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Dementia with Lewy Bodies

Dementia with Lewy Bodies
Clinical, Pathological, and Treatment Issues


  • Editors:
  • Robert Perry, Department of Neuropathology, Newcastle General Hospital
  • Ian McKeith, University of Newcastle upon Tyne
  • Elaine Perry, MRC Neurochemical Pathology Unit, Newcastle General Hospital
  • Date Published: March 1997
  • availability: In stock
  • format: Hardback
  • isbn: 9780521561884

£ 184.00

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About the Authors
  • Dementia with Lewy bodies (DLB) is perhaps the second most common cause of degenerative dementia after Alzheimer's disease. This book, which represents the first authoritative statement about DLB, arises from a workshop held in Newcastle, England, in October 1995, which brought together leading investigators with clinical and research experience of this condition. It includes review articles, case studies and recent research findings from the main centres studying DLB. Covering the classification, cognitive manifestations, clinical diagnosis, epidemiology, genetics, neuropathology, neurochemistry and treatment of DLB, this is a landmark publication in clinical neuroscience. It presents new operational criteria for research on DLB, and will interest all concerned with the problem of dementia in the elderly.

    • The first authoritative statement about a common form of dementia in the elderly
    • Eminent worldwide authorship - comprehensive coverage
    • Interdisciplinary account of a new diagnostic entity, containing operational criteria for future research
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    Product details

    • Date Published: March 1997
    • format: Hardback
    • isbn: 9780521561884
    • length: 541 pages
    • dimensions: 235 x 158 x 34 mm
    • weight: 0.905kg
    • contains: 53 b/w illus. 9 colour illus. 1 map 57 tables
    • availability: In stock
  • Table of Contents

    1. Introduction
    Part I. Clinical Issues:
    2. The clinical diagnosis and misdiagnosis of Lewy body dementia
    3. The nosological status of Lewy body dementia
    4. Putative clinical and genetic antecedents of dementia associated with Parkinson's disease
    5. Clinical features of patients with Alzheimer's disease and Lewy bodies
    6. The nature of the cognitive decline in Lewy body dementia
    7. Non-cognitive symptoms in Lewy body dementia
    8. Hallucinations, cortical Lewy body pathology, cognitive function and neuroleptic use in dementia
    9. Neuropsychological aspects of Lewy body dementia
    10. The neuroanatomical basis of cognitive deficits in Lewy body dementia
    11. The clinical and functional imaging characteristics of Parkinsonian-dementia
    12. Positron emission tomography findings in Parkinson's disease and Lewy body dementia
    13. Clinical features of diffuse Lewy body disease in the elderly: analysis of 12 cases
    14. Senile dementia of Lewy body type - clinical features and prevalence in neuropathological postmortems
    15. Lewy body dementia in clinical practice
    resume of clinical workshop sessions
    Part II. Pathological Issues:
    16. Pathological significance of Lewy bodies in dementia
    17. Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies
    18. What is the neuropathological basis of dementia associated with Lewy bodies?
    19. Cytoskeletal and Alzheimer-type pathology in Lewy body disease
    20. Diffuse Lewy body disease within the spectrum of Lewy body disease
    21. Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease and senile dementia of Alzheimer type
    22. Pathological and clinical features of Parkinson's disease with and without dementia
    23. Dementia with Lewy bodies: relationship to Parkinson's and Alzheimer's diseases
    24. What do Lewy bodies tell us about dementia and Parkinsonism?
    25. Pathogenesis of the Lewy body
    26. Altered tau processing: its role in development of dementia in Alzheimer's disease and Lewy body disease
    27. Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia - an epiphenomenon?
    28. Genetic correlations in Lewy body disease
    resume of pathological workshop sessions
    Part III. Treatment Issues:
    29. Psychopharmacology of cognitive impairment in Parkinson's disease
    30. Management of the non-cognitive symptoms of Lewy body dementia
    31. Altered consciousness and transmitter signalling in Lewy body dementia
    32. Cholinergic therapy and Lewy body dementia
    33. Clinical heterogeneity in dementia
    responders to cholinergic therapy
    34. Tacrine and symptomatic treatment in Lewy body dementia
    35. Neurochemical correlates of pathological and iatrogenic extrapyramidal symptoms
    36. Neurotrophins and the cholinergic system in dementia
    37. Relevance of Lewy bodies to alterations in oxidative stress in Lewy body dementia and Parkinson's disease
    Resume of treatment workshop Sessions

  • Editors

    Robert Perry, Department of Neuropathology, Newcastle General Hospital

    Ian McKeith, University of Newcastle upon Tyne

    Elaine Perry, MRC Neurochemical Pathology Unit, Newcastle General Hospital


    Jeffrey L. Cummings

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