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Immunodepression in hamsters experimentally infected with Opisthorchis viverrini

Published online by Cambridge University Press:  05 June 2009

S. Wongratanacheewin ,
W. Rattanasiriwilai ,
R. Priwan  and
S. Sirisinha
S. Wongratanacheewin
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
W. Rattanasiriwilai
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
R. Priwan
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
S. Sirisinha*
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
*
*For all correspondence
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Abstract

Hamsters experimentally infected with Opisthorchis viverrini had significant depression of the antibody response to sheep red blood cells. The depression was more severe with prolonged infections. Lymphoproliferative response to phytohaemagglutinin stimulation was also depressed when compared with uninfected controls. The immunodepression in these animals was abolished by anthelmintic treatment, suggesting that the immunodepressive effect is reversible and is associated with active infection.

Keywords

Opisthorchis viverrinihamsterimmunodepression
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 151 - 156
Copyright
Copyright © Cambridge University Press 1987

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