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Single-crystal structure analysis of designer drugs circulating in the Japanese drug market by the synchrotron radiation X-ray diffraction

Published online by Cambridge University Press:  20 June 2017

Takashi Hashimoto ,
Ruri Hanajiri ,
Nobuhiro Yasuda ,
Yuki Nakamura ,
Nobuhiro Mizuno ,
Sadao Honda ,
Shinjiro Hayakawa ,
Yoshinori Nishiwaki  and
Shigeru Kimura
Takashi Hashimoto*
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan
Ruri Hanajiri
Affiliation:
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Nobuhiro Yasuda
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Yuki Nakamura
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Nobuhiro Mizuno
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Sadao Honda
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Shinjiro Hayakawa
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan Faculty of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima-shi, Hiroshima 739-8527, Japan
Yoshinori Nishiwaki
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan Faculty of Education, Kochi University, 2-5-1 Akebono-cho, Kochi 780-8520, Japan
Shigeru Kimura
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
*
a)Author to whom correspondence should be addressed. Electronic mail: thashimoto@spring8.or.jp
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Abstract

Over the past 20 years, many designer drugs derived from controlled substances have been widely distributed as easily available psychoactive substances and have become a serious problem in Japan. In order to determine the absolute structures of four new designer drugs derived from medicines (methylphenidate and phenmetrazine) X-ray single-crystal structure analyses were performed using the BL26B1 beamline of synchrotron radiation facility SPring-8. The results show that the molecular configuration of these designer drugs (having two asymmetric carbons), which were distributed in the illegal drug market had threo-forms as found for methylphenidate and phenmetrazine.

Keywords

synchrotron XRDdesigner drugs
Type
Technical Articles
Information
Powder Diffraction , Volume 32 , Issue 2 , June 2017 , pp. 112 - 117
Copyright
Copyright © International Centre for Diffraction Data 2017 

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References

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