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Histiocytic Disorders of Children and Adults
Basic Science, Clinical Features and Therapy

Sheila Weitzman, R. Maarten Egeler, Ronald Jaffe, Tatjana Nikolic, Pieter Leenen, Cristiana Costa, Nicola Annels, Maurizio Arico, S. Scappaticci, Cesare Danesino, Jean Donadieu, Jon Pritchard, Bernice Krafchik, Elena Pope, Scott Walsh, Emanuela De Juli, Thierry Genereau, Alan Saven, Tazi Abdellatif, Jeroen Hiltermann, Roberto Vassallo, Nicole Grois, Helmut Prosch, Daniela Prayer, Hans Lassmann, Helmut Gadner, Stephan Ladisch, Kenneth McClain, Robert Arceci, Riccardo Haupt, Vasanta Nanduri, James Whitlock, Kim Ericson, Bengt Fadeel, Jan-Inge Henter, Gritta Janka, Shinsaku Imashuku, Ronald Laxer, Athimalaipet Ramanan, Rayfel Schneider, David Webb, Penelope Brock, Steven Simms, Elizabeth Kuh, Giulio D'Angio
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  • Date Published: February 2011
  • availability: Available
  • format: Paperback
  • isbn: 9780521184168

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  • As a comprehensive reference on all aspects of the histiocytic disorders, Histiocytic Disorders of Children and Adults stands out a seminal text on the genetics, pathophysiology and clinical management of this wide range of diseases. The chapters, written by acknowledged experts in the field, cover all aspects of hystiocytic disorders, from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are discussed in detail. Originally published in 2005, this book will be a valuable resource to clinicians and researchers who wish to learn more about histiocytic disorders.

    • A valuable resource for all physicians treating adults or children with a histiocytic disorder
    • Written by leading experts in the field
    • Provides a practical approach to diagnosis, treatment and management
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    Product details

    • Date Published: February 2011
    • format: Paperback
    • isbn: 9780521184168
    • length: 456 pages
    • dimensions: 244 x 170 x 23 mm
    • weight: 0.72kg
    • availability: Available
  • Table of Contents

    Part I. Langerhans Cell Histiocytosis:
    1. Introduction to the problem: overview, history, epidemiology and classification Sheila Weitzman and R. Maarten Egeler
    2. The histopathology of Langerhans Cell Histiocytosis Ronald Jaffe
    3. Histiocyte function and the normal immune system Tatjana Nikolic and Pieter Leenen
    4. The immunologic basis of Langerhans Cell Histiocytosis Cristiana Costa, Nicola Annels and R Maarten Egeler
    5. The genetics of Langerhans Cell Histiocytosis Maurizio Arico, S. Scappaticci and Cesare Danesino
    6. Clinical aspects of Langerhans Cell Histiocytosis Jean Donadieu, Jon Pritchard and R. Maarten Egeler
    7. Dermatologic aspects of the Histiocytic disorders Bernice Krafchik, Elena Pope and Scott Walsh
    8. Langerhans Cell Histiocytosis of bone Sheila Weitzman and R. Maarten Egeler
    9. Special aspects of Langerhans Cell Histiocytosis in the adult Maurizio Ariço, Emanuela De Juli, Thierry Genereau and Alan Saven
    10. Adult lung Histiocytosis Tazi Abdellatif, Jeroen Hiltermann and Roberto Vassallo
    11. Central nervous system involvement in Langerhans Cell Histiocytosis Nicole Grois, Helmut Prosch, Daniela Prayer and Hans Lassmann
    12. The treatment of Langerhans Cell Histiocytosis Helmut Gadner and Stephan Ladisch
    13. Novel and salvage therapies in Langerhans Cell Histiocytosis Sheila Weitzman, Kenneth McClain and Robert Arceci
    14. Late effects of Langerhans Cell Histiocytosis and malignancy and LCH Riccardo Haupt, Vasanta Nanduri and R. Maarten Egeler
    15. Uncommon Histiocytic disorders Sheila Weitzman and James Whitlock
    Part II. Histiocytic Disorders Involving the Monocyte/Macrophage Pathway:
    16. The histopathology of haemophagocytic lymphohistiocytosis Ronald Jaffe
    17. Genetics and pathogenesis of hemophagocytic lymphohistiocytosis Kim Ericson, Bengt Fadeel and Jan-Inge Henter
    18. Clinical aspects and therapy of hemophagocytic lymphohistiocytosis Gritta Janka, Jan-Inge Henter and Shinsaku Imashuku
    19. Macrophage activation syndrome Ronald Laxer, Athimalaipet Ramanan and Rayfel Schneider
    20. Malignant diseases of the mononuclear phagocytic system David Webb and Penelope Brock
    21. Psychosocial aspects of the Histiocytic disorders Steven Simms, Elizabeth Kuh and Giulio D'Angio.

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    Histiocytic Disorders of Children and Adults

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  • Editors

    Sheila Weitzman, University of Toronto

    R. Maarten Egeler, Rijksuniversiteit Leiden, The Netherlands

    Contributors

    Sheila Weitzman, R. Maarten Egeler, Ronald Jaffe, Tatjana Nikolic, Pieter Leenen, Cristiana Costa, Nicola Annels, Maurizio Arico, S. Scappaticci, Cesare Danesino, Jean Donadieu, Jon Pritchard, Bernice Krafchik, Elena Pope, Scott Walsh, Emanuela De Juli, Thierry Genereau, Alan Saven, Tazi Abdellatif, Jeroen Hiltermann, Roberto Vassallo, Nicole Grois, Helmut Prosch, Daniela Prayer, Hans Lassmann, Helmut Gadner, Stephan Ladisch, Kenneth McClain, Robert Arceci, Riccardo Haupt, Vasanta Nanduri, James Whitlock, Kim Ericson, Bengt Fadeel, Jan-Inge Henter, Gritta Janka, Shinsaku Imashuku, Ronald Laxer, Athimalaipet Ramanan, Rayfel Schneider, David Webb, Penelope Brock, Steven Simms, Elizabeth Kuh, Giulio D'Angio

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