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Assessment of prestin level changes as an inner-ear biomarker in patients with idiopathic sudden sensorineural hearing loss

Published online by Cambridge University Press:  22 October 2021

F Saadat ,
M M Jalali Open the ORCID record for M M Jalali [Opens in a new window]  and
M Akbari
F Saadat
Affiliation:
Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
M M Jalali*
Affiliation:
Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
M Akbari
Affiliation:
Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
*
Author for correspondence: Prof Mir Mohammad Jalali, Otorhinolaryngology Research Center, Amiralmomenin Hospital, Rasht 4193875197, Iran E-mail: mmjalali@gmail.com
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Abstract

Objective

To assess the correlation of serum prestin level and audiological findings in adults with idiopathic sudden sensorineural hearing loss.

Methods

Audiometry and serum prestin measurements were performed at study entry (T0), at day 14 (end of treatment, T1) and at day 30 (T2).

Results

A total of 25 idiopathic sudden sensorineural hearing loss patients and 25 healthy adults were included. The geometric mean prestin level in the case and control groups at T0 was 227.7 pg/ml and 130.5 pg/ml, respectively. The geometric mean prestin level in the case group demonstrated a downward trend at T1 and T2 (214.0 pg/ml and 180.1 pg/ml, respectively; p < 0.001). Of 17 patients with high baseline prestin levels (over 150 pg/ml), prestin levels tended to decrease in 11 patients, and 5 of them (45.5 per cent) showed good recovery.

Conclusion

The prestin concentrations increased in two-thirds of patients with idiopathic sudden sensorineural hearing loss. Future work is recommended to determine the location of injury.

Keywords

Sensorineural Hearing LossAudiometryPure-TonePrestinBiomarkers
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 11 , November 2022 , pp. 1039 - 1043
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Prof M M Jalali takes responsibility for the integrity of the content of the paper

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