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A whole genome scan to detect quantitative trait loci for gestation length and sow maternal ability related traits in a White Duroc × Erhualian F2 resource population

Published online by Cambridge University Press:  17 February 2010

C. Y. Chen ,
Y. M. Guo ,
Z. Y. Zhang ,
J. Ren  and
L. S. Huang
C. Y. Chen
Affiliation:
Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045 Nanchang, China
Y. M. Guo
Affiliation:
Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045 Nanchang, China
Z. Y. Zhang
Affiliation:
Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045 Nanchang, China
J. Ren
Affiliation:
Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045 Nanchang, China
L. S. Huang*
Affiliation:
Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045 Nanchang, China
*
†E-mail: Lushenghuang@hotmail.com
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Abstract

Gestation length and maternal ability are important to improve the sow reproduction efficiency and their offspring survival. To map quantitative trait loci (QTL) for gestation length and maternal ability related traits including piglet survival rate and average body weight of piglets at weaning, more than 200 F2 sows from a White Duroc × Erhualian resource population were phenotyped. A genome-wide scan was performed with 194 microsatellite markers covering the whole pig genome. QTL analysis was carried out using a composite regression interval mapping method via QTL express. The results showed that total number of born piglets was significantly correlated with gestation length (r = −0.13, P < 0.05). Three QTL were detected on pig chromosome (SSC)2, 8 and 12 for gestation length. The QTL on SSC2 achieved the 5% genome-wide significant level and the QTL on SSC8 was consistent with previous reports. Four suggestive QTL were identified for maternal ability related traits including 1 QTL for survival rate of piglets at weaning on SSC8, 3 QTL for average body weight of piglet at weaning on SSC3, 11 and 13.

Keywords

gestation lengthmaternal ability related traitsQTLresource population
Type
Full Paper
Information
animal , Volume 4 , Issue 6 , June 2010 , pp. 861 - 866
Copyright
Copyright © The Animal Consortium 2010

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References

Casellas, J, Varona, L, Muñoz, G, Ramírez, O, Barragán, C, Tomás, A, Martínez-Giner, M, Óvilo, C, Sánchez, A, Noguera, JL, Rodríguez, MC 2008. Empirical Bayes factor analyses of quantitative trait loci for gestation length in Iberian × Meishan F2 sows. Animal 2, 177–183.CrossRefGoogle ScholarPubMed
Cassady, JP, Young, LD, Leymaster, KA 2002. Heterosis and recombination effects on pig reproductive traits. Journal of Animal Science 80, 2303–2315.CrossRefGoogle ScholarPubMed
Chen, C, Gilbert, CL, Yang, G, Guo, Y, Segonds-Pichon, A, Ma, J, Brenig, B, Sargent, CA, Affara, NA, Huang, L 2008. Maternal infanticide in sows: incidence and behavioral comparisons between savaging and non-savaging sows at parturition. Applied Animal Behaviour Scence 109, 238–248.CrossRefGoogle Scholar
Chen, C, Guo, Y, Yang, G, Yang, Z, Zhang, Z, Yang, B, Yan, X, Perez-Enciso, M, Ma, J, Duan, Y, Brenig, B, Huang, L 2009. A genome wide detection of quantitative trait loci on pig maternal infanticide behavior in a large scale White Duroc × Erhualian resource population. Behavior Genetics 39, 213–219.CrossRefGoogle Scholar
Churchill, GA, Doerge, RW 1994. Empirical threshold values for quantitative trait mapping. Genetics 138, 963–971.CrossRefGoogle ScholarPubMed
de Koning, DJ, Harlizius, B, Rattink, AP, Groenen, MA, Brascamp, EW, van Arendonk, JA 2001. Detection and characterization of quantitative trait loci for meat quality traits in pigs. Journal of Animal Science 79, 2812–2819.CrossRefGoogle ScholarPubMed
Ding, N, Guo, Y, Knorr, C, Ma, J, Mao, H, Lan, L, Xiao, S, Ai, H, Haley, CS, Brenig, B, Huang, L 2009. Genome-wide QTL mapping for three traits related to teat number in a White Duroc × Erhualian pig resource population. BMC Genetics 10, 6.CrossRefGoogle Scholar
Dziuk, P 1991. Reproduction in the pig. In Reproduction in domestic animals (ed. PT Cupps), pp. 471–489. Academic Press, New York.Google Scholar
Gäde, S, Bennewitz, J, Kirchner, K, Looft, H, Knap, PW, Thaller, G, Kalm, E 2008. Genetic parameters for maternal behavior traits in sows. Livestock Science 114, 31–41.CrossRefGoogle Scholar
Green, P, Falls, K, Crook, S 1990. Documentation for CRIMAP, version 2.4. Washington University School of Medicine, St Louis, MO, USA.Google Scholar
Guo, YM, Mao, HR, Ren, J, Yan, XM, Duan, YY, Yang, GC, Ren, DR, Zhang, ZY, Yang, B, Ouyang, J, Brenig, B, Haley, CS, Huang, LS 2009. A linkage map of the porcine genome from a large scale White Duroc × Erhualian resource population and evaluation of factors affecting recombination rates. Animal Genetics 40, 47–52.CrossRefGoogle ScholarPubMed
Haley, CS, Knott, SA, Elsen, JM 1994. Mapping quantitative trait loci in crosses between out bred lines using least squares. Genetics 136, 1195–1207.CrossRefGoogle Scholar
Hanenberg, EHAT, Knol, EF, Merks, JWM 2001. Estimates of genetic parameters for reproduction traits at different parities in Dutch Landrace pigs. Livestock Production Science 69, 179–186.CrossRefGoogle Scholar
Holyoake, PK, Dial, GD, Trigg, T, King, VL 1995. Reducing pig mortality through supervision during the perinatal period. Journal of Animal Science 73, 3543–3551.CrossRefGoogle ScholarPubMed
Hu, Z, Dracheva, S, Jang, W, Maglott, D, Bastiaansen, J, Rothschild, MF, Reecy, JM 2005. A QTL resource and comparison tool for pigs: PigQTLDB. Mammalian Genome 16, 792–800.CrossRefGoogle ScholarPubMed
Jiang, Z, Robinson, JAB, Verrinder Gibbins, AM, Gibson, JP, Archibald, AL, Haley, CS 2002. Mapping of QTLs for prolificacy traits on SSC8 using a candidate gene approach. 7th world congress on genetic applied to livestock production, 19–23 August, Montpellier, France.Google Scholar
Johnson, RK, Nielsen, MK, Casey, DS 1999. Responses in ovulation rate, embryonal survival, and litter traits to 14 generations of selection to increase litter size. Journal of Animal Science 77, 541–557.CrossRefGoogle ScholarPubMed
Kennedy, BW, Moxley, JE 1978. Genetic and environmental factors influencing litter size, sex ratio, and gestation length in the pig. Animal Production 27, 35–42.Google Scholar
King, AH, Jiang, Z, Gibson, JP, Haley, CS, Archibald, AL 2003. Mapping quantitative trait loci affecting female reproductive traits on porcinechromosome 8. Biology of Reproduction 68, 2172–2179.CrossRefGoogle ScholarPubMed
Knol, EF, Leenhouwers, JI, Van der Lende, T 2002. Genetic aspects of piglet survival. Livestock Production Science 78, 47–55.CrossRefGoogle Scholar
Lee, PC, Majluf, P, Gordon, IJ 1991. Growth, weaning and maternal investment from a comparative perspective. Journal of Zoology 225, 99–114.CrossRefGoogle Scholar
Leenhouwers, JI, Van der Lende, T, Knol, EF 1999. Analysis of stillbirth in different lines of pig. Livestock Production Science 57, 243–253.CrossRefGoogle Scholar
Leigh, AO 1981. Factors affecting the gestation period of pigs in Nigeria. Tropical Animal Health and Production 13, 87–93.CrossRefGoogle ScholarPubMed
Li, K, Ren, J, Xing, Y, Zhang, Z, Ma, J, Guo, Y, Huang, L 2009. Quantitative trait loci for litter size and prenatal loss in a White Duroc × Chinese Erhualian resource population. Animal Genetics 40, 963–966.CrossRefGoogle Scholar
Nguyen, NH, McPhee, CP, Wade, CM 2006. Genetic variation and responses in reproductive performance of sows in lines selected for growth rate under restricted feeding. Animal Science 82, 7–12.CrossRefGoogle Scholar
Peripato, AC, De Brito, RA, Vaughn, TT, Pletscher, LS, Matioli, SR, Cheverud, JM 2002. Quantitative trait loci for maternal performance for offspring survival in mice. Genetics 162, 1341–1353.CrossRefGoogle ScholarPubMed
Rathje, TA, Rohrer, GA, Johnson, RK 1997. Evidence for quantitative trait loci affecting ovulation rate in pigs. Journal of Animal Science 75, 1486–1494.CrossRefGoogle ScholarPubMed
Rohrer, GA, Alexander, LJ, Hu, Z, Smith, TP, Keele, JW, Beattie, CW 1996. A comprehensive map of the porcine genome. Genome Research 6, 371–391.CrossRefGoogle ScholarPubMed
Sasaki, Y, Koketsu, Y 2007. Variability and repeatability in gestation length related to litter performance in female pigs on commercial farms. Theriogenology 68, 123–127.CrossRefGoogle ScholarPubMed
Seaton, G, Haley, CS, Knott, SA, Kearsey, M, Visscher, PM 2002. QTL express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics 18, 339–340.CrossRefGoogle ScholarPubMed
Sinclair, AG, Edwards, SA, Hoste, S, McCartney, A 1998. Evaluation of the influence of maternal and piglet breed differences on behavior and production of Meishan synthetic and European White breeds during lactation. Animal Science 66, 423–430.CrossRefGoogle Scholar
Tomas, A, Frigo, E, Casellas, J, Ramírez, O, Ovilo, C, Noguera, JL, Sánchez, A 2006. An association study between polymorphisms of the porcine bone morphogenetic protein receptor type1beta (BMPR1B) and reproductive performance of Iberian × Meishan F2 sows. Animal Genetics 37, 297–298.CrossRefGoogle ScholarPubMed
van der Steen, HA, de Groot, PN 1992. Direct and maternal breed effects on growth and milk intake of piglets: Meishan versus Dutch breeds. Livestock Production Science 30, 361–373.CrossRefGoogle Scholar
Visscher, PM, Thompson, R, Haley, CS 1996. Confidence intervals in QTL mapping by bootstrapping. Genetics 143, 1013–1020.CrossRefGoogle ScholarPubMed
Wilkie, PJ, Paszek, AA, Beattie, CW, Alexander, LJ, Wheeler, MB, Schook, LB 1999. A genomic scan of porcine reproductive traits reveals possible quantitative trait loci (QTLs) for number of corpora lutea. Mammalian Genome 10, 573–578.CrossRefGoogle ScholarPubMed
Yang, G, Ren, J, Li, S, Mao, H, Guo, Y, Zou, Z, Ren, D, Ma, J, Huang, L 2008. Genome-wide identification of QTL for age at puberty in gilts using a large intercross F2 population between White Duroc × Erhualian. Genetics Selection Evolution 40, 529–539.Google Scholar