Electric Brain Signals
Foundations and Applications of Biophysical Modeling

‘If you love physics, are fascinated with the brain, and wish that neural circuits could be understood from first principles, this book is for you! Gaute Einevoll and his team put together a masterpiece educational resource. Depending on the background and stage of training, the reader can consume it front to back, or use it as a reference book. The first part covers, in detail, the biophysical theory governing generation of the transmembrane and extracellular electrical potential. The second part is a comprehensive guide to simulations of these signals with the focus on data-driven modeling, from the microscopic level of single neurons and neural networks to macroscopic signals observable with noninvasive electro- and magneto-encephalography. This didactic organization, depth of coverage, and impeccable expertise of the authors make this book a top candidate as a textbook for computational neuroscience courses. Supplementary simulation software, freely available on GitHub, is a fantastic addition for research and teaching.’

‘The brain is an electrochemical organ. The laws of electricity are simple. Yet how currents spread in a heterogeneous, non-isotropic milieu, such as the brain, is super complex. This long needed outstanding book provides all the necessary ingredients to comprehend this complexity. Done with the utmost care, this volume is a must-read for both novices and experts in electrophysiology and I bet it will become the foundation of elective graduate courses for many years to come. The text is the systems neuroscience equivalent of the single-neuron Hodgkin–Huxley model.’ György Buzsáki, NYU Neuroscience Institute, USA; and author of Rhythms of the Brain and The Brain from Inside Out

‘This book is a fantastic resource for the computational neuroscience community and beyond. The introductory ‘guide’ is outstanding in its clarity and description for readers with a range of backgrounds. The presentation is rigorous and detailed with many mathematical equations, and yet readable and understandable, with many figures. The authors are to be commended for their clearly defined terminologies and presentation of complex concepts. A gem of a read for anyone wanting to develop an in-depth understanding of electrical brain recordings and models of them.’ Frances K. Skinner, Krembil Brain Institute, University Health Network and University of Toronto, Toronto, Ontario, Canada