Global Public Health Database Support to Population-Based Management of Pandemics and Global Public Health Crises, Part II: The Database

This two-part article examines the global public health (GPH) information system deficits emerging in the coronavirus disease 2019 (COVID-19) pandemic. It surveys past, missed opportunities for public health (PH) information system and operational improvements, examines current megatrend changes to information management, and describes a new multi-disciplinary model for population-based management (PBM) supported by a GPH Database applicable to pandemics and GPH crises.


Introduction
The 2019 novel coronavirus (SARS-CoV-2, 2019-nCoV) disease (COVID-19) has become the first pandemic of the 21 st century. Viral contributory causes include high virus shedding from upper respiratory tract secretions, symptomatic and pre-symptomatic virus transmission, reproduction ratio estimates up to 3.58, 1 little effective antiviral therapy, and no effective vaccine. Health system and community contributory causes include wide-spread community seeding through unrestricted air travel, inadequate implementation of nonpharmacologic control measures, limited contact tracing and viral diagnostic capabilities, overwhelmed clinical care facilities, and threat minimization by elected officials.
These contributory causes have drawn attention to potential remedies for pandemic management by public health (PH) authorities. Part I reviewed past missed opportunities for PH information systems and operational improvements, then examined important PH megatrends heralding future advances in pandemic management-evidence-based decision making, data literacy, ascent of PH information services, and ascent of remote management. Part I also reviewed the emergence of population-based management (PBM) of health crises. A multi-disciplinary model led by PH professionals is required to ensure data driven decisions can be made that reflect the PH needs and risks of local communities. This approach builds on the evolution of disaster management systems, which are used in most countries across the world, to regularly deal with local, state, national, and international crises. This article examines database requirements and modalities of functioning for PBM teams (PBMTs).

Digital Technology
Digital technologies may help perform a wide range of functions in pandemic management, as summarized in Table 1. 2 Health authorities in some countries have attributed their disease control successes to early adoption of such technology. [3][4][5] Nonetheless, major issues have arisen on data oversight, privacy, protection of personally identifiable health information, and redress for errors that implementing jurisdictions must confront. The scientific community has seen retractions of papers published in The Lancet and The New England Journal of Medicine due to post-publication concerns over provenance of proprietary data and inconsistencies from electronic health records. 6 This experience is cautionary about the importance of data source/origin, data audit trails, and oversight in managing such datasets.

Core Databases
Core Databases for PBM are characterized below in three overriding domains: 1. Background Information ( Recent emerging infectious diseases such as Ebola have prompted additional reviews of data needed for outbreak evaluation culminating in descriptions of an emerging science of outbreak analytics. 9,10 Taking into account the rate of global population growth, it was predicted in 2019 there would be 1.7MB data created every second for every person on Earth, bringing forth new data problems, "most notably where and how to store it." 9 With unprecedented movement of migrants and refugees from the Middle East, compounded by massive relocations of urban populations because of COVID-19, are only two entities that will impact data collection critical to future infectious diseases. The era of data-centric computing is here, rate of product change accelerating, storage options expanding, and already digital transformation has taken center stage as a key driver. Outbreaks, epidemics, and pandemics are driving streaming data, larger memory servers, video, artificial intelligence (AI), and machine learning (crucial to guarantee data security), and need for unprecedented "big data and analysis." 11 Multi-disciplinary AI questions to the proposed Global Public Health (GPH) Database will be increasingly common, as it should be in pandemics. All these demands require new training and professions. Cost effective and resilient Cloud storage infrastructure can adapt to rapid workload requirements such as transient or spiking demands of world-wide PBM requirements. With the advent of "fast and dense memory," the intelligent storage can be trained to be largely self-managing, responding to detect anything from race conditions or access to care changes. Harris concludes that the era of data-centric computing is here with the potential to bring top-priority to the demands of the proposed PBM system. 11 The Economist is more detailed in their assessment in managing future pandemics accelerated by population growth and globalization that have markedly increased the spread of infectious diseases: 12 • Data analysis can pinpoint outbreaks and reveal where they may unfold next. • Can show where people were moving within 24 hours, right from the initial outbreak, and could distribute that information widely, especially PBMTs. • Can take advantage of diverse skill sets in tracking new, lessunderstood pandemics, favoring the proposed multi-disciplinary focus of their teams to include: "physicians, veterinarians, ecologists, data scientists, epidemiologists, environmental health specialists, geographers, designers, and software developers," to help make sense of raw data and AI requests and critical mobility-related information. 12 • The WHO concludes that "working together with data firms and health agencies (ie, PBMTs) before a disaster strikes mitigates searching for data at the start of an outbreak, which is already too late, reiterating a multi-stakeholder collaboration archives more than working in isolation." 12 Artificial Intelligence in support of the GPH Database Expectations were high for AI to help fight COVID-19. However, before AI tools can make an impact, global collaboration and highquality data and model sharing are needed. Nature Machine Medicine emphasized that early warning and alerts, prediction and detection of outbreak of diseases, real-time disease monitoring world-wide, analysis and visualization of spreading trends, prediction of infection rate and infection trend, and rapid decision making to identify the effectiveness of management. 13 Other authors emphasize challenges that need to be addressed before AI can have a beneficial global impact. [14][15][16] They point out that a first challenge is knowing where to start with developing AI tools that can be most effective, which requires close cooperation with practitioners at the health care frontline, those that manage the PDMTs. The best solutions may involve adapting already validated systems rather than building new tools from scratch. Furthermore, Hu, et al described how clinical needs are evolving as the pandemic is moving through different stages, from early detection and anticipation, to containment and mitigation, and finally eradication. During these transitions, the specific types of AI models may need to change too. Ideally, the AI system itself becomes a smart, intelligent, and adaptive system. 13

Education and Training for PBM and the GPH Database
The origins of this pandemic can be attributed to climate change and the emergence of complex GPH crises such as climate extremes, biodiversity loss, emergencies of scarcity, rapid unsustainable urbanization, migrant and refugee surges, domestic and international terrorism, the civilianization of war and conflict, and the global rise of resistant antibiotics that have resulted in an unprecedented rise in direct and indirect mortality and morbidity, among others. 17 In 2019, The Tohuku Journal of Experimental Medicine recognized the emergence of complex GPH crises that are beyond the current decision-making and operational capabilities of traditional disaster management and its providers, most of who are community-level practitioners representing every discipline. The 1930s "disaster cycle" concept described a phase-related approach to meeting the strategic, operational, research, educational, and training components required of disasters; this presents an opportunity for the structured development of a Health Crisis Management Framework to oversee the phaserelated strategic and operational requirements for prevention, preparedness, response, recovery, and rehabilitation challenges of major GPH crises. 18 No longer will physicians, for example, Burkle © 2020 Prehospital and Disaster Medicine Table 2. (continued) Datasets and Visualizations Pre-Pandemic focus on the response phase alone. Future PBMTs will be trained across the entire disaster cycle. Operational knowledge on prevention and preparedness will lessen the number of victims more than any other action. The Japanese Editorial launched academic interest in training multi-disciplinary Health Care Crisis Managers and Scientists to fill the full-and part-time roles required of PBM, PBMTs, and those managing the GPH Database. For example, the university-centered CRIMEDIM (Research Center in Emergency and Disaster Medicine) in Navaro, Italy has worked diligently to offer both Masters and PhD degrees leading to training Health Crisis Managers and Scientists from many contributing disciplines to fill these proposed PBMT positions. A global effort is recommended post-COVID of multi-disciplinary educational programs to help prepare the potential PBMT and GPH Database experts that this study recommends.