis inhibitors applied postemergence in peanut.

Table 9 .
Cumulative results on efficacy of acetolactate synthase inhibitors applied preemergence in peanut.

Table 10 .
Cumulative results on the efficacy of acetolactate synthase inhibitors applied postemergence in peanut.