Evaluation of Vitamin D in the serum of in-hospital patients with psychosis. Retrospective study.

Introduction The reduction of vitamin D (VitD) has often been associated with pathological cognitive processes and in general with various mental illnesses2,3. More frequent reports of reduced concentrations of VitD concern patients with schizophrenia, however it has not been clarified whether this concerns the pathology itself of the disorder or if nutritional factors are involved1. Objectives The measurement of VitD in the serum of hospitalized patients with mental illness (schizophrenia) compared to the levels of people without mental illness. Methods The serum levels of VitD were measured in the serum of 45 psychiatric patients of psychiatric hospital “Dromokaiteion” (22 men and 23 women) mean age 59 ±14 years. The control group consisted of 49 healthy subjects (24 men and 25 women) with a mean age of 57 ±14 years (Table 1). Serum VitD levels were measured on the Architect ci4100 immunobiochemical analyzer, Abbott Laboratories Ltd, by the chemiluminescent microparticle immune assay (CMIA) method and according to the manufacturer’s instructions. The statistical analysis of the data was done with the software program SPSS V.25. Results Mean values of Vit D (ng/ml) were 15.8±10.7 and 15.3±12.5 in male and female patients, respectively. For the control group the mean values were 22.4±7.9 in men and 26.4±13.9 in women. Vit D values in the psychiatric patients of both groups compared to the control group were statistically significantly different (men p=0.021 and women p=0.006). (Table2, 3). Image: Image 2: Image 3: Conclusions The findings of the study are consistent with those of similar studies confirming low concentrations of VitD in the serum of patients with mental illness. This parameter should be taken into account as its measurement is not included in the routine laboratory control to date. Further future studies should correlate VitD deficiency with specific demographic and clinical characteristics. 1. Belvederi Murri M, Respino M, Masotti M, et al. Vitamin D and psychosis: mini meta-analysis. Schizophr Res. 2013;150(1):235-239. doi:10.1016/j.schres.2013.07.017 2. Kalueff A, Minasyan A, Keisala T, Kuuslahti M, Miettinen S, Tuohimaa P. The vitamin D neuroendocrine system as a target for novel neurotropic drugs. CNS Neurol Disord Drug Targets. (2006) 5:363–71. doi: 10.2174/187152706784111506 3. Oudshoorn C, Mattace-Raso FU, van der Velde N, Colin EM, van der Cammen TJ. Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord. (2008) 25:539–43. doi: 10.1159/000134382 Disclosure of Interest None Declared


Introduction:
The reduction of vitamin D (VitD) has often been associated with pathological cognitive processes and in general with various mental illnesses 2,3 .More frequent reports of reduced concentrations of VitD concern patients with schizophrenia, however it has not been clarified whether this concerns the pathology itself of the disorder or if nutritional factors are involved 1 .Objectives: The measurement of VitD in the serum of hospitalized patients with mental illness (schizophrenia) compared to the levels of people without mental illness.Methods: The serum levels of VitD were measured in the serum of 45 psychiatric patients of psychiatric hospital "Dromokaiteion" (22 men and 23 women) mean age 59 AE14 years.The control group consisted of 49 healthy subjects (24 men and 25 women) with a mean age of 57 AE14 years (Table 1).Serum VitD levels were measured on the Architect ci4100 immunobiochemical analyzer, Abbott Laboratories Ltd, by the chemiluminescent microparticle immune assay (CMIA) method and according to the manufacturer's instructions.The statistical analysis of the data was done with the software program SPSS V.25.
Results: Mean values of Vit D (ng/ml) were 15.8AE10.7 and 15.3AE12.5 in male and female patients, respectively.For the control group the mean values were 22.4AE7.9 in men and 26.4AE13.9 in women.Vit D values in the psychiatric patients of both groups compared to the control group were statistically significantly different (men p=0.021 and women p=0.006).(Table2, 3).Introduction: Eye Movement Desensitization and Reprocessing (EMDR) is a powerful psychotherapy approach developed by Francine Shapiro in 1987 when she realized that rhythmic eye movements reduce disturbing thoughts.The effectiveness of the therapy has been proven by many studies after its discovery.EMDR, which was initially used only in the treatment of Post Traumatic Stress Disorder, has become a treatment option used in the treatment of psychiatric disorders of more than 2 million people today.EMDR, which is used today, contains elements from many therapy schools andconsists of a phased protocol (Shapiro, 2018).Increasing evidence acknowledging the relationship between trauma and psychosis indicates that EMDR can be a vital addition to the treatment of psychosis (Sin & Spain, 2017;Valiente-Gomez et al., 2017).However, the effect of EMDR on psychosis has not yet been sufficiently clarified.There is alsoIt has not yet been clarified whether the curative effect on the psychotic symptoms or on the anxiety symptoms.For this reason, in our study, the effect of EMDR on these symptoms will be investigated by comparing the case and control groups.
Objectives: This study aims to evaluate the effect of EMDR therapy on post-traumatic stress symptoms, schizophrenia symptom severity and anxiety level in psychotic patients with at least one traumatic event.
Methods: This study is a randomized controlled, prospective follow-up study aiming to evaluate the effect of EMDR therapy on post-traumatic stress symptoms, schizophrenia symptom severity and anxiety level in psychotic patients with at least one traumatic event.Written informed consent to participate in the intervention study will be requested from all patients who meet the inclusion criteria.
Consent participants receive pre-treatment (T0) measurements.After T0, participants will be randomized to EMDR or waiting list Participants will be randomly assigned to 26 people in each group.These groups will be made by the independent randomization bureau of the Parnassia Institute of Psychiatry using the scientific randomization program on the Internet (www.randomizer.org).Results: The effects of EMDR therapy on posttraumatic stress symptoms, schizophrenia symptom severity and anxiety level in psychotic patients were obtained from pretest and posttest measurements.Conclusions: More studies are needed on the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy.

EPV0937
Hyperammonemic Encephalopathy: valproic acidinduced adverse reaction E. Gómez*, L. Gallardo, R. Fernández, E. Talaya, L. Al Chaal and E. Rybak Introduction: Hyperammonemic encephalopathy is an unusual but fatal consequence of patients being treated with valproic acid (VPA).The most relevant clinical features in cases of valproic acidinduced hyperammonemia include confusion, lethargy, vomiting, and increased seizure frequency and may progress to stupor, coma, and lead to death in isolated cases.The causes are not fully elucidated, but studies suggest alterations in liver and kidney function with abnormalities in the urea cycle causing increased ammonium levels.Objectives: Clinical review and treatment approach for VPAinduced hyperammonemia encephalopathy.Methods: Clinical case and literature review.Results: A 23 -years -old male, admitted to the psychiatric unit for a psychotic episode in the context of drug use and associated affective symptoms.Treatment with antipsychotic (Risperidone 6mg per day) and mood stabilizer (valproic acid up to 1000/mg per day) was prescribed.After ten days of treatment, the patient started with low level of awareness and abnormal behaviour.Neurological examination showed marked somnolence, dysarthric language, unstable gait and behavioral alterations.In the physical examination the constants are stable with discrete tachycardia.Laboratory tests revealed hyperammonemia (609μg/dL), with normal liver function and serum concentration of total valproic acid was therapeutic (69mg/L).Brain computed tomography (CT) revealed no significant anomalies.Doctors initiated treatment with daily cleansing enema and VPA was suspended immediatly.After forty-eight hours the patient's mental status gradually improved back to baseline and the ammonium levels were normalized in medical tests.
The findings of the study are consistent with those of similar studies confirming low concentrations of VitD in the serum of patients with mental illness.This parameter should be taken into account as its measurement is not included in the routine laboratory control to date.Further future studies should correlate VitD deficiency with specific demographic and clinical characteristics.1. Belvederi Murri M, Respino M, Masotti M, et al.Vitamin D and psychosis: mini meta-analysis.Schizophr Res.2013;150(1):235-239. doi:10.1016/j.schres.2013.07.017 2. Kalueff A, Minasyan A, Keisala T, Kuuslahti M, Miettinen S, Tuohimaa P. The vitamin D neuroendocrine system as a target for novel neurotropic drugs.CNS Neurol Disord Drug Targets.(2006) 5:363-71.doi: 10.2174/187152706784111506 3. Oudshoorn C, Mattace-Raso FU, van der Velde N, Colin EM, van der Cammen TJ.Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer's disease.Dement Geriatr Cogn Disord.(2008) 25:539-43.doi: 10.1159/000134382 Disclosure of Interest: None Declared EPV0936 EFFECT OF EMDR THERAPY ON POST-TRAUMATIC STRESS SYMPTOMS, SYMPTOM SEVERITY AND ANXIETY LEVEL IN PSYCHOTIC PATIENTS WITH AT LEAST ONE TRAUMATIC EVENTS E. Yıldız 1 *, Z. Z. Yıldız 2 and M. Karadağ 2