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Methodologies for Metabolomics
Experimental Strategies and Techniques

£124.00

David S. Wishart, Kui Yang, Michael A. Kiebish, Richard W. Gross, Arancha Cebrián, Laura Menchén, Elsa Sánchez-López, Juan Casado-Vela, Santiago Díaz-Moralli, Marta Cascante, Teresa Gómez del Pulgar, Juan Carlos Lacal, J. William Allwood, Catherine L. Winder, Warwick B. Dunn, Royston Goodacre, Ann M. Knolhoff, Peter Nemes, Stanislav S. Rubakhin, Jonathan V. Sweedler, Akos Vertes, Bindesh Shrestha, Ralf J. M. Weber, Mark R. Viant, Ioanna Ntai, Neil L. Kelleher, Kimberly A. Kaplan, Herbert H. Hill, Jr, Bong Chul Chung, Man Ho Choi, Ulrich Braumann, Markus Godejohann, Ron Wehrens, Udo Engelke, Fanny Mochel, Hanne Christine Bertram, Morten Rahr Clausen, Ana M. Gil, Gonçalo Graça, Angelina Goudswaard, Éva Morava, Ron A. Wevers, Christina E. Kostara, Eleni T. Bairaktari, Marie-France Penet, Zaver M. Bhujwalla, Kristine Glunde, Norbert W. Lutz, Patrick J. Cozzone, Craig R. Malloy, Elizabeth Maher, Issac Marin-Valencia, Bruce Mickey, Ralph J. DeBerardinis, A. Dean Sherry, Ralph E. Hurd, Yi-Fen Yen, Albert Chen, Geoffrey S. Payne, Yuen-Li Chung, Martin O. Leach, Martial Piotto, François-Marie Moussallieh, Alessio Imperiale, Malika A. Benahmed, Julien Detour, Jean-Pierre Bellocq, Izzie J. Name, Karim Elbayed, Teresa W.-M. Fan, Andrew N. Lane
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  • Date Published: March 2013
  • availability: Available
  • format: Hardback
  • isbn: 9780521765909

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  • Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

    • Provides examples of using metabolomics methods in other relevant biological applications
    • Clear focus on methods, especially spectroscopic methods
    • Presents state-of-the-art techniques
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    Product details

    • Date Published: March 2013
    • format: Hardback
    • isbn: 9780521765909
    • length: 640 pages
    • dimensions: 254 x 178 x 35 mm
    • weight: 1.32kg
    • contains: 84 b/w illus. 83 colour illus. 37 tables
    • availability: Available
  • Table of Contents

    List of contributors
    Part I. Basic Methodological Strategies in Metabolomic Research:
    1. Exploring the human metabolome by nuclear magnetic resonance spectroscopy and mass spectroscopy
    2. Methodological requirements for lipidomics research
    3. Biological methods for metabolic research
    Part II. Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics:
    4. Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling
    5. Mass spectrometry-based methodologies for single-cell metabolite detection and identification
    6. Direct metabolomics from tissues and cells: laser ablation electrospray ionization for small molecule and lipid characterization
    7. Bioinformatic approaches to processing and annotation of high-resolution mass spectrometry data
    8. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy
    9. Metabolomics using ion mobility mass spectrometry
    10. Metabolomics via biomedical mass spectrometry: from sampling to clinical applications
    Part III. Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics:
    11. Analytical techniques in metabolomics integrating nuclear magnetic resonance spectroscopy and chromatography with mass spectrometry
    12. Chemometric methods in nuclear magnetic resonance-based body fluid analysis
    13. Nuclear magnetic resonance of cerebrospinal fluid: the neurometabolome
    14. Nuclear magnetic resonance-based saliva metabolomics
    15. Nuclear magnetic resonance methods for metabolomic investigation of amniotic fluid
    16. Nuclear magnetic resonance analysis and genetic metabolic disease
    17. Lipid profiling in health and disease
    Part IV. Metabolomic Nuclear Magnetic Resonance Spectroscopy Techniques for Body Tissue Analysis:
    18. Magnetic resonance spectroscopy in investigating the cancer metabolome in preclinical model systems
    19. Phospholipidomics by phosphorous nuclear magnetic resonance spectroscopy of tissue extracts
    20. Carbon-13 nuclear magnetic resonance for analysis of metabolic pathways
    21. Hyperpolarized nuclear magnetic resonance spectroscopy - a new method for metabolomic research
    22. Metabolomic magnetic resonance spectroscopy of human tissues: comparison of in vivo and high-resolution magic angle spinning ex vivo techniques
    23. Reproducible sample preparation and spectrum acquisition techniques for metabolic profiling of human tissues by proton high-resolution magic angle spinning nuclear magnetic resonance
    24. Assignment strategies for nuclear magnetic resonances in metabolomics research
    Index.

  • Editors

    Norbert W. Lutz, University Aix-Marseille, France
    Norbert W. Lutz is Research Professor at the School of Medicine at the University of Aix-Marseille, France. He has previously held positions at the Johns Hopkins University School of Medicine, the German Cancer Research Center, the University of Arizona Cancer Center and other internationally renowned research institutions. His research is primarily focused on the analysis of metabolic processes in cancer and in neurological diseases. His papers have appeared in Analytical Chemistry, Annals of Neurology, PLoS ONE, International Journal of Cancer, AIDS, Metabolomics, NMR in Biomedicine and other journals.

    Jonathan V. Sweedler, University of Illinois, Urbana-Champaign
    Jonathan V. Sweedler is the James R. Eiszner Family Professor of Chemistry and the Director of the School of Chemical Sciences at the University of Illinois at Urbana-Champaign, USA. His major research efforts involve developing new approaches for small-volume peptidomics and metabolomics and the application of these technologies to study novel neuro-chemical pathways. Professor Sweedler has published more than 350 manuscripts, book chapters and reviews and has presented 350 invited lectures relate to research in these areas. He is Editor-in-Chief of Analytical Chemistry.

    Ron A. Wevers, University Medical Center Nijmegen, The Netherlands
    Ron Wevers is head of the laboratory of Genetic Endocrine and Metabolic Diseases of the Radboud University Nijmegen Medical Centre in the Netherlands. He has a chair in Clinical Chemistry of Inborn Errors of Metabolism. Professor Wevers is also a member of the Dutch Health Council. He has co-authored more than 300 peer-reviewed papers and many book chapters and wrote a handbook on body fluid NMR spectroscopy in patients with inborn errors of metabolism.

    Contributors

    David S. Wishart, Kui Yang, Michael A. Kiebish, Richard W. Gross, Arancha Cebrián, Laura Menchén, Elsa Sánchez-López, Juan Casado-Vela, Santiago Díaz-Moralli, Marta Cascante, Teresa Gómez del Pulgar, Juan Carlos Lacal, J. William Allwood, Catherine L. Winder, Warwick B. Dunn, Royston Goodacre, Ann M. Knolhoff, Peter Nemes, Stanislav S. Rubakhin, Jonathan V. Sweedler, Akos Vertes, Bindesh Shrestha, Ralf J. M. Weber, Mark R. Viant, Ioanna Ntai, Neil L. Kelleher, Kimberly A. Kaplan, Herbert H. Hill, Jr, Bong Chul Chung, Man Ho Choi, Ulrich Braumann, Markus Godejohann, Ron Wehrens, Udo Engelke, Fanny Mochel, Hanne Christine Bertram, Morten Rahr Clausen, Ana M. Gil, Gonçalo Graça, Angelina Goudswaard, Éva Morava, Ron A. Wevers, Christina E. Kostara, Eleni T. Bairaktari, Marie-France Penet, Zaver M. Bhujwalla, Kristine Glunde, Norbert W. Lutz, Patrick J. Cozzone, Craig R. Malloy, Elizabeth Maher, Issac Marin-Valencia, Bruce Mickey, Ralph J. DeBerardinis, A. Dean Sherry, Ralph E. Hurd, Yi-Fen Yen, Albert Chen, Geoffrey S. Payne, Yuen-Li Chung, Martin O. Leach, Martial Piotto, François-Marie Moussallieh, Alessio Imperiale, Malika A. Benahmed, Julien Detour, Jean-Pierre Bellocq, Izzie J. Name, Karim Elbayed, Teresa W.-M. Fan, Andrew N. Lane

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