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Optimal High-Throughput Screening
Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research


  • Date Published: April 2011
  • availability: In stock
  • format: Hardback
  • isbn: 9780521517713

£ 75.99

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About the Authors
  • This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

    • A concise, self-contained and cohesive book for designing, analyzing and interpreting RNAi HTS experiments
    • Suitable for biologists, statisticians and bioinformaticians
    • Elaborates newly developed analytic methods with a statistically sound basis
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    Product details

    • Date Published: April 2011
    • format: Hardback
    • isbn: 9780521517713
    • length: 232 pages
    • dimensions: 260 x 182 x 17 mm
    • weight: 0.61kg
    • contains: 47 b/w illus. 23 tables
    • availability: In stock
  • Table of Contents

    Part I. RNAi HTS and Data Analysis:
    1. Introduction to genome-scale RNAi research
    2. Experimental designs
    3. Data display and normalization
    4. Quality control in genome-scale RNAi screens
    5. Hit selection in genome-scale RNAi screens without replicates
    6. Hit selection in genome-scale RNAi screens with replicates
    Part II. Methodological Development for Analyzing RNAi HTS Screens:
    7. Statistical methods for group comparison
    8. Statistical methods for assessing the size of siRNA effects.

  • Author

    Xiaohua Douglas Zhang, Merck Research Laboratories, Pennsylvania
    Dr Xiaohua Douglas Zhang is an associate director at Merck Research Laboratories. He has worked on data analysis for genome-wide RNAi research and microarrays in drug discovery and development for various diseases for many years. He has continuously developed novel analytic methods and experimental designs for quality control and hit selection in genome-scale RNAi research. He and his colleagues have published many papers in various peer-reviewed journals, including Cell Host and Microbe, Nucleic Acids Research, Bioinformatics, Genetic Epidemiology, the Journal of Biological Chemistry, Pharmacogenomics, Genomics and the Journal of Biomolecular Screening, among many others.

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