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What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.Read more
- Explains challenging and complex concepts in an accessible way to enable the reader to engage critically with current, often inaccurate, representations of what genes are and what they can and cannot do
- Provides an inter-disciplinary overview, combining perspectives from a wide range of fields with current genetics and genomics research to provide a pragmatic view of genes
- Discusses the uses of metaphors in science and how these should and should not be used
Reviews & endorsements
'A beautifully and lucidly written book of great insights … I have not seen in one volume such clear analysis of the nuanced view of the 'gene' … A valuable book that gives genes a new and accurate meaning and does justice to understanding genetics in a non-reductive [manner] through a systems approach. The clarity, precision and insights are wonderful.' Sheldon Krimsky, Tufts University, MassachusettsSee more reviews
'… an extremely intellectual and erudite treatment of the history and meaning of genes and genomes. The book is half hard-core genetics and half provocative and fascinating philosophy of science … cogently written, highly informative and genuinely thought-provoking.' John Avise, University of California
'… it is really marvelous: very clearly written, very thoughtfully structured and marvellously sensitive to the needs of the reader, especially in providing 'take-home message' summaries just when and where they are most welcome. I especially admired the way the author consistently manages to help the reader dial down expectations when faced with hype about genetic tests and the latest 'gene for' discoveries.' Gregory Radick, University of Leeds
'There is a vast and curious mismatch between what biological science has discovered by empirical investigations on the mechanisms of heredity and the understanding of what appears to be the central concept, that of the gene. Despite careful attempts to show both the nature and the significance of this gap, the scientific media, and public perceptions of the concept, persistently follow a successfully popularized view that is not justified by what we now know. Kampourakis’ book is an excellent attempt to correct the situation … by bringing impressive scholastic skills to tackle the problem, the author has in my view made a very major contribution. The book deserves very wide attention.' Denis Noble, University of Oxford
'Kampourakis provides an excellent critical analysis of the genetic discourse at the intersection of science and the public, based on the latest scientific findings from genomics and systems biology. The book fills an important gap in the literature in terms of the balance it keeps between accessibility and scientific rigour. It calls for a change in the ways students and the public are told what genes are and what they do, and it does so with compelling persuasiveness. A must-read, packed with convincing empirical material, for educators, journalists and academics who are critical of the usual 'gene for' talk, but do not want to give up on the fascinating insights that the science of genetics provides.' Staffan Müller-Wille, University of Exeter
'… a wonderfully engaging and pedagogical explanation of difficult concepts in biology … Kampourakis has an incredible feeling for how to strike the balance between biological material and conceptual analysis. … If you are teaching life sciences or engaging in any form of public outreach, this book is a must-read. … Throughout, the material is wonderfully up to date … this important book will help us to explain genetics to our friends, students, and fellow academics.' Tobias Uller, Frontiers in Genetics
'… this book addresses the crucial educational and translational science bottlenecks of postgenomics, and delivers on its promise to the readers to move beyond the gene sequence to broader sense making for human genetics and genomics.' George P. Patrinos, OMICS: A Journal of Integrative Biology
'Kampourakis describes concisely how the late 20th century saw a revision in our view of what a gene really is. … [He] comes down hard on the hype surrounding 'decoding the book of life', as well as [those] who did not understand the relationship between DNA sequences and complex characters. … [the book] provides a useful companion to biology undergraduates and the interested layperson will find it informative in its critique of naïve genetic determinism. I would certainly recommend it.' Charalambos P. Kyriacou, BioEssays
'It is not news to most geneticists and those who teach genetics at the college level, for whom this book is mainly pitched, that misconceptions about genes abound in public discourse and in the popular mind. In Making Sense of Genes, Kostas Kampourakis sets out the evidence for this and then carefully and comprehensively unpacks the details of what genes do and do not do. … [W]ith many detailed case studies, Kampourakis dismantles the 'genes for' concept for characters and disorders … In the context of the population and environment, genetic differences among individuals can help explain, not entire phenotypes, but phenotype differences among individuals. In terms of how to frame genetics content for students, this may be the most concise and important take-home message of the book. … a useful and informative refresher and reminder that, for the public, sense can be made of genes if geneticists are clear about concepts and contexts, and realistic about interpretations and implications of their research.' John R. True, The Quarterly Review of Biology
'Making Sense of Genes is an elegantly written book containing many refreshing insights about how the notion of the gene was developed in the late 19th century and how it is used and misused today. … Rather than depending on facile metaphors for gene function ('blueprints', 'programs') like most other popular treatments of biology, the author, Kostas Kampourakis, deftly deconstructs them, showing why they have been adopted, but how they mislead. He convincingly shows that while the notion that there are genes 'for' specific characters, such as height or aggressive behavior, is based on multiple misconceptions, the idea of genes 'for' some diseases, including metabolic disorders and cancers, may have some merit, even though strict causation is rarely straightforward.' Stuart Newman, GeneWatch
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- Date Published: March 2017
- format: Adobe eBook Reader
- isbn: 9781108216074
- contains: 97 b/w illus. 10 tables
- availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
Table of Contents
Prolegomena: genes, science and science fiction
1. Mendel and the origins of the 'gene' concept
2. The genes of classical genetics
3. The molecularization of genes
4. So, what are genes?
5. 'Genes for' (almost) everything
6. Are there 'genes for' characters?
7. Are there 'genes for' diseases?
8. So, what do genes do?
9. Genes are implicated in the development of characters
10. Genes account for variation in characters
11. Genomes are more than the sum of genes
12. Limitations in the study of genomes
Concluding remarks: how to think and talk about genes?
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