Systems Biology
Properties of Reconstructed Networks
$89.99 (P)
- Author: Bernhard Ø. Palsson, University of California, San Diego
- Date Published: January 2006
- availability: Available
- format: Hardback
- isbn: 9780521859035
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Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education.
Read more- The first textbook in the new field of systems biology
- An associated website provides slides, projects and problems
- Features an open layout, summary points, guides to literature and lots of illustrations
Reviews & endorsements
"Systems Biology is a very readable introduction to the subject... make[s] it clear that this is an exciting time for biology."
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×Product details
- Date Published: January 2006
- format: Hardback
- isbn: 9780521859035
- length: 336 pages
- dimensions: 261 x 20 x 181 mm
- weight: 0.8kg
- availability: Available
Table of Contents
Preface
1. Introduction
2. Basic concepts in systems biology
Part I. Reconstruction of Biochemical Networks:
3. Metabolic networks
4. Regulatory networks
5. Signalling networks
Part II. Mathematical Representation of Reconstructed Networks:
6. Basic features of S
7. Topological properties
8. Fundamental subspaces
9. Null space of S
10. The left null space of S
11. The row and column spaces of S
Part III. Capabilities of Reconstructed Networks:
12. Dual causality
13. Properties of solution spaces
14. Sampling properties of solution spaces
15. Finding functional states
16. Parametric sensitivity
17. Epilogue
Appendix A: nomenclature and abbreviations
Appendix B: E. coli core metabolic network
Bibliography
Index.
related journals
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