Hostname: page-component-76fb5796d-9pm4c Total loading time: 0 Render date: 2024-04-25T06:59:19.889Z Has data issue: false hasContentIssue false
  • English
  • Français

The release of histamine from nasal polyp tissue and peripheral blood when challenged with antihuman IgE, house dust mite extract and mixed grass pollen extract and compared with positive skin tests

Published online by Cambridge University Press:  29 June 2007

A. B. Drake-Lee  and
P. Mcloughlan
A. B. Drake-Lee*
Affiliation:
Consultant ENT Surgeon, Queen Elizabeth Hospital, Birmingham B15 2TH.
P. Mcloughlan
Affiliation:
Dept of Immunology, Addenbrookes Hospital, Cambridge.
*
Queen Elizabeth Hospital, Birmingham B15 2TH.
Get access Rights & Permissions [Opens in a new window]

Abstract

Nasal polyps are a condition of uncertain aetiology but are associated with diseases of the lower respiratory tract, in particular, asthma and cystic fibrosis. Asthma may be mediated by mastcell reactions and the commonest allergen to degranulate mast cells is house dust mite. Mast cells have been shown to be degranulated in nasal polyps. This study looks at thirty-six patients who had nasal polypectomy and of whom fourteen were asthmatic to see if histamine wasreleased from polyp tissue and peripheral blood when they were challenged with antihuman IgE and extracts of house dust mite and mixed grass pollens. These results were compared with skin tests to these allergens. A release of above 15 per cent of the total histamine was considered positive. Eight patients released histamine from polyp tissue but only three patients released histamine with both anti IgE and allergen extracts. The release from blood compared well with positive skin tests (p >0.05 corrected chi square). Although allergy may cause mast cell degranulation in polyp tissue, this study suggests that it is unlikely to be a common cause of nasal polyps.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 10 , October 1988 , pp. 886 - 889
Copyright
Copyright © JLO (1984) Limited 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baenkler, H. W., Schaubschläger, W. and Behnsen, H. (1983) Antigen induced histamine release from mucosa in nasal polyposis. Clinical Otolaryngology,8: 227–230.CrossRefGoogle ScholarPubMed
Busuttil, A., More, I. A. R. and McGeveney, D. (1976) Ultrastructure of the stroma of nasal polyps. Archives of Otolaryngology, 102: 589–595.CrossRefGoogle ScholarPubMed
Cauna, N., Hindover, K. H., Manzethi, G. W. and Swanson, E. W. (1972) Fine structure of nasal polyps. Annals of Otolaryngology 81: 41–58.Google ScholarPubMed
Drake-Lee, A. B. and McLaughlan, P. (1982)Clinical symptoms, free histamine and IgE in patients with nasal polyps. International Archives of Allergy and Applied Immunology. 69: 268–271.CrossRefGoogle Scholar
Drake-Lee, A. B., McLaughlan, P., Barker, T. (1982) Histamine, asthma and nasal polyps. Lancet 2: 213.CrossRefGoogle ScholarPubMed
Drake-Lee, A. B., Barker, T. H. W. and Thurley, K. (1984a) Nasal Polyps II. Fine structure of mast cells. Journal of Laryngology and Otology 98: 285–292.CrossRefGoogle Scholar
Drake-Lee, A. B., Lowe, D., Swanston, A. and Grace, A. (1984b) Clinical profile and recurrence of nasal polyps. Journal of Laryngology and Otology 98: 783–793.CrossRefGoogle ScholarPubMed
Evans, D. P., Lewis, J. A. and Thompson, D. S. (1973) An automated fluometric assay for the rapid determination of histamine in biological fluids. Life Science 12: 327–330.CrossRefGoogle Scholar
Kaliner, M., Wasserman, S. I. and Austen, K. F. (1973) Immunologic release of chemical mediators from human nasal polyps. New England Journal of Medicine 289: 277–281.CrossRefGoogle ScholarPubMed
McLaughlan, P. and Coombs, R. R. A. (1983)Latent anaphylactic sensitivity in infants to cows milk proteins.(Histamine release from blood basophils). Clinical Allergy 13: 1–9.CrossRefGoogle ScholarPubMed
Norman, P. S., Lichtenstein, L. M. and Ishizake, K. (1973) Diagnostic tests in ragweed hay fever. (A comparison of direct skin tests, IgE antibody measurements and basophil histamine release). Journal of Allergy and Clinical Immunology 52: 210–224.CrossRefGoogle ScholarPubMed
Pearce, F. L. (1986) On the heterogeneity of mast cells. Pharmacology. 32: 61–71.CrossRefGoogle ScholarPubMed
Shaw, R., Drake-Lee, A. B., Fitzharris, P., Cromwell, O. and Kay, A. (1985) Leukotrines in nasal hypersensitivity and polyposis. Thorax 40: 215–216.Google Scholar