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Mechanisms of Disease
An Introduction to Clinical Science

2nd Edition

$91.99 (G)

Julian R. E. Davis, Timothy M. Cox, J. Shaker, P. G. McTernan, Sudesh Kumar, Anthony A. P. Weetman, Richard S. H. Pumphrey, Stephen D. Lawn, George E. Griffin, E. M. Molyneux, Anthony M. Heagerty, Ludwig Neyses, M. H. Buch, Craig J. Smith, Jerard Ross, Nancy J. Rothwell, Pippa J. Tyrell, A. Greenstein, M. Mojaddidi, A. J. M. Boulton, Rayaz A. Malik, W. Mansoor, James Neuberger, Michael E. J. Lean, Nick Payne, David Yates, Elspeth Guthrie
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  • Date Published: April 2008
  • availability: In stock
  • format: Paperback
  • isbn: 9780521523189

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About the Authors
  • To reflect the changing face of undergraduate and postgraduate medical education, this new edition emphasises the principles of disease processes and their underlying mechanisms, bringing the content up to date with the latest developments from the fields of molecular and cellular biology. The focus is on describing the fundamental features of pathophysiological processes with examples to illustrate the similar mechanisms underlying apparently diverse clinical conditions. By understanding the cellular interactions in one disease area, similar principles can be applied to other disease groups and to the scientific basis of medical management and treatment strategies. Throughout, the student is encouraged to evaluate and integrate the evidence critically, developing skills for self-directed learning and the application of knowledge. To further encourage the reader to integrate the theory with clinical practice, each chapter concludes with a series of clinical scenarios and MCQs, with answers provided.

    • Reflects the latest approaches to undergraduate and postgraduate medical education
    • Describes a mechanistic and principle-based approach to understanding disease processes
    • Includes self-test questions, answers and case examples
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    Reviews & endorsements

    '… a refreshing and innovative attempt to allow clinical scientists access and input to medical students at an early stage and provide a true understanding of the cause rather than effect of disease. A brave new book for a brave new world … might well sweep this text to the top of most students' book list.' British Medical Journal

    'This is a handsomely bound and weighted 'introduction to clinical science' based on an excellent idea.' The Endocrinologist

    '… an excellent introductory section on molecular and cell biology … the chapters are easy to read and well illustrated.' Australian and New Zealand Journal of Medicine

    'This is a well organised and illustrated book. The concepts are presented in a straightforward manner, keeping the minutiae to a minimum. I would highly recommend this for beginners in physiology and biochemistry as it is one of the better introductory books available.' Doody's Book Review

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    Product details

    • Edition: 2nd Edition
    • Date Published: April 2008
    • format: Paperback
    • isbn: 9780521523189
    • length: 340 pages
    • dimensions: 246 x 189 x 16 mm
    • weight: 0.756kg
    • contains: 113 b/w illus.
    • availability: In stock
  • Table of Contents

    1. Molecular and cell biology Julian R. E. Davis
    2. Hereditary disease Timothy M. Cox
    3. Obesity J. Shaker, P. G. McTernan and Sudesh Kumar
    4. Autoimmune mechanisms Anthony A. P. Weetman
    5. Allergy: anaphylaxis Richard S. H. Pumphrey
    6. Infection - Bacteria Stephen D. Lawn and George E. Griffin
    7. Infection - Parasite E. M. Molyneux
    8. The acute coronary syndrome Anthony M. Heagerty
    9. Heart failure Ludwig Neyses and M. H. Buch
    10. Acute neurodegeneration: cerebral ischaemia and stroke Craig J Smith, Jerard Ross, Nancy J. Rothwell and Pippa J. Tyrell
    11. Diabetic neuropathy A. Greenstein, M. Mojaddidi, A. J. M. Boulton and Rayaz A. Malik
    12. Renal cell carcinoma W. Mansoor
    13. Toxic mechanisms James Neuberger
    14. Diet, health and disease Michael E. J. Lean
    15. Trauma Nick Payne and David Yates
    16. The interaction between organic and psychiatric disease Elspeth Guthrie.

  • Editors

    Stephen Tomlinson, University of Wales College of Medicine
    Stephen Tomlinson is Vice-Chancellor of the University of Wales College of Medicine, UK.

    Anthony M. Heagerty, Manchester Royal Infirmary, University of Manchester
    Anthony M. Heagerty is Head of the Cardiovascular Research Division, Department of Medicine, University of Manchester, UK.

    Anthony P. Weetman, University of Sheffield
    Anthony P. Weetman is Professor of Medicine and Dean of the Medical School, University of Sheffield, UK.

    Rayaz A. Malik, University of Manchester
    Rayaz Malik is Senior Lecturer and Consultant Physician, Academic Department of Medicine, Manchester Royal Infirmary, UK.

    Contributors

    Julian R. E. Davis, Timothy M. Cox, J. Shaker, P. G. McTernan, Sudesh Kumar, Anthony A. P. Weetman, Richard S. H. Pumphrey, Stephen D. Lawn, George E. Griffin, E. M. Molyneux, Anthony M. Heagerty, Ludwig Neyses, M. H. Buch, Craig J. Smith, Jerard Ross, Nancy J. Rothwell, Pippa J. Tyrell, A. Greenstein, M. Mojaddidi, A. J. M. Boulton, Rayaz A. Malik, W. Mansoor, James Neuberger, Michael E. J. Lean, Nick Payne, David Yates, Elspeth Guthrie

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