Other available formats:
Looking for an examination copy?
If you are interested in the title for your course we can consider offering an examination copy. To register your interest please contact email@example.com providing details of the course you are teaching.
Biophysical models have been used in biology for decades, but they have been limited in scope and size. In this book, Bernhard Ø. Palsson shows how network reconstructions that are based on genomic and bibliomic data, and take the form of established stoichiometric matrices, can be converted into dynamic models using metabolomic and fluxomic data. The Mass Action Stoichiometric Simulation (MASS) procedure can be used for any cellular process for which data is available and allows a scalable step-by-step approach to the practical construction of network models. Specifically, it can treat integrated processes that need explicit accounting of small molecules and protein, which allows simulation at the molecular level. The material has been class-tested by the author at both the undergraduate and graduate level. All computations in the text are available online in MATLAB and MATHEMATICA® workbooks, allowing hands-on practice with the material.Read more
- Shows how dynamic models are built and simulated in the modern omics era
- Provides a unified framework that allows the treatment of metabolites, enzymes and binding protein simultaneously
- Material for instructors and students is available from http://systemsbiology.ucsd.edu
Not yet reviewed
Be the first to review
Review was not posted due to profanity×
- Date Published: June 2011
- format: Hardback
- isbn: 9781107001596
- length: 332 pages
- dimensions: 254 x 182 x 25 mm
- weight: 0.8kg
- contains: 126 b/w illus.
- availability: Available
Table of Contents
2. Basic concepts
Part I. Simulation of Dynamic States:
3. Dynamic simulation: the basic procedure
4. Chemical reactions
5. Enzyme kinetics
6. Open systems
Part II. Biological Characteristics:
7. Orders of magnitude
8. Stoichiometric structure
9. Regulation as elementary phenomena
Part III. Metabolism:
11. Coupling pathways
12. Building networks
Part IV. Macromolecules:
14. Regulated enzymes
B. Homework problems
Find resources associated with this titleYour search for '' returned .
Type Name Unlocked * Format Size
This title is supported by one or more locked resources. Access to locked resources is granted exclusively by Cambridge University Press to instructors whose faculty status has been verified. To gain access to locked resources, instructors should sign in to or register for a Cambridge user account.
Please use locked resources responsibly and exercise your professional discretion when choosing how you share these materials with your students. Other instructors may wish to use locked resources for assessment purposes and their usefulness is undermined when the source files (for example, solution manuals or test banks) are shared online or via social networks.
Supplementary resources are subject to copyright. Instructors are permitted to view, print or download these resources for use in their teaching, but may not change them or use them for commercial gain.
If you are having problems accessing these resources please contact firstname.lastname@example.org.
Sorry, this resource is locked
Please register or sign in to request access. If you are having problems accessing these resources please email email@example.comRegister Sign in
You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner www.ebooks.com. Please see the permission section of the www.ebooks.com catalogue page for details of the print & copy limits on our eBooks.Continue ×