Book contents
- Frontmatter
- Contents
- List of Contributors
- Foreword by Jean-Louis Vincent
- Preface
- Section 1 Hemodynamic Monitoring in the Perioperative Period
- 1 Overview of the Circulation
- 2 Invasive Hemodynamic Monitoring
- 3 Non-Invasive Blood Pressure Monitoring
- 4 Microcirculation and Mitochondrial Dysfunction
- 5 Cerebral Oximetry
- Section 2 Basic Science & Concepts in Fluid Therapy
- Section 3 Practical Use
- Section 4 Future Directions
- Index
4 - Microcirculation and Mitochondrial Dysfunction
from Section 1 - Hemodynamic Monitoring in the Perioperative Period
Published online by Cambridge University Press: 11 April 2024
- Frontmatter
- Contents
- List of Contributors
- Foreword by Jean-Louis Vincent
- Preface
- Section 1 Hemodynamic Monitoring in the Perioperative Period
- 1 Overview of the Circulation
- 2 Invasive Hemodynamic Monitoring
- 3 Non-Invasive Blood Pressure Monitoring
- 4 Microcirculation and Mitochondrial Dysfunction
- 5 Cerebral Oximetry
- Section 2 Basic Science & Concepts in Fluid Therapy
- Section 3 Practical Use
- Section 4 Future Directions
- Index
Summary
Organ dysfunction often occurs in the perioperative setting and in sepsis. Alterations in systemic hemodynamics may play a role, but even when these are within therapeutic goals, organ dysfunction may still occur. Microcirculatory alterations, a key determinant of tissue perfusion and of mitochondrial dysfunction, may play a role in the development of organ dysfunction. In this chapter, we discuss the evidence for alterations in microcirculatory and mitochondrial functions and their relevance, in circulatory failure and in the perioperative setting.
- Type
- Chapter
- Information
- Hemodynamic Monitoring and Fluid Therapy during Surgery , pp. 49 - 56Publisher: Cambridge University PressPrint publication year: 2024