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Gynaecological Cancers
Biology and Therapeutics

$173.00 (G)

Part of Royal College of Obstetricians and Gynaecologists Study Group

W. Glenn McCluggage, Susana Banerjee, Robert Brown, Janet Graham, Christine A. Parkinson, James D. Brenton, Timothy A. Yap, Yvette Drew, Susan Shanley, Richard J. Edmondson, Asima Mukhopadhyay, Aiste Cerbinskaite, Nicola J. Curtin, Yvette Drew, Stan B. Kaye, Tim Mould, Oliver Zivanovic, Dennis S. Chi, Leena Mukherjee, Gordon Rustin, Iain A. McNeish, Andrew Clamp, Ahmed Ashour Ahmed, Stefan Knapp, Anil K. Sood, Robert C. Bast Jr, Nandita M. deSouza, Evis Sala, Stavroula Kyriazi, Andrea Rockall, Christina Fotopoulou, Angus McIndoe, Jalid Sehouli, Hani Gabra, Karen Tipples, Melanie Powell, Tito Lopes
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  • Date Published: June 2011
  • availability: Available
  • format: Paperback
  • isbn: 9781906985448

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About the Authors
  • Gynaecological cancers are categorised as 'rare' diseases, although collectively they affect over 16,000 women each year in the UK alone. There is a lack of real understanding of these conditions compared with other malignancies, possibly owing to their relative rarity when viewed as individual diseases. The 60th RCOG Study Group brought together a range of experts to examine as many biological aspects of gynaecological cancers as possible, including both surgical and non-surgical therapies. This book presents the findings of the Study Group, with contents including: • current understanding of the biology of gynaecological cancers • translation of biology to the clinic • state of the art in imaging and therapy • current clinical trials • advances in multimodal therapy • individualised treatment.

    • The Study Group brings together the most up-to-date research in the field of the biology of and therapeutics for gynaecological cancers
    • A valuable source of reference for anyone working in the field of gynaecological cancers, including practising clinicians, researchers and other interested healthcare practitioners
    • Includes consensus views to inform clinical practice and future research
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    Product details

    • Date Published: June 2011
    • format: Paperback
    • isbn: 9781906985448
    • length: 272 pages
    • dimensions: 234 x 156 x 15 mm
    • weight: 0.42kg
    • availability: Available
  • Table of Contents

    Part I. Biology of Gynaecological Cancers: Our Current Understanding:
    1. Morphological sub-types of ovarian carcinoma: new developments and pathogenesis W. Glenn McCluggage
    2. Novel treatment strategies for targeting genetic changes in endometrial cancer Susana Banerjee
    3. Epigenetic biomarkers in ovarian cancer Robert Brown and Janet Graham
    4. Predictive biology of ovarian cancer Christine A. Parkinson and James D. Brenton
    Part II. The Translation of Biology to the Clinic:
    5. Biology of BRCA1 and BRCA2 genes and implications for cancer management Timothy A. Yap, Yvette Drew and Susan Shanley
    6. Implications of homologous recombination defectiveness in ovarian cancer Richard J. Edmondson, Asima Mukhopadhyay, Aiste Cerbinskaite and Nicola J. Curtin
    7. The future of PARP inhibitors in the treatment of cancer Yvette Drew, Timothy A. Yap and Stan B. Kaye
    Part III. Imaging and Therapy: State of the Art:
    8. The role of robotics and the future Tim Mould
    9. 'Ultra-radical' surgery in advanced ovarian cancer Oliver Zivanovic and Dennis S. Chi
    10. Antivascular therapy in gynaecological cancers Leena Mukherjee and Gordon Rustin
    11. Oncolytic viral gene therapy in ovarian cancer Iain A. McNeish
    12. Endometrial cancer: what have the clinical trials taught us? Andrew Clamp
    13. Targeting therapies in cancer: opportunities in ovarian cancer Ahmed Ashour Ahmed, Stefan Knapp, Anil K. Sood and Robert C. Bast Jr
    14. Functional imaging: from tumour biology to the clinic Nandita M. deSouza, Evis Sala, Stavroula Kyriazi and Andrea Rockall
    Part IV. What Questions Are Being Asked by Current Clinical Trials?:
    15. Current clinical trials in ovarian cancer Christina Fotopoulou, Angus McIndoe, Jalid Sehouli and Hani Gabra
    16. Clinical trials in cervical cancer Karen Tipples and Melanie Powell
    17. Clinical trials in vulval cancer Tito Lopes
    Part V. Consensus Views:
    18. Consensus views arising from the 60th Study Group: Gynaecological Cancers: Biology and Therapeutics
    Index.

  • Editors

    Sean Kehoe, John Radcliffe Hospital, Oxford
    Sean Kehoe works as a Consultant at Churchill Hospital and John Radcliffe Hospital, Oxford. He currently serves on the RCOG Council (as Fellows' Representative South East).

    Richard J. Edmondson, Queen Elizabeth Hospital, Gateshead
    Richard J. Edmondson is a Consultant at Queen Elizabeth Hospital, Gateshead.

    Martin Gore, Institute of Cancer Research, London
    Martin Gore is Medical Director of The Royal Marsden and Professor of Cancer Medicine at The Institute of Cancer Research.

    Iain A. McNeish, Barts and The London School of Medicine, London
    Iain A. McNeish is a cancer specialist at Barts and the London School of Medicine, part of the Barts Cancer Research UK Centre. He is Deputy Director of the Barts Experimental Cancer Medicine Centre.

    Contributors

    W. Glenn McCluggage, Susana Banerjee, Robert Brown, Janet Graham, Christine A. Parkinson, James D. Brenton, Timothy A. Yap, Yvette Drew, Susan Shanley, Richard J. Edmondson, Asima Mukhopadhyay, Aiste Cerbinskaite, Nicola J. Curtin, Yvette Drew, Stan B. Kaye, Tim Mould, Oliver Zivanovic, Dennis S. Chi, Leena Mukherjee, Gordon Rustin, Iain A. McNeish, Andrew Clamp, Ahmed Ashour Ahmed, Stefan Knapp, Anil K. Sood, Robert C. Bast Jr, Nandita M. deSouza, Evis Sala, Stavroula Kyriazi, Andrea Rockall, Christina Fotopoulou, Angus McIndoe, Jalid Sehouli, Hani Gabra, Karen Tipples, Melanie Powell, Tito Lopes

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