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The Hemopoietic Colony-stimulating Factors
From Biology to Clinical Applications

  • Date Published: December 2006
  • availability: Available
  • format: Paperback
  • isbn: 9780521034814

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About the Authors
  • The colony-stimulating factors (CSFs) are the major regulators in the body of the production and activity of two types of white blood cells - granulocytes and macrophages. This book provides a detailed account of the discovery of the CSFs, their structure, molecular biology and cellular receptors, the biology of the CSFs in vivo and in vitro and their present and future clinical applications. Written by two of the pioneers in the discovery of CSFs, it is a clear and well-illustrated survey of the history, knowledge and future directions of this exciting field of investigation, and serves also as a guide to the more general areas of growth factor and cytokine research. It will prove an invaluable review for cell biologists interested in how growth factors act on the body, as well as for clinicians applying the fruits of modern biotechnology to improved patient care.

    • Written by two of the pioneers in the discovery of CSFs; Metcalf is a world-renowned scientist
    • Complete review of CSF's discovery, biology and clinical applications
    • Beautiful illustrations, specially prepared for this book
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    Reviews & endorsements

    'This is one of the most easily accessible books which ranges comprehensively from biochemistry and molecular genetics of the cytokines to their clinical uses in the treatment of disease.' G. J. Mufti and P. Towner, Journal of the Royal College of Physicians

    'Those who are involved in basic and applied research in this rapidly evolving field will find this book to be a most worthwhile addition to their library.' John M. Bennett, Leukemia Research

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    Product details

    • Date Published: December 2006
    • format: Paperback
    • isbn: 9780521034814
    • length: 356 pages
    • dimensions: 228 x 152 x 20 mm
    • weight: 0.537kg
    • contains: 72 b/w illus. 30 tables
    • availability: Available
  • Table of Contents

    Preface
    1. Historical introduction
    2. General introduction to hemopoiesis
    3. Key techniques in analyzing hemopoiesis
    4. Biochemistry of the colony-stimulating factors
    5. Biochemistry of the colony-stimulating factor receptors
    6. Molecular genetics of the colony-stimulating factors and their receptors
    7. Biological actions of the colony-stimulating factors in vitro
    8. The biology of colony-stimulating factor production, degradation and clearance
    9. Actions of the colony-stimulating factors in vivo
    10. Role of the colony-stimulating factors in basal hemopoiesis
    11. Actions of the colony-stimulating factors in resistance to infections
    12. Role of the colony-stimulating factors in other disease states
    13. The colony-stimulating factors and myeloid leukemia
    14. Clinical uses of the colony-stimulating factors
    15. Conclusions
    References
    Index.

  • Authors

    Donald Metcalf, Walter and Eliza Hall Institute of Medical Research, Victoria

    Nicos Anthony Nicola, Walter and Eliza Hall Institute of Medical Research, Victoria

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