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Self-organizing materials built with DNA

Published online by Cambridge University Press:  08 December 2017

Friedrich C. Simmel  and
Rebecca Schulman
Friedrich C. Simmel
Affiliation:
Technical University Munich, Germany; simmel@tum.de
Rebecca Schulman
Affiliation:
Johns Hopkins University, USA; rschulman@jhu.edu
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Abstract

Biological systems illustrate how complex and dynamic physical and chemical interactions between many different components can produce organized structures across length scales, ranging from angstroms to hundreds of meters, and precise temporal control over diverse material dynamics. While mechanisms for pattern formation such as reaction-diffusion processes, message passing, or rule-based assembly have been studied extensively using mathematical models, it can be difficult to create synthetic materials that implement these mechanisms. Here, we describe how DNA nanotechnology techniques make it possible to systematically build systems capable of complex self-organization or pattern formation across scales. DNA-programmed short-range interactions can be used to build aperiodic crystals and assemblies with long-range order, form patterns using reaction-diffusion and chemical message passing, and create self-organizing or stimulus-responsive amorphous materials, including gels or cell-sized compartments. Exploiting principles from self-organization using DNA-based interactions makes it possible to build materials with complex long-range order and intelligent spatiotemporal responses to a variety of stimuli using relatively simple bottom-up methods.

Type
Research Article
Information
MRS Bulletin , Volume 42 , Issue 12: DNA Nanotechnology: A foundation for Programmable Nanoscale Materials , December 2017 , pp. 913 - 919
Copyright
Copyright © Materials Research Society 2017 

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