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The Clozapine Handbook
Stahl's Handbooks

$49.99 (G)

Part of Stahl's Essential Psychopharmacology Handbooks

  • Date Published: May 2019
  • availability: In stock
  • format: Paperback
  • isbn: 9781108447461
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$ 49.99 (G)

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About the Authors
  • Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.

    • The increased interest in promoting greater clozapine use internationally means this book fills a gap in the market for clinicians who seek evidence-based advice on best practices
    • Use of clozapine has shown real world benefits such as a reduction in suicidality, psychiatric hospitalization and mortality rates; many clinicians are unfamiliar with recent improvements in the understanding of clozapine-related dosing and adverse effect management
    • Provides a logical, evidence-based framework for important clinical issues, leading the clinician through the reasoning process for adverse effect management and other common clinical situations
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    Customer reviews

    24th May 2019 by ESchwartz

    The Clozapine Handbook is a super useful reference that can give any psychiatrist the expertise they need to to prescribe clozapine confidently. The book provides a high level of clinically relevant information that is not provided in most psychiatric residencies. This handbook is now the most up-to-date and clinically relevant clozapine reference in the world. There is nothing else like it. The book is well-indexed so it is very easy to locate specific information on just about any topic related to clozapine. There are helpful tables, graphs and summary boxes. The book contains everything from the history of clozapine, how to initiate and titrate clozapine, what you need to know about clozapine metabolism and drug interactions, how to monitor clozapine plasma levels, how to monitor for potential adverse side effects and how to effectively manage bothersome side effects to keep your patients on clozapine like a world class psychopharmacologist!

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    Product details

    • Date Published: May 2019
    • format: Paperback
    • isbn: 9781108447461
    • length: 326 pages
    • dimensions: 186 x 123 x 14 mm
    • weight: 0.36kg
    • contains: 24 b/w illus.
    • availability: In stock
  • Table of Contents

    1. Initiating Clozapine
    2. Understanding hematologic monitoring and benign ethnic neutropenia
    3. Binding profile, metabolism, kinetics, drug interactions and use of plasma levels
    4. Managing constipation
    5. Managing sialorrhea
    6. Managing sedation, orthostasis and tachycardia
    7. Managing metabolic adverse effects
    8. Managing seizure risk and stuttering
    9. Fever, myocarditis, interstitial nephritis, DRESS, serositis and cardiomyopathy
    10. Eosinophilia, leukocytosis, thrombocytopenia, thrombocytosis, anemia, hepatic function abnormalities
    11. Managing enuresis and incontinence, priapism, venous thromboembolism, neuroleptic malignant syndrome, tardive dyskinesia and obsessive compulsive disorder
    12. The efficacy story: treatment resistant schizophrenia, psychogenic polydipsia, treatment intolerant schizophrenia, suicidality, violence, mania and Parkinson's disease psychosis
    13. Addressing clozapine positive symptom nonresponse in schizophrenia spectrum patients
    14. Discontinuing clozapine and management of cholinergic rebound
    15. Special topics: child and adolescent patients, elderly patients, patients with intellectual disability, pregnancy and risk for major congenital malformation, lactation, overdose, postmortem redistribution

  • Authors

    Jonathan M. Meyer, University of California, San Diego
    Jonathan M. Meyer is currently a Clinical Professor of Psychiatry at the University of California, San Diego and a Psychopharmacology Consultant to the California Department of State Hospitals. Dr Meyer is an internationally recognised speaker on psychopharmacology and the treatment of severe mental illness, and is Distinguished Fellow of the American Psychiatric Association.

    Stephen M. Stahl, University of California, San Diego
    Stephen M. Stahl is currently a Professor at the University of California, San Diego and serves as Honorary Fellow in the psychiatry department at the University of Cambridge. He is also the Chairman of the Neuroscience Education Institute (NEI) and Arbor Scientia Group. Dr Stahl serves as the Director of Psychopharmacology Services at the California Department of State Hospitals as well as the Editor-in Chief of CNS Spectrums.

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