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Chromatographic Processes
Modeling, Simulation, and Design


Part of Cambridge Series in Chemical Engineering

  • Date Published: April 2015
  • availability: Available
  • format: Hardback
  • isbn: 9781107082366

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About the Authors
  • Addressing all aspects of the design, modeling and simulation of chromatographic processes, this result-oriented primer provides a practical guide to all the necessary approaches, methodologies and tools. Beginning with key definitions and concepts, it builds up from the most simple to the most complex situations, including multicomponent systems, non-uniform velocity profiles, bed instability, particle size distributions, and the influence of complex environments on chromatographic process design. In addition to covering classical approaches, it introduces efficient tools for investigating chromatographic processes, such as the 'Russian-Lego' approach for linear systems, phenomenological models, and specific shortcuts for deriving the key properties of industrial processes. With an emphasis on real-world problems and applications, step-by step modeling design guidelines, and detailed exercises for self-assessment, this is a must-have guide for practitioners and researchers working in chemical, biochemical, food and pharmaceutical engineering.

    • Includes step-by-step modelling design guidelines to rationalise design and cut design time and cost
    • Addresses all aspects of modelling and simulation, within a consistent theoretical and notational framework
    • Demonstrates the connection between modelling and complex real-world interactions
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    Product details

    • Date Published: April 2015
    • format: Hardback
    • isbn: 9781107082366
    • length: 672 pages
    • dimensions: 254 x 182 x 34 mm
    • weight: 1.45kg
    • contains: 163 b/w illus.
    • availability: Available
  • Table of Contents

    1. An approach to modeling chromatographic processes
    2. Linear chromatography: the Russian Lego
    3. Non-linear chromatography: equilibrium theory
    4. Fluid-solid phase equilibria
    5. Mass transfer
    6. Hydrodynamics of chromatographic columns
    7. Simulating chromatographic columns
    8. Counter-current systems
    9. Presentation of chromatographic modes and their optimization
    10. Addressing a few industrial problems
    11. Conclusion.

  • Author

    Roger-Marc Nicoud, Ypso-Facto, Nancy, France
    Roger-Marc Nicoud is the founder and former CEO of Novasep, which has installed over 2000 chromatographic units worldwide, and pioneered the use of large-scale continuous chromatographic processes in the life science industry. He is President of École Nationale Supérieure des Industries Chimiques (ENSIC), and in 2014, founded Ypso-Facto (

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