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Homocysteine in Health and Disease

David Wilken, Bridget Wilken, Donald W. Jacobsen, Hieronim Jakubowski, Jay W. Heinecke, Andrew J. Gow, Fred Cobb, Jonathan S. Stamler, Jose M. Mato, Matias A. Avila, Fernado J. Corrales, Steven G. Clarke, Kelly Banfield, Sean T. Prigge, Peter K. Chiang, James D. Finkelstein, Rowena G. Matthews, Martha L. Ludwig, Robert J. Cook, Ruma V. Banerjee, Horatiu Olteanu, Tim Garrow, Warren D. Kruger, Brian Fowler, John T. Brosnan, Anne M. Molloy, Donald G. Weir, Karsten Rasmussen, Jan Möller, Nicholas Dudman, Jonathan Silberberg, Jan P. Kraus, Viktor Kozich, David S. Rosenblatt, Ralph Carmel, Jesse F. Gregory III, Margret Arnadottir, Björn Hultberg, Henk J. Blom, Stein Emil Vollset, Helga Refsum, Ottar Nygard, Per Ueland, Petra Verhoef, Meir Stampfer, Killian Robinson, J. David Spence, James F. Toole, Godfried Boers, Armando D'Angelo, Chiara Beltrametti, Katherine A. Hajjar, Steven R. Lentz, T. K. A. B. Eskes, John M. Scott, Robert Clarke, Johan B. Ubbink
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  • Date Published: December 2011
  • availability: Available
  • format: Paperback
  • isbn: 9781107402423

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  • High levels of homocysteine have been identified as a very important risk factor in cardiovascular disease. Homocysteine-related abnormalities are also thought to contribute to birth defects and dementia, and there are many common acquired diseases, drugs and genetic disorders which adversely affect the metabolism of homocysteine. In this 2001 book a multidisciplinary team of experts in the field give a clear analysis of the biochemistry, genetics, epidemiology, clinical settings, causes, impact and treatment of homocysteine disorders. This is an unusually comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine in health and disease.

    • Covers the basic science and clinical issues across the broad medical spectrum of this increasingly important area
    • Unusually comprehensive
    • Written by an international team of experts
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    Reviews & endorsements

    Review of the hardback: 'The field of homocysteine research has been crying out for a textbook like this, as it pulls together the disparate research areas of nutrition, biochemistry, cardiovascular medicine and inherited metabolic disease.' Doctors.net

    Review of the hardback: 'The editors have structured the book logically, and ensured that this enormous subject is covered comprehensively, yet concisely, with minimum overlap, and helpful cross-referencing. They have successfully bridged the interface between the relevant basic and applied sciences and produced a beautifully balanced overview of the role of homocysteine in health and disease. There is no publication like it in this speciality, where it is likely to become the standard reference.' Graeme J. Hankey, The Lancet

    Review of the hardback: 'This book provides an excellent up-to-date review of scientific and clinical grounding of homocysteine metabolism in health and disease, illustrated attractively with useful diagrams and figures. It is well-indexed, with an extensive bibliography. This book will be of interest and a good reference text for both basic scientists and clinicians.' Brain 2002

    Review of the hardback: 'This book is impressive in its scope and comes at a time when many have heard of homocysteine but few really understand the molecule. … for the increasing number of people, from epidemiologists to vascular biologists and embryologists, who are looking at homocysteine as part of their research this could provide an invaluable handbook. Why do I think this would be useful? The answer is simple - the large number of people who have walked into my office whilst this book has been lying on my desk and said 'can I take a look at that when you have finished?' Patrick Vallance, Journal of the Royal Society of Medicine

    Review of the hardback: 'This is an extremely comprehensive book encompassing a variety of aspects of this fascinating amino-acid. It has a logical structure; an historical overview precedes sections detailing the biochemistry, physiology and pathology of homocysteine. It aims to provide information for clinicians and scientists over a wide-range of disciplines, and it achieves this admirably … there is no better starting point for anyone wishing to learn more about homocysteine and B vitamin metabolism; clinicians with a particular interest in nutrition and cognition will find that this book provides ample 'food for thought'.' Andrew McCaddon, International Journal of Geriatric Psychiatry

    Review of the hardback: 'This is an attractive book. A pleasure to pick up and read and thorough in its review of the subject area. It is timely and useful … This reviewer appreciated the opportunity of reading it.' Human Genetics

    Review of the hardback: 'The content of this volume is excellent … providing an authoritative up to date review that remains remarkably readable … this volume is highly recommended … and is an essential addition to any medical library.' Bevan Hokin, Australian Journal of Medical Science

    Review of the hardback: ' … a fascinating story, the authors are eminent in their fields and the coverage is authorititive and comprehensive. Here is an excellent reference book for anyone interested in the field. Given the important clinical, scientific, and policy issues raised by the folic acid association … geriatricians really need to know about homocysteine.' John Grimley Evans, Age and Aging

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    Product details

    • Date Published: December 2011
    • format: Paperback
    • isbn: 9781107402423
    • length: 536 pages
    • dimensions: 279 x 210 x 27 mm
    • weight: 1.19kg
    • availability: Available
  • Table of Contents

    1. Introduction: historical overview and recent perspectives David Wilken and Bridget Wilken
    Part I. Biochemistry and Physiology
    Section I. Chemistry:
    2. Practical chemistry of homocysteine and other thiols Donald W. Jacobsen
    3. Biosynthesis and reactions of homocysteine thiolactone Hieronim Jakubowski
    4. Homocysteine and lipid oxidation Jay W. Heinecke
    5. Homocysteine, nitric oxide and nitrosothiols Andrew J. Gow, Fred Cobb and Jonathan S. Stamler
    Section II. Biochemistry and metabolism:
    6. Biosynthesis of S-adenosylmethionine Jose M. Mato, Matias A. Avila and Fernado J. Corrales
    7. S-adenosylmethionine-dependent methyltransferase Steven G. Clarke and Kelly Banfield
    8. S-adenosylhomosysteine hydrolase Sean T. Prigge and Peter K. Chiang
    9. Regulation of homocysteine metabolism James D. Finkelstein
    10. Microbial modeling of human disease: homocysteine metabolism Rowena G. Matthews and Martha L. Ludwig
    11. Folate metabolism Robert J. Cook
    12. Cobalamin-dependent remethylation Ruma V. Banerjee and Horatiu Olteanu
    13. Betaine-dependent remethylation Tim Garrow
    14. The transsulfuration pathway Warren D. Kruger
    Section III. Physiology:
    15. Cellular transport and tissue distribution Brian Fowler
    16. Homocysteine and the kidney John T. Brosnan
    17. Homocysteine and the nervous system Anne M. Molloy and Donald G. Weir
    Section IV. Clinical Chemistry:
    18. Methodologies of testing Karsten Rasmussen and Jan Möller
    19. Methionine loading Nicholas Dudman and Jonathan Silberberg
    Part II. Clinical Dysfunction and Hyperhomocysteinemia
    Section V. Genetic Disorders:
    20. Cystathionine-ß-synthase and its deficiency Jan P. Kraus and Viktor Kozich
    21. Inborn errors of folate and cobalamin metabolism David S. Rosenblatt
    22. Polymorphisms of folate and cobalamin metabolism Rima Rozen
    Section VI. Acquired Disorders:
    23. Folate deficiency Ralph Carmel
    24. Cobalamin deficiency Ralph Carmel
    25. Vitamin B6 deficiency Jesse F. Gregory III
    26. Homocysteine in renal disease Margret Arnadottir and Björn Hultberg
    27. Diseases and drugs associated with hyperhomocysteinemia Henk J. Blom
    28. Lifestyle factors associated with hyperhomocysteinemia Stein Emil Vollset, Helga Refsum, Ottar Nygard and Per Ueland
    Section VII. Clinical Consequences of Hyperhomocysteinemia:
    29. Epidemiology: vascular and thrombotic associations Petra Verhoef and Meir Stampfer
    30. Homocysteine and coronary artery disease Killian Robinson
    31. Homocysteine and cerebrovascular disease J. David Spence and James F. Toole
    32. Peripheral arterial disease Godfried Boers
    33. Venous disease Armando D'Angelo and Chiara Beltrametti
    34. Homocysteine and hemostasis Katherine A. Hajjar
    35. Cellular mechanisms of homocysteine pathogenesis in atherosclerosis Donald W. Jacobsen
    36. Homocysteine and cardiovascular physiology Steven R. Lentz
    37. Homocysteine and human reproduction T. K. A. B. Eskes
    Section VIII. Intervention and Therapy:
    38. Modification of hyperhomocysteinemia John M. Scott
    39. Design of clinical trials to test the homocysteine hypothesis of vascular disease Robert Clarke
    40. What is a desirable homocysteine level? Johan B. Ubbink
    Index.

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    Homocysteine in Health and Disease

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  • Editors

    Ralph Carmel, New York Methodist Hospital

    Donald W. Jacobsen, Cleveland Clinic Foundation

    Contributors

    David Wilken, Bridget Wilken, Donald W. Jacobsen, Hieronim Jakubowski, Jay W. Heinecke, Andrew J. Gow, Fred Cobb, Jonathan S. Stamler, Jose M. Mato, Matias A. Avila, Fernado J. Corrales, Steven G. Clarke, Kelly Banfield, Sean T. Prigge, Peter K. Chiang, James D. Finkelstein, Rowena G. Matthews, Martha L. Ludwig, Robert J. Cook, Ruma V. Banerjee, Horatiu Olteanu, Tim Garrow, Warren D. Kruger, Brian Fowler, John T. Brosnan, Anne M. Molloy, Donald G. Weir, Karsten Rasmussen, Jan Möller, Nicholas Dudman, Jonathan Silberberg, Jan P. Kraus, Viktor Kozich, David S. Rosenblatt, Ralph Carmel, Jesse F. Gregory III, Margret Arnadottir, Björn Hultberg, Henk J. Blom, Stein Emil Vollset, Helga Refsum, Ottar Nygard, Per Ueland, Petra Verhoef, Meir Stampfer, Killian Robinson, J. David Spence, James F. Toole, Godfried Boers, Armando D'Angelo, Chiara Beltrametti, Katherine A. Hajjar, Steven R. Lentz, T. K. A. B. Eskes, John M. Scott, Robert Clarke, Johan B. Ubbink

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