Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-19T22:16:26.083Z Has data issue: false hasContentIssue false
  • English
  • Français

J'accuse! depression as a likely culprit in cases of AD

Published online by Cambridge University Press:  27 July 2016

David C. Steffens
David C. Steffens*
Affiliation:
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
*
Email: steffens@uchc.edu
Get access Rights & Permissions [Opens in a new window]

Extract

Clinicians have long appreciated the links between depression, cognitive impairment, and development of Alzheimer's disease (AD) and other dementias. More recently, investigators in the fields of epidemiology, genetics, neuroimaging, and neuropathology have sought to quantify the risk and to understand the underlying neurobiology of the relationship between depression and AD.

Type
Commentary
Information
International Psychogeriatrics , Volume 28 , Issue 9 , September 2016 , pp. 1407 - 1408
Copyright
Copyright © International Psychogeriatric Association 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barnes, D. E. and Yaffe, K. (2011). The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurology, 10, 819–828.CrossRefGoogle ScholarPubMed
Burke, S. L., Maramaldi, P., Cadet, T. and Kukull, W. (2016). Associations between depression, sleep disturbance, and apolipoprotein E in the development of Alzheimer's disease. International Psychogeriatrics. doi:10.1017/S1041610216000405.CrossRefGoogle Scholar
Modrego, P. J. and Ferrández, J. (2004). Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Archives of Neurology, 61, 1290–1293.CrossRefGoogle ScholarPubMed
Jorm, A. F. (2001). History of depression as a risk factor for dementia: an updated review. Australia and New Zealand Journal of Psychiatry, 35, 776–781.CrossRefGoogle ScholarPubMed
Sheline, Y. I., Sanghavi, M., Mintun, M. A. and Gado, M. H. (1999). Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. Journal of Neuroscience, 19, 5034–5043.CrossRefGoogle Scholar
Steffens, D. C., Plassman, B. L., Helms, M. J., Welsh-Bohmer, K. A., Saunders, A. M. and Breitner, J. C. (1997). A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. Biological Psychiatry, 41, 851–856.CrossRefGoogle ScholarPubMed
Steffens, D. C., McQuoid, D. R., Payne, M. E. and Potter, G. G. (2011). Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study. American Journal of Geriatric Psychiatry, 19, 4–12.CrossRefGoogle ScholarPubMed
Steffens, D. C., McQuoid, D. R. and Potter, G. G. (2014). Amnestic mild cognitive impairment and incident dementia and Alzheimer's disease in geriatric depression. International Psychogeriatrics, 26, 2029–2036.CrossRefGoogle ScholarPubMed