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Schistosoma mansoni: stage-dependent damage after in vivo treatment with praziquantel

Published online by Cambridge University Press:  06 April 2009

M. K. Shaw
M. K. Shaw
Affiliation:
Department of Zoology, University College, Cardiff, Wales, UK
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Summary

The in vivo effects of a single, subcurative dose (200 mg/kg body wt of mouse) of praziquantel on the structure of the tegument and subtegumental tissues of juvenile (21-, 26- and 30-day-old) and adult Schistosoma mansoni are described. In juvenile worms praziquantel caused only moderate damage to both the tegument and subtegumental tissues although the degree of drug-induced damage was related to both the sex of the worms and to the developmental status of each individual worm. In general, male worms exhibited more extensive and longer lasting surface damage than females. However, the level and extent of the changes increased as the worms became more developmentally advanced with adult worms showing extensive damage to the tegument and vacuolization and disruption of the subtegumental tissues. The possible correlation between the stage-dependent changes in susceptibility to praziquantel and age-related changes, particularly in the phospholipid composition of the outer tegumental membrane is discussed.

Keywords

Schistosoma mansonipraziquanteltegumentstage-specific effects
Type
Research Article
Information
Parasitology , Volume 100 , Issue 1 , February 1990 , pp. 65 - 72
Copyright
Copyright © Cambridge University Press 1990

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