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Handbook of Iron Overload Disorders

$162.00 ( ) USD

  • Date Published: August 2010
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9780511771460

$ 162.00 USD ( )
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  • A practical, clinically-oriented handbook of iron overload disorders giving a compact guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Many of these disorders were discovered and characterized only in the last decade, and are unmentioned or inadequately described in most texts. Written by clinicians for clinicians, this handbook summarizes information on diverse iron overload conditions, including their history, signs, symptoms, and physical examination findings, genetics, genotype-phenotype correlations, pathophysiology, differential diagnosis and treatment. Most physicians, regardless of specialty, encounter patients with systemic or organ-specific iron overload conditions. This book contains essential information for practising adult and pediatric medical specialists in the fields of hematology, gastroenterology, hepatology, rheumatology, endocrinology, diabetology, neurology, oncology, dermatology, and internal medicine. Pathologists, pharmacologists, geneticists, genetic counselors, and epidemiologists will also find substantial, up-to-date sections in this handbook that are pertinent to their respective fields of interest.

    • A substantial and up-to-date yet compact guide, written for clinicians by clinicians
    • Supplemented with clinical images, pedigrees, photomicrographs, illustrative cartoons, tables, and literature references
    • Detail provides all necessary information to enable accurate assessment, quick diagnosis and effective treatment
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    Product details

    • Date Published: August 2010
    • format: Adobe eBook Reader
    • isbn: 9780511771460
    • contains: 51 b/w illus. 8 colour illus. 61 tables
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    Foreword
    Preface
    1. History of iron overload disorders
    2. Normal iron absorption and metabolism
    3. Iron toxicity
    4. Tests for hemochromatosis and iron overload
    5. Complications of hemochromatosis and iron overload
    6. Insulin resistance and iron overload
    7. Infections and immunity
    8. Classical and atypical hfe hemochromatosis
    9. Heterozygosity for hfe c282y
    10. Porphyria cutanea tarda
    11. Mitochondrial mutations as modifiers of hemochromatosis
    12. Hemochromatosis associated with ferroportin gene (slc40a1) mutations
    13. Hemochromatosis associated with hemojuvelin gene (hjv) mutations
    14. Hemochromatosis associated with hepcidin gene (hamp) mutations
    15. Hemochromatosis associated with transferrin receptor-2 gene (tfr2) mutations
    16. Iron overload associated with ire mutation of ferritin heavy-chain gene (fth1)
    17. Hereditary hyperferritinemia-cataract syndrome: ire mutations of ferritin light chain gene (ftl)
    18. Iron overload in native Africans and African Americans
    19. Hereditary atransferrinemia
    20. Divalent metal transporter-1 (dmt1) iron overload
    21. Iron overload associated with thalassemia syndromes
    22. Iron overload associated with hemoglobinopathies
    23. Iron overload associated with pyruvate kinase deficiency
    24. Iron overload associated with congenital dyserythropoietic anemias
    25. Hereditary sideroblastic anemias
    26. Pearson marrow-pancreas syndrome
    27. Acquired sideroblastic anemias
    28. Hereditary aceruloplasminemia
    29. Friedreich ataxia and cardiomyopathy
    30. Pantothenate kinase (pank2)-associated neurodegeneration
    31. Neuroferritinopathies
    32. Gracile syndrome
    33. Neonatal hemochromatosis
    34. Iron overload due to excessive supplementation
    35. Localized iron overload
    36. Management of iron overload
    37. Population screening for hemochromatosis
    38. Ethical, legal, and social issues
    39. Directions for future research
    Index.

  • Authors

    James C. Barton, University of Alabama, Birmingham
    James C. Barton is Medical Director, Southern Iron Disorders Center and Clinical Professor, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

    Corwin Q. Edwards, University of Utah Medical Center
    Corwin Q. Edwards is Director of Graduate Medical Education, Intermountain Medical Center and LDS Hospital, Professor of Medicine, Associate Director, Internal Medicine Training Program, University of Utah School of Medicine, Salt Lake City, Utah, USA.

    Pradyumna D. Phatak, University of Rochester Medical Center, New York
    Pradyumna D. Phatak is Head, Hematology/Medical Oncology Unit, Rochester General Hospital, Rochester, and Clinical Professor of Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.

    Robert S. Britton, Saint Louis University School of Medicine
    Robert S. Britton is Associate Research Professor, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

    Bruce R. Bacon, Saint Louis University School of Medicine
    Bruce R. Bacon is Director, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

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