PSYCHOTIC PATIENT AND AFFECTATION OF THE SEXUAL SPHERE. ABOUT A CLINICAL CASE

Introduction Clinical case description. A 44-year-old male, with paranoid schizophrenia, polydrug addict and IVDU since he was 14 years old. Live alone. He is brought by the Local Police for heteroaggressiveness when he was arrested for trespassing and resisting authority. He has presented 14 hospital admissions and therapeutic communities for detoxification since 2000. Objectives 1. To analyze the causes of abandonment of treatment Methods Complete medical history Blood test with hormone profile PRAEQ Questionnaire Absence of child psychopathology until the age of 6, at which time his parents separate and he becomes introverted, with solitary activities and distractions. On examination, the patient is restless. Psychotic contact. Delusional speech centered on ill-structured ideas of harm, persecution and grandiose, being difficult to explore due to lack of collaboration on the part of the patient, who only accepts treatment with aripiprazole 5 mg due to sexual dysfunction with the rest of the treatments. Results During his admission, he has evolved from a very unstructured delusional theme and social isolation, with lax and tangential speech and refusal to take any treatment except aripiprazole, towards a cooperative, trusting attitude, with attenuation of his delusional ideation, with appropriate, organized and releasable. Treatment with IM aripiprazole is agreed upon for discharge. Clinical judgement: Paranoid schizophrenia (F20.0) Conclusions With this case, we intend to remember that antipsychotics affect different spheres of the patient’s life that can hinder adherence to treatment, and that we often do not take into account. In this specific case, Abilify Maintena is useful because it does not cause sexual dysfunction, which facilitates treatment adherence and greater patient involvement, which gives us greater opportunities for social integration. Disclosure of Interest None Declared

Introduction: Schizophrenia is a chronic disease that deteriorates the functionality of patients, especially when raising a family and caring for children.We are interested in analyzing the characteristics of mothers and fathers diagnosed with schizophrenia and their degree of global activity when switching from oral treatments to injectable treatments.Objectives: 1 To evaluate the quality of life and functional level of mothers with schizophrenia treated with quarterly paliperidone palmitate.2. To compare the quality of life and functional level when switching from oral treatment to long-acting injectables.Methods: Participants were 3 mothers and 3 fathers, 33-40 years old, with a diagnosis of schizophrenia in monotherapy who changed treatment with monthly paliperidone palmitate to quarterly paliperidone palmitate LD IM (525 mg/every 12 weeks).Retrospective data collection.QLS quality of life scale.Results: Six patients were included, caregivers of 1 child (80%), 2 children (20%) who met the inclusion criteria and completed the questionnaires.After its application and correction by means of non-parametric tests (N<30).During oral treatment, scores are observed in the QLS questionnaire of: intrapsychic functions mean 34.2, interpersonal relationships mean 19, instrumental role mean 8, daily activities mean 8.After 12 months of treatment with intramuscular paliperidone palmitate (injectable every 12 weeks ) scores were obtained: intrapsychic functions mean 36, interpersonal relationships mean 23, instrumental role mean 15, daily activities mean 11.A better functioning of the patients was observed in the instrumental categories and daily activities.As well as the patients referred better adherence to treatment.Conclusions: In our experience, injectable long-acting Paliperidone Palmitate every 12 weeks is associated with the perception of a better quality of life in parents with schizophrenia and increases administration facilities as well as planning in their daily lives.

Introduction: Clinical case description.
A 44-year-old male, with paranoid schizophrenia, polydrug addict and IVDU since he was 14 years old.Live alone.He is brought by the Local Police for heteroaggressiveness when he was arrested for trespassing and resisting authority.He has presented 14 hospital admissions and therapeutic communities for detoxification since 2000.
Objectives: 1.To analyze the causes of abandonment of treatment Methods: 1. Complete medical history 2. Blood test with hormone profile 3. PRAEQ Questionnaire Absence of child psychopathology until the age of 6, at which time his parents separate and he becomes introverted, with solitary activities and distractions.On examination, the patient is restless.Psychotic contact.Delusional speech centered on ill-structured ideas of harm, persecution and grandiose, being difficult to explore due to lack of collaboration on the part of the patient, who only accepts treatment with aripiprazole 5 mg due to sexual dysfunction with the rest of the treatments.Results: During his admission, he has evolved from a very unstructured delusional theme and social isolation, with lax and tangential speech and refusal to take any treatment except aripiprazole, towards a cooperative, trusting attitude, with attenuation of his

EPV1022
Contribution of neurological soft signs' studies to the understanding of the pathophysiology of schizophrenia Introduction: Disruption of cerebral thermal homeostasis accompanies various CNS diseases.Presumably, (neuro)inflammation and the changes of temperature heterogeneity of the cerebral cortex may be interrelated links in the pathogenesis of schizophrenia.
Objectives: to study the association between the brain thermal balance indicators, inflammatory markers and clinical features of the disease in patients with schizophrenia during therapy.Methods: 37 patients aged 16 to 46 years with schizophrenia (F20, ICD-10) were examined.Clinical examination included psychometric assessment using PANSS, HDRS, and YMRS scales.Cortical temperature was determined by microwave radiometry.Temperature heterogeneity was assessed by calculating the Pearson correlation coefficient between temperature indicators in 9 symmetrical areas of the cerebral cortex.The activity of the proteolytic system of inflammation (ratio of leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI) activity) and the level of autoantibodies to S100B and MBP antigens were determined in patients' blood.
Results: Low temperature heterogeneity is related to an increase in the activity of the proteolytic system of inflammation and a good response to therapy in most patients.High temperature heterogeneity is associated with insufficient activity of the proteolytic system of inflammation and the development of autoimmune reactions, which is accompanied by a more severe course of the pathological process and, in most cases, treatment resistance.

Conclusions:
The association between the features of the thermal balance of the brain and inflammatory markers confirms the hypothesis of their role in the pathogenesis of schizophrenia.
Temperature heterogeneity of the brain can serve as a criterion for predicting of therapeutic response in patients with schizophrenia.
Disclosure of Interest: None Declared

Table 1 .
Treatment discontinuation, hospital admissions and suicide attempts [N(%)] With this case, we intend to remember that antipsychotics affect different spheres of the patient's life that can hinder adherence to treatment, and that we often do not take into account.In this specific case, Abilify Maintena is useful because it does not cause sexual dysfunction, which facilitates treatment adherence and greater patient involvement, which gives us greater opportunities for social integration.