Causes of Cancer and Targets for Treatment
$190.00 ( ) USD
- Edward P. Gelmann, Columbia University, New York
- Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, New York
- Frank J. Rauscher, III, The Wistar Institute Cancer Centre, Philadelphia
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The genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target.Read more
- Fully comprehensive: covers molecular changes in a wide range of human cancers, how these are analysed, and molecular therapeutic approaches
- Demonstrates how basic research informs clinical practice and pharmacologic developments
- High-quality team of editors and contributors recruited from some of the leading cancer centers worldwide
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- format: Adobe eBook Reader
- isbn: 9781316345221
- contains: 48 b/w illus. 317 colour illus. 91 tables
- availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
Table of Contents
Part IV. Pharmacologic Targeting of Oncogenic Pathways.
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