%PDF-1.6
%
1 0 obj
<<
/AcroForm 2 0 R
/Metadata 3 0 R
/Pages 4 0 R
/StructTreeRoot 5 0 R
/Type /Catalog
>>
endobj
6 0 obj
<<
/CreationDate (D:20190702172101+05'30')
/Creator (Arbortext Advanced Print Publisher 9.1.405/W Unicode)
/ModDate (D:20220412202744+00'00')
/Producer (Acrobat Distiller 10.1.16 \(Windows\))
/Title (Should inverse agonists be defined by pharmacological mechanism or clinical effect?)
>>
endobj
2 0 obj
<<
/DA (/Helv 0 Tf 0 g )
/DR <<
/Encoding <<
/PDFDocEncoding 7 0 R
>>
/Font <<
/Helv 8 0 R
/ZaDb 9 0 R
>>
>>
/Fields []
>>
endobj
3 0 obj
<<
/Length 1855
/Subtype /XML
/Type /Metadata
>>
stream
2019-07-02T17:21:01+05:01
2021-03-18T02:08:35-07:00
Arbortext Advanced Print Publisher 9.1.405/W Unicode
2022-04-12T20:27:44+00:00
application/pdf
Should inverse agonists be defined by pharmacological mechanism or clinical effect?
Not for further distribution unless allowed by the License or with the express written permission of Cambridge University Press.
https://doi.org/10.1017/S1092852918001323
https://doi.org/10.1017/S1092852918001323 Published online by Cambridge University Press
uuid:5dec0e53-af49-4171-ad72-6620586390f1
uuid:1461cacf-bde2-463f-b69d-e138c6d55b8f
Acrobat Distiller 10.1.16 (Windows)
endstream
endobj
4 0 obj
<<
/Count 6
/Kids [10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R]
/Type /Pages
>>
endobj
5 0 obj
<<
/Type /StructTreeRoot
>>
endobj
7 0 obj
<<
/Differences [24 /breve /caron /circumflex /dotaccent /hungarumlaut /ogonek /ring /tilde 39
/quotesingle 96 /grave 128 /bullet /dagger /daggerdbl /ellipsis /emdash /endash
/florin /fraction /guilsinglleft /guilsinglright /minus /perthousand /quotedblbase /quotedblleft /quotedblright /quoteleft
/quoteright /quotesinglbase /trademark /fi /fl /Lslash /OE /Scaron /Ydieresis /Zcaron
/dotlessi /lslash /oe /scaron /zcaron 160 /Euro 164 /currency 166
/brokenbar 168 /dieresis /copyright /ordfeminine 172 /logicalnot /.notdef /registered /macron
/degree /plusminus /twosuperior /threesuperior /acute /mu 183 /periodcentered /cedilla /onesuperior
/ordmasculine 188 /onequarter /onehalf /threequarters 192 /Agrave /Aacute /Acircumflex /Atilde
/Adieresis /Aring /AE /Ccedilla /Egrave /Eacute /Ecircumflex /Edieresis /Igrave /Iacute
/Icircumflex /Idieresis /Eth /Ntilde /Ograve /Oacute /Ocircumflex /Otilde /Odieresis /multiply
/Oslash /Ugrave /Uacute /Ucircumflex /Udieresis /Yacute /Thorn /germandbls /agrave /aacute
/acircumflex /atilde /adieresis /aring /ae /ccedilla /egrave /eacute /ecircumflex /edieresis
/igrave /iacute /icircumflex /idieresis /eth /ntilde /ograve /oacute /ocircumflex /otilde
/odieresis /divide /oslash /ugrave /uacute /ucircumflex /udieresis /yacute /thorn /ydieresis]
/Type /Encoding
>>
endobj
8 0 obj
<<
/BaseFont /Helvetica
/Encoding 7 0 R
/Name /Helv
/Subtype /Type1
/Type /Font
>>
endobj
9 0 obj
<<
/BaseFont /ZapfDingbats
/Name /ZaDb
/Subtype /Type1
/Type /Font
>>
endobj
10 0 obj
<<
/Annots [16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R
26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R]
/Contents [35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R]
/CropBox [0 0 584.617 783.326]
/MediaBox [0 0 584.617 783.326]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/Separation /res_title_rule [/ICCBased 45 0 R]
46 0 R]
/CS1 [/Separation /res_doc_rule [/ICCBased 45 0 R]
47 0 R]
/CS2 [/Separation /res_title_text [/ICCBased 45 0 R]
48 0 R]
/CS3 [/ICCBased 45 0 R]
/CS5 [/Separation /res_head_text [/ICCBased 45 0 R]
49 0 R]
/CS6 [/Separation /res_doc_text [/ICCBased 45 0 R]
50 0 R]
>>
/ExtGState <<
/GS1 51 0 R
/GS6 52 0 R
/GS8 53 0 R
>>
/Font <<
/C0_0 54 0 R
/T1_0 55 0 R
/T1_1 56 0 R
/T1_10 57 0 R
/T1_11 58 0 R
/T1_12 59 0 R
/T1_2 60 0 R
/T1_3 61 0 R
/T1_4 62 0 R
/T1_5 63 0 R
/T1_6 64 0 R
/T1_7 65 0 R
/T1_8 66 0 R
/T1_9 67 0 R
/F15 68 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageI /ImageB]
/XObject <<
/Im0 69 0 R
>>
>>
/Rotate 0
/Type /Page
>>
endobj
11 0 obj
<<
/Annots [70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R
80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R
90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R
100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R
110 0 R 111 0 R 112 0 R 113 0 R 114 0 R]
/Contents [115 0 R 116 0 R 117 0 R]
/CropBox [0 0 584.617 783.326]
/MediaBox [0 0 584.617 783.326]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS6 [/Separation /res_head_text [/ICCBased 45 0 R]
49 0 R]
/Cs10 [/Separation /res_title_text [/ICCBased 45 0 R]
48 0 R]
/Cs13 [/Separation /res_doc_text [/ICCBased 45 0 R]
50 0 R]
/Cs6 [/ICCBased 45 0 R]
/Cs8 [/Separation /res_title_rule [/ICCBased 45 0 R]
46 0 R]
>>
/ExtGState <<
/GS2 51 0 R
>>
/Font <<
/F1 118 0 R
/F3 60 0 R
/F4 61 0 R
/F6 63 0 R
/F7 64 0 R
/F8 119 0 R
/F9 68 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Type /Page
>>
endobj
12 0 obj
<<
/Annots [120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R
130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R
140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R
150 0 R 151 0 R 152 0 R]
/Contents [153 0 R 154 0 R 155 0 R]
/CropBox [0 0 584.617 783.326]
/MediaBox [0 0 584.617 783.326]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS1 [/Separation /res_head_text [/ICCBased 45 0 R]
49 0 R]
/Cs14 [/Separation /res_head2_text [/ICCBased 156 0 R]
157 0 R]
/Cs6 [/ICCBased 45 0 R]
/Cs8 [/Separation /res_title_rule [/ICCBased 45 0 R]
46 0 R]
>>
/ExtGState <<
/GS2 51 0 R
>>
/Font <<
/F1 118 0 R
/F10 158 0 R
/F11 159 0 R
/F4 61 0 R
/F6 63 0 R
/F7 64 0 R
/F8 68 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Type /Page
>>
endobj
13 0 obj
<<
/Annots [160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R 169 0 R
170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R
180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R]
/Contents [187 0 R 188 0 R 189 0 R]
/CropBox [0 0 584.617 783.326]
/MediaBox [0 0 584.617 783.326]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS1 [/Separation /res_head_text [/ICCBased 45 0 R]
49 0 R]
/Cs6 [/ICCBased 45 0 R]
/Cs8 [/Separation /res_title_rule [/ICCBased 45 0 R]
46 0 R]
>>
/ExtGState <<
/GS2 51 0 R
>>
/Font <<
/F1 118 0 R
/F3 60 0 R
/F4 61 0 R
/F6 63 0 R
/F7 64 0 R
/F8 68 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Type /Page
>>
endobj
14 0 obj
<<
/Annots [190 0 R 191 0 R 192 0 R 193 0 R]
/Contents [194 0 R 195 0 R 196 0 R]
/CropBox [0 0 584.617 783.326]
/MediaBox [0 0 584.617 783.326]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS1 [/Separation /res_head_text [/ICCBased 45 0 R]
49 0 R]
/Cs10 [/Separation /res_title_text [/ICCBased 45 0 R]
48 0 R]
/Cs6 [/ICCBased 45 0 R]
/Cs8 [/Separation /res_title_rule [/ICCBased 45 0 R]
46 0 R]
>>
/ExtGState <<
/GS2 51 0 R
>>
/Font <<
/F1 118 0 R
/F2 158 0 R
/F3 60 0 R
/F4 61 0 R
/F5 62 0 R
/F6 63 0 R
/F7 64 0 R
/F8 68 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Type /Page
>>
endobj
15 0 obj
<<
/Contents [197 0 R 198 0 R 199 0 R]
/CropBox [0 0 584.617 783.326]
/MediaBox [0 0 584.617 783.326]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS1 [/Separation /res_head_text [/ICCBased 45 0 R]
49 0 R]
/Cs6 [/ICCBased 45 0 R]
/Cs8 [/Separation /res_title_rule [/ICCBased 45 0 R]
46 0 R]
>>
/ExtGState <<
/GS2 51 0 R
>>
/Font <<
/F1 118 0 R
/F3 60 0 R
/F4 61 0 R
/F5 62 0 R
/F6 63 0 R
/F7 64 0 R
/F8 68 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Type /Page
/Annots [200 0 R]
>>
endobj
16 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [94.507 600.491 162.142 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
17 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [162.142 600.491 164.126 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
18 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [162.142 600.491 164.126 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
19 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [174.671 600.491 176.145 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
20 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [163.956 600.491 176.145 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
21 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [166.167 600.491 176.145 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
22 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [168.435 600.491 176.145 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
23 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [170.646 600.491 176.145 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
24 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [172.913 600.491 176.145 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
25 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6176-2947)
>>
/Border [0 0 0]
/Rect [176.145 600.491 177.165 612.453]
/Subtype /Link
/Type /Annot
>>
endobj
26 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [151.597 154.658 155.225 163.616]
/Subtype /Link
/Type /Annot
>>
endobj
27 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [157.209 154.658 160.894 163.616]
/Subtype /Link
/Type /Annot
>>
endobj
28 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [453.77 204.775 457.512 213.732]
/Subtype /Link
/Type /Annot
>>
endobj
29 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [388.743 144.964 392.372 153.921]
/Subtype /Link
/Type /Annot
>>
endobj
30 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [394.299 144.964 398.041 153.921]
/Subtype /Link
/Type /Annot
>>
endobj
31 0 obj
<<
/Border [0 0 0]
/Dest
/Rect [430.242 97.172 433.984 106.129]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/A <<
/S /URI
/URI (mailto:mueller.astrid@mh-hannover.de)
>>
/Border [0 0 0]
/Rect [98.872 57.77 195.704 64.743]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1017/S1092852918001323)
>>
/Border [0 0 0]
/Rect [81.241 720.794 184.365 728.787]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [7.7999997 14.264648 133.62 22.189453]
/Border [0 0 0]
/A 201 0 R
>>
endobj
35 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
36 0 obj
<<
/Filter /FlateDecode
/Length 1014
>>
stream
HVnF+s<Ǫ妈H%@ $b 6)%qߗȢg8"%1)P/g=XAױhf/p:~z:X,J)c)N,N"BX[NbLgpMFϰM#RYHKEUqSx\uB!]#
+>_%0CkA4{f]ٟyyE'u!zoMh;ԜoߓsQ>ͪz|1Ia%ˢe^Owmf6 /?E0P]u"K=!*?˼\{d[0,5%(\4Ǫކ6tIQ.ֻ D`oqXo 3ᙠmVI82
"f[ORlIdrmXqM3- `HWjm>,PJ4fm}Wy=nh|[a{;30ۂ