Neurodegenerative Diseases
Neurobiology, Pathogenesis and Therapeutics
Out of Print
- Authors:
- M. Flint Beal, Cornell University, New York
- Anthony E. Lang, University of Toronto
- Albert C. Ludolph, Universität Ulm, Germany
- Date Published: July 2005
- availability: Unavailable - out of print April 2012
- format: Hardback
- isbn: 9780521811668
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Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.
Read more- Largest and most comprehensive reference text on neurodegenerative disease
- Editors and contributors include the world's leading authorities internationally
- Covers basic neuroscience and clinical features
Reviews & endorsements
"Research in this area is a moving target, difficult to capture in a book, but Beal and colleagues have made a worthy effort...a weighty and comprehensive overview with an all-star list of contributors."
Kenneth Fischbeck, New England Journal of MedicineSee more reviews"Neurodegenerative Diseases is one of the most comprehensive books to appear on the subject in the past decade...discusses all the neurodegenerative illnesses, with special attention to biological, pathophysiological, clinical, and therapeutic aspects, rather than focusing on a single facet...a comprehensive, well-written textbook. It is an excellent reference to have and return to again and again as an authoritative source on neurodegeneration."
Journal of the American Medical Association"...there is a large amount of information, which will repay careful reading, perhaps especially for those new to the field. The book has high production values. A highly desirable addition for the departmental library."
Advances in Clinical Neuroscience and Rehabilitation, AJ Larner"This encyclopedic book is a presentation of the totality of neurodegenerative disorders in the form of 62 highly readable essays from more than 100 distinguished contributors. The editors have succeeded with their intent of making this the most authoritative reference source for both clinicians and neuroscientists interested in these important clinical problems. The essays are organized in a coherent and seamless fashion, with every aspect of neurodegeneration considered... every recognized degenerative process of the central nervous system is discussed. The organization of the book is systematic. This resource should be available to any clinician dealing with neurodegenerative disorders or any scientist investigating neurodegeneration. I recommend the book highly and believe it will prove an invaluable resource for individuals interested in this important and devastating group of human illnesses. The price is appropriate and the title is a precise reflection of the contents."
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×Product details
- Date Published: July 2005
- format: Hardback
- isbn: 9780521811668
- length: 1008 pages
- dimensions: 283 x 225 x 51 mm
- weight: 3.2kg
- contains: 102 b/w illus. 39 colour illus. 80 tables
- availability: Unavailable - out of print April 2012
Table of Contents
Part I. Basic Aspects of Neurodegeneration:
1. Endogenous free radicals and antioxidants in the brain
2. Biological oxidants and therapeutic antioxidants
3. Mitochondria, metabolic inhibitors and neurodegeneration
4. Excitotoxicity and excitatory amino acid antagonists in chronic neurodegenerative diseases
5. Glutamate transporters
6. Calcium binding proteins in selective vulnerability of motor neurons
7. Apoptosis in neurodegenerative diseases
8. Neurotrophic factors
9. Protein misfolding and cellular defence mechanisms in neurodegenerative diseases
10. Neurodegenerative disease and the repair of oxidatively damaged DNA
11. Compounds acting on ion channels
12. The role of nitric oxide and PARP in neuronal cell death
13. Copper and zinc in Alzheimer's disease and amyotrophic lateral sclerosis
14. The role of inflammation in Alzheimer's disease neuropathology and clinical dementia: from epidemiology to treatment
15. 15. Selected genetically engineered models relevant to human neurodegenerative disease
16. Toxic animal models
17. A genetic outline of the pathways to cell death in Alzheimer's disease, Parkinson's disease, frontal dementias and related disorders
18. Neurophysiology of Parkinson's disease, levodopa-induced dyskinesias, dystonia, Huntington's disease and Myoclonus
Part II. Neuroimaging in Neurodegeneration:
19. Structural and functional magnetic resonance imaging in neurodegenerative diseases
20. PET/SPECT
21. Magnetic resonance spectroscopy of neurodegenerative illness
Part III. Therapeutic Approaches in Neurodegeneration:
22. Gene therapy
23. Stem cells and cell-based therapy in neurodegenerative disease
24. Necessary methodological and stem cell advances for restoration of the dopaminergic system in Parkinson's disease patients
Part IV. Normal Aging:
25. Clinical aspects of normal aging
26. Neuropathology of normal aging in cerebral cortex
Part V. Alzheimer's Disease:
27. Mild cognitive impairment
28. Alzheimer's disease - overview
29. The neuropathology of Alzheimer's disease in the year 2005
30. Genetics of Alzheimer's disease
31. The role of Beta-amyloid in Alzheimer's disease
32. Treatment of Alzheimer's disease
Part VI. Other Dementias:
33. Dementia with Lewy bodies
34. Frontotemporal lobar degeneration
35. Frontotemporal dementia with Parkinsonism linked to Chromosome 17
36. Prion diseases
Part VII. Parkinson's and Related Movement Disorders:
37. Approach to the patient presenting with Parkinsonism
38. Parkinson's disease
39. Neuropathology of Parkinson's disease
40. Genetics of Parkinsonism
41. Pathophysiology - biochemistry of Parkinson's disease
42. Current and potential treatments of Parkinson's disease
43. Multiple system atrophy
44. Progressive supranuclear palsy
45. Corticobasal degeneration
Part VIII. Cerebellar Degenerations:
46. Approach to the patient with ataxia
47. Autosomal dominant cerebellar ataxia
48. Friedreich's ataxia and other autosomal recessive ataxias
49. Ataxia telangiectasia
Part IX. Motor Neuron Diseases:
50. An approach to the patient with motor neuron dysfunction
51. The genetics of amyotrophic lateral sclerosis
52. Current and potential therapeutics in motor neuron diseases
53. The hereditary spastic paraplegias
54. Spinal and Bulbar muscular atrophy (Kennedy's disease)
55. Spinal muscular atrophies
56. Western Pacific ALS/Parkinsonism-Dementia complex
Part X. Other Neurodegenerative Diseases:
57. Huntington's disease
58. Dentatorubral-pallidoluysian atrophy (DRPLA): model for Huntington's disease and other polyglutamine diseases
59. Neuroacanthocytosis
60. Brain iron disorders
61. Neurological aspects of Wilson's disease
62. Disorders of the mitochondrial respiratory chain
Index.
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