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Methods in Molecular Biophysics

Structure, Dynamics, Function for Biology and Medicine

2nd edition (current edition)

Nathan R. Zaccai, University of Cambridge, Igor N. Serdyuk, Formerly of the Institute of Protein Research, Pushchino, Moscow Region, Joseph Zaccai, Institut Laue-Langevin
Textbook
Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy,…
Frontmatter
pp i-iv
Dedication
pp v-vi
Contents
pp vii-xviii
Preface to the First Edition
pp xix-xx
By Igor N. Serdyuk, Institute of Protein Research, Pushchino, Russia, Nathan R. Zaccai, University of Cambridge, Joseph Zaccai, Institut de Biologie Structurale, Grenoble
Preface to the Second Edition
pp xxi-xxii
By Nathan R. Zaccai, University of Cambridge, Joseph Zaccai, Institut de Biologie Structurale, Grenoble
Introduction: Molecular Biophysics at the Beginning of the Twenty-First Century: From Ensemble Measurements to Single-Molecule Detection
pp 1-10
Part A - BIOLOGICAL MACROMOLECULES AND PHYSICAL TOOLS
pp 11-12
A1 - Macromolecules in Their Environment
pp 13-24
A2 - Macromolecules as Physical Particles
pp 25-42
A3 - Understanding Macromolecular Structures
pp 43-68
Part B - MASS SPECTROMETRY
pp 69-70
B1 - Mass and Charge
pp 71-84
B2 - Structure Function Studies
pp 85-112
Part C - THERMODYNAMICS
pp 113-114
C1 - Thermodynamic Stability and Interactions
pp 115-125
C2 - Differential Scanning Calorimetry
pp 126-140
C3 - Isothermal Titration Calorimetry
pp 141-148
C4 - Surface Plasmon Resonance and Interferometry-Based Biosensors
pp 149-158
Part D - HYDRODYNAMICS
pp 159-160
D1 - Biological Macromolecules as Hydrodynamic Particles
pp 161-183
D2 - Analytical Ultracentrifugation
pp 184-214
D3 - Fluorescence Depolarization
pp 215-228
D4 - Dynamic Light Scattering and Fluorescence Correlation Spectroscopy
pp 229-250
Part E - OPTICAL SPECTROSCOPY
pp 251-252
E1 - Visible and IR Absorption Spectroscopy
pp 253-280
E2 - Two-Dimensional IR Spectroscopy
pp 281-287
E3 - Raman Scattering Spectroscopy
pp 288-305
E4 - Optical Activity and Circular Dichroïsm
pp 306-322
Part F - OPTICAL MICROSCOPY
pp 323-324
F1 - Light Microscopy
pp 325-334
F2 - Single Molecule Manipulation and Atomic Force Microscopy
pp 335-383
F3 - Fluorescence Microscopy
pp 384-404
Part G - X-RAY AND NEUTRON DIFFRACTION
pp 405-406
G1 - The Macromolecule as a Radiation Scattering Particle
pp 407-422
G2 - Small-Angle Scattering and Reflectometry
pp 423-455
G3 - X-ray and Neutron Macromolecular Crystallography
pp 456-486
Part H - ELECTRON DIFFRACTION
pp 487-488
H1 - Electron Microscopy
pp 489-501
H2 - Three-Dimensional Reconstruction from Two-Dimensional Images
pp 502-518
Part I - MOLECULAR DYNAMICS
pp 519-520
I1 - Energy and Time Calculations
pp 521-530
I2 - Neutron Spectroscopy
pp 531-542
Part J - NUCLEAR MAGNETIC RESONANCE
pp 543-544
J1 - Distances and Angles from Frequencies
pp 545-565
J2 - Experimental Techniques
pp 566-593
J3 - Structure and Dynamics Studies
pp 594-626
Part K - MEDICAL IMAGING
pp 627-628
K1 - Radiology and Positron Emission Tomography
pp 629-638
K2 - Ultrasound Imaging
pp 639-647
K3 - Magnetic Resonance Imaging
pp 648-657
References
pp 658-671
Author Index
pp 672-675
Subject index
pp 676-684
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2nd edition (current edition)
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Online ISBN: 9781107297227
Published online: 28 May 2018
Hardback ISBN: 9781107056374
Hardback publication date: 18 May 2017

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