Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-ttngx Total loading time: 0 Render date: 2024-06-02T11:07:24.753Z Has data issue: false hasContentIssue false

30 - Pain in medical illness: ethical and legal foundations

from SECTION X - SYSTEMS OF CARE

Published online by Cambridge University Press:  06 July 2010

PAULINE LESAGE
Affiliation:
Beth Israel Medical Center
RUSSELL K. PORTENOY
Affiliation:
Beth Israel Medical Center and Albert Einstein College of Medicine
Eduardo D. Bruera
Affiliation:
University of Texas, Houston
Russell K. Portenoy
Affiliation:
Albert Einstein College of Medicine, New York
Get access

Summary

No moral impulse seems more deeply embedded than the need to relieve suffering…it has become a foundation stone for the practice of medicine, and it is at the core of the social and welfare programmes of all civilized nations.

Daniel Callahan

Introduction

By introducing major modifications in the historical constructs underlying medical treatments, science and technology have created a certain “chaos” in the care of seriously ill patients. What might have been considered good medical practice for advanced disease before the “biological revolution” is now questioned. Where to draw the line? Where to set limits? Many variables now must be considered in the management of patients with advanced illnesses, including the recognition of ethics as a foundation for clinical practice, the acknowledgment of new rights, and social changes related to health care. Ethical and legal considerations now must constantly inform decision making. Medicine has been caught in a difficult dilemma: Not only does it have to consider its own complexities, but it also has to face a much different social context than existed just a short time ago.

Numerous ethical guidelines and recommendations have been proposed by diverse authorities to help clinicians in their decision making. Recommendations can be found in reports of special presidential or national commissions, in major congressional reports, in policy statements of national organizations, in guidelines from bioethics institutes, and in professional journals.

Type
Chapter
Information
Cancer Pain
Assessment and Management
, pp. 553 - 567
Publisher: Cambridge University Press
Print publication year: 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Callahan, C. The troubled dream of life: in search of a peaceful death. New York: Simon and Schuster, 1993, p 94.Google Scholar
,President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Deciding to forego life-sustaining treatment: ethical, medical, and legal issues in treatment decisions. Washington, DC: U.S. Government Printing Office, 1983.Google Scholar
,Commission dereforme du droit du Canada. Euthanasie, aide au suicide et interruption de traitement. Document de travail 28, Ottawa, Ministere des approvisionnements et services, Canada, 1982.
Life-sustaining technologies and the elderly. Washington, DC: U.S. Congress, Office of Technology Assessment, 1987.
,American Medical Association Council on Ethical and Judicial Affairs. Code of Medical Ethics, 1998, sec.2.20, 46.
,American Nurses Association. Code for nurses with interpretive statements. Silver Spring, MD: American Nurses Publishing, 2001.Google Scholar
,Hastings Center. Guidelines on the termination of life-sustaining treatment and the care of the dying. Bloomington and Indianapolis: Indiana University Press, 1987, p 6.Google Scholar
Wanzer, SH, Adelstein, SJ, Cranford, RE, et al. The physician's responsibility toward hopelessly ill patients. N Engl J Med 310:955–9, 1984.CrossRefGoogle ScholarPubMed
,The SUPPORT Principal Investigators for the SUPPORT Project. A controlled trial to improve care for seriously ill hospitalized patients: the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT). JAMA 274:1591–8, 1995.CrossRefGoogle Scholar
Burns, JP, Mitchell, C, Outwater, KM, et al. End-of-life care in the pediatric intensive care unit after the forgoing of life-sustaining treatment. Crit Care Med 28:3060, 2000.CrossRefGoogle ScholarPubMed
Seckler, AB, Meier, DB, Mulvihill, M, Paris, BEC. Substituted judgment: how accurate are proxy predictions?Ann Intern Med 115:92–8, 1991.CrossRefGoogle ScholarPubMed
Fins, JJ, Solomon, MZ. Communication in intensive care settings: the challenge of futility dispute. Crit Care Med 29(Suppl):N10–15, 2001.CrossRefGoogle Scholar
,American Medical Association Council on Scientific Affairs. Good care of the dying patient. JAMA 275:474–8, 1996.CrossRefGoogle Scholar
,American Board of Internal Medicine End-of-Life Patient Care Project Committee. Caring for the dying: identification and promotion of physician competency. Philadelphia: American Board of Internal Medicine, 1996.Google Scholar
,American College of Physicians Ethics and Human Rights Committee. Ethics manual. Ann Intern Med 117:946–60, 1992.Google Scholar
Jonsen, AR, Siegler, M, Winsdale, WJ. Clinical ethics, 3rd ed. New York: McGraw-Hill, 1992.Google Scholar
Pellegrino, ED. The metamorphosis of medical ethics. JAMA 269:1158–62, 1993.CrossRefGoogle ScholarPubMed
,The President's Council on Bioethics. Taking care. Ethical caregiving in our aging society. Washington, DC, 2005. Available at: www.bioethics.gov.Google Scholar
Beauchamp, TL, Childress, JF, eds. Principles of biomedical ethics, 4th ed. New York: Oxford University Press, 1994.
Portenoy, RK. Contemporary diagnosis and management of pain in oncology and AIDS patients, 3rd ed. Newtown, PA: Handbooks in Health Care Co, 2000, pp 43–5.Google Scholar
Billings, JA. What is palliative care?J Palliat Med 1:73–81, 1998.CrossRefGoogle ScholarPubMed
Cassell, EJ. The nature of suffering and the goals of medicine. N Engl J Med 306:639–45, 1982.CrossRefGoogle Scholar
,Hippocrates. The art. In: Reiser, SJ, Dyck, AJ, Curran, WJ, eds. Ethics in medicine: historical perspectives and contemporary concerns. Cambridge, MA: MIT Press, 1977, pp 6–7.Google Scholar
Rosner, F, Kark, PR, Bennett, AJ, et al. Medical futility. NYS J Med 92:485–8, 1992.Google ScholarPubMed
Schneiderman, LJ, Jecker, NS, Jonsen, AR. Medical futility: its meaning and ethical implications. Ann Intern Med 112:949–54, 1990.CrossRefGoogle ScholarPubMed
Truog, RD, Brett, AS, Frader, J. The problem with futility. N Engl J Med 326:1560–3, 1992.CrossRefGoogle ScholarPubMed
Brett, AS, McCullough, LB. When patients request specific interventions: defining the limits of the physician's obligation. N Engl J Med 315:1347–51, 1986.CrossRefGoogle ScholarPubMed
Cranford, R, Gostin, L. Futility: a concept in search of a definition. J Med Health Care 20:307, 1992.CrossRefGoogle ScholarPubMed
Swanson, JW, McCrary, SV. Doing all they can: physicians who deny medical futility. J Law Med Ethics 22:318–26, 1994.CrossRefGoogle ScholarPubMed
,World Health Organization. Cancer pain relief and palliative care. Geneva: World Health Organization, 1996.Google Scholar
McCrary, SV. Physician's quantitative assessments of medical futility. J Med Ethics 5:100, 1994.Google Scholar
Brody, H. The multiple facets of futility. J Clin Ethics 52:142, 1994.Google Scholar
Younger, SJ. Futility in clinical practice. J Am Geriatr Soc 42:889, 1994.Google Scholar
Katz, J. Informed consent: ethical and legal issues. In: Arras, JD, Steinbock, B, eds. Ethical issues in modern medicine. Mountain View, CA: Mayfield Publishing Co, 1995, pp 87–97.Google Scholar
,Selections from the Hippocratic Corpus “Decorum XVI.” In: Reiser, SJ, Dick, AJ, Curran, WJ, eds. Ethics in medicine. Cambridge, MA: MIT Press, 1977.Google Scholar
Appelbaum, PS, Lidz, CW, Meisel, A. Informed consent. Legal theory and clinical practice. New York: Oxford University Press, 1987.Google Scholar
Neveloff-Dubler, N, Farber-Post, L. Truth telling and informed consent. In: Holland, J, ed. Psycho-oncology. New York: Oxford University Press, 1998.Google Scholar
Emanuel, LL, Barry, MJ, Emanuel, EJ, Stoeckle, JD. Advance directives: can patients' stated treatment choices be used to infer unstated choices?Med Care 32:95–105, 1994.CrossRefGoogle ScholarPubMed
Gillick, MR. Advance care planning. N Engl J Med. 350:7–8, 2004.CrossRefGoogle ScholarPubMed
Eiser, AR, Weiss, MD. The underachieving advance directive: recommendations for increasing advance directive completion. Am J Bioeth 1:W10, 2001.Google ScholarPubMed
Teno, J. et al. Family perspectives on end of life care. JAMA 291:88–93, 2004.CrossRefGoogle ScholarPubMed
Fagerlin, A, Schneider, CE. Enough: the failure of the living will. Hastings Cent Rep 334:30–42, 2004.CrossRefGoogle Scholar
,Oregon Health Sciences University, Center for Ethics of Healthcare. POLST. Available at: http://www.polst.org.
Gregory, J. On the duties and offices of physicians. London: W Straham, 1772.Google Scholar
Pellegrino, ED. Doctors must not kill. J Clin Ethics 3:95–107, 1992.Google Scholar
Somerville, MA. Death of pain: pain, suffering, and ethics. In: Gebhart, GF, Hammond, DL, Jensen, TS, eds. Proceedings of the 7th World Congress on Pain, Progress in Pain Research and Management, vol 2. Seattle: IASP Press, 1994.Google Scholar
State v McAfee, 259 Ga. 579, 385S.L. 2d 651 (Ga.1989).
Estate of Henry James v Hill Haven Corp., Superior Court Div. 89 CVS 64, Hartford County, NC (Jan 15, 1991).
Solomon, MZ, O'Donnell, L, Jennings, B, et al. Decisions near the end of life: professional views of life-sustaining treatments. Am J Public Health 83:14–24, 1993.CrossRefGoogle ScholarPubMed
Twycross, RG, Lack, SA. Therapeutics in terminal cancer. London: Pitman, 1984:184.Google Scholar
Airedale NHS Trust v Bland (1993) 1 all e.r. 821; (1993) 1 h.l.j. 7.
Johnson, S. Disciplinary actions and pain relief: analysis of the Pain Relief Act. J Law Med Ethics 24:319–27, 1996.CrossRefGoogle ScholarPubMed
Vacco v Quill, 117 S Ct 2293 (1997).
Alpers, A. Criminal act or palliative care? Prosecutions involving the care of the dying. J Law Med Ethics 26:308–31, 1998.CrossRefGoogle ScholarPubMed
Wallston, KA, Burger, C, Smith, RA, Baugher, RJ. Comparing the quality of death for hospice and non-hospice cancer patients. Med Care 26:177–82, 1998.CrossRefGoogle Scholar
Ventafridda, V, Ripamonti, C, Conno, F, et al. Symptom prevalence and control during cancer patients' last days of life. J Palliat Care 6:7–11, 1990.Google ScholarPubMed
Byock, I. Dying well: prospects for growth at the end of life. New York: Riverhead Books, 1997.Google Scholar
Coyle, N, Adelhardt, J, Foley, KM, Portenoy, RK. Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life. J Pain Symptom Manage 5:83–93, 1990.CrossRefGoogle ScholarPubMed
Chater, S, Viola, R, Paterson, J, Jarvis, V. Sedation for intractable distress in the dying: a survey of experts. Palliat Med 12:255–69, 1998.CrossRefGoogle Scholar
Cherny, NI, Portenoy, RK. Sedation in the management of refractory symptoms: guidelines for evaluation and treatment. J Palliat Care 10:31–8, 1994.Google ScholarPubMed
Mount, B. Morphine drips, terminal sedation, and slow euthanasia: definitions and facts, not anecdotes. J Palliat Care 12:31–7, 1996.Google Scholar
Quill, T, Lo, B, Brock, D. Palliative options of last resort: a comparison of voluntary stopping eating and drinking, terminal sedation, physician-assisted suicide, and voluntary euthanasia. JAMA 278:2099–104, 1997.CrossRefGoogle Scholar
Graeff, A, Dean, M. Palliative sedation therapy in the last weeks of life: a literature review and recommendations for standards. J Palliat Med 10:67, 2007.CrossRefGoogle ScholarPubMed
,American Medical Association Council on Ethical and Judicial Affairs. Decisions near the end of life. JAMA 267:2229–33, 1992.CrossRefGoogle Scholar
Wanzer, SH, Federman, DD, Adelstein, SJ, et al. The physician's responsibility toward hopelessly ill patients – a second look. N Engl J Med 129:844–9, 1989.CrossRefGoogle Scholar
Byock, IR. When suffering persists. J Palliat Care 10:8–13, 1994.Google ScholarPubMed
Kohara, H, Ueko, H, Takeyama, H. Sedation for terminally ill patients with cancer with uncontrollable physical distress. J Palliat Med 8:20–5, 2005.CrossRefGoogle ScholarPubMed
Morita, T. Differences in physician-reported practice in palliative sedation therapy. Support Care Cancer 12:584–92, 2004.CrossRefGoogle ScholarPubMed
Mueller-Busch, HC, Andres, I, Jehser, T. Sedation in palliative care – a critical analysis of 7 years experience. BMC Palliat Care 2:2, 2003.CrossRefGoogle Scholar
Hook, C, Mueller, PS. The Terri Schiavo saga: the making of a tragedy and lessons learned. Mayo Clinic Proc 80:1449–60, 2005.CrossRefGoogle ScholarPubMed
Cohen, L, Ganzini, L, Mitchell, C, et al: Accusations of murder and euthanasia in end-of-life care. J Palliat Med 8:1096–104, 2005.CrossRefGoogle ScholarPubMed
Gilson, AM, Joranson, . Controlled substances and pain management changes in knowledge and attitudes of state medical regulators. J Pain Symptom Manage 21:227–37, 2001.CrossRefGoogle ScholarPubMed
AAHPM position statement on palliative sedation. J Palliat Med 10:855, 2007.
Billings, J, Block, S. Slow euthanasia. J Palliat Care 12:38–41, 1996.Google ScholarPubMed
Cavanaugh, TA. The ethics of death hastening or death-causing palliative analgesic administration to the terminally ill. J Pain Symptom Manage 12:248–54, 1996.CrossRefGoogle ScholarPubMed
Cherny, N, Coyle, N, Foley, K. Guidelines in the care of the dying cancer patient. Hematol Oncol Clin North Am 1:261–86, 1996.CrossRefGoogle Scholar
,The Hastings Center. Guidelines on the termination of life sustaining treatment in the care of the dying. Briarcliff Manor, NY: The Hastings Center, 1987.Google Scholar
Lesage, P, Latimer, E. Case 2. In: MacDonald, N, Boisvert, M, Dungeon, D, et al., eds. Palliative medicine: a case based manual. New York: Oxford University Press, 1998.Google Scholar
,AGS Ethics Committee. A position statement from the American Geriatrics Society. J Am Geriatr Soc 43:477–8, 1995.Google Scholar
Burt, RA. The Supreme Court speaks. Not assisted suicide but a constitutional right to palliative care. N Engl J Med 337:1234, 1997.CrossRefGoogle Scholar
Meisel, A. Legal myths about terminating life support. Arch Intern Med 151:1497–502, 1991.CrossRefGoogle ScholarPubMed
,AMA, Statement of Council on Ethical and Judicial Affairs. Withholding or withdrawing life-prolonging medical treatment. JAMA 256:471, 1986.CrossRefGoogle Scholar
Blackhall, LJ. Must we always use CPR?N Engl J Med 317:1281–5, 1987.CrossRefGoogle ScholarPubMed
Faber-Langendorf, K. Resuscitation of patients with metastatic cancer: is a transient benefit still futile?Arch Intern Med 151:235–9, 1991.Google Scholar
Cantor, MD, Braddock, CH, Derse, AR, et. al. Do-not-resusitate orders and medical futility. Arch Intern Med 163:2689–94, 2003.CrossRefGoogle Scholar
Lo, B. Unanswered questions about DNR orders. JAMA 265:1874–5, 1991.CrossRefGoogle ScholarPubMed
,Council on Ethical and Judicial Affairs, American Medical Association. Guidelines for the appropriate use of do-not-resuscitate orders. JAMA 265:1868–71, 1991.CrossRefGoogle Scholar
Barber, MD, Fearon, KC, Delmore, G, Loprinzi, CL. Current controversies in cancer: should cancer patients with incurable disease receive parenteral or enteral nutritional support?Eur J Cancer 34:279–85, 1998.CrossRefGoogle ScholarPubMed
Torelli, GF, Campos, AC, Meguid, MM. Use of TPN in terminally ill cancer patients. Nutrition 15:665–7, 1999.CrossRefGoogle ScholarPubMed
Zerwekh, JV. Do dying patients really need IV fluids?Am J Nurs 97:26–31, 1997.Google Scholar
Zerwekh, JV. The dehydration question. Nursing 83:47–51, 1983.CrossRefGoogle Scholar
Viola, RA, Wells, GA, Petersen, J. The effects of fluid status and fluid therapy on the dying: a systemic review. J Palliat Care 13:41–52, 2007.Google Scholar
AAHPM position Statements. J Palliat Med 10:851–7, 2007.CrossRef
Brophy v New England Sinai Hospital 497 N.E. 2d 626 (Mass. 1986).
Cruzan v Director Missouri Dept. of Health, United States Supreme Court, no 88–1503, June 25th, 1990.
Edwards, MJ, Tolle, SW. Disconnecting a ventilator at the request of a patient who knows he will then die: the doctor's anguish. Ann Intern Med 117:254–6, 1992.CrossRefGoogle ScholarPubMed
Wilson, WC, Smedira, NG, Fink, C, et al. Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients. JAMA 267:949–53, 1992.CrossRefGoogle ScholarPubMed
Kelleher, MJ, Chambers, D, Corcoran, P, et al. Euthanasia and related practices world wide. Crisis 19:109–15, 1998.CrossRefGoogle Scholar
Gittelman, DK. Euthanasia and physician-assisted suicide. South Med J 92:369–74, 1999.CrossRefGoogle ScholarPubMed
www.euthanesia.com (accessed 1 May 2009).
Brody, H. Assisted death – a compassionate response to a medical failure. N Engl J Med 327:1384–8, 1992.CrossRefGoogle ScholarPubMed
Meir, , Emmons, CA, Wallenstein, S, et al. A national survey of physician-assisted suicide and euthanasia in the United States. N Engl J Med 338:1193–201, 1998.CrossRefGoogle Scholar
Maas, PJ, Wal, G, Averkate, I, et al. Euthanasia, physician-assisted suicide, and other practices involving the end of life in the Netherlands, 1990–1995. N Engl J Med 335:1699–705, 1996.CrossRefGoogle ScholarPubMed
Maas, PJ, Delden, JJ, Pijnenborg, L. Euthanasia and other medical decisions concerning the end of life: an investigation, vol. 2. New York: Elsevier, 1992.Google Scholar
Miller, IG, Fins, JJ, Snyder, L, et al. Assisted suicide compared with refusal of treatment: a valid distinction?Ann Intern Med 132:470–5, 2000.CrossRefGoogle ScholarPubMed
Emanuel, EJ. Euthanasia: historical, ethical and empiric perspectives. Arch Intern Med 154:1890–901, 1994.CrossRefGoogle ScholarPubMed
Ryan, CJ. Pulling up the runway: the effect of new evidence on euthanasia's slippery slope. J Med Ethics 24:341–4, 1998.CrossRefGoogle Scholar
Brock, DW. Voluntary active euthanasia. Hastings Cent Rep 22:11–22, 1992.CrossRefGoogle ScholarPubMed
Cassel, C, Meir, . Morals and moralism in the debate over euthanasia and assisted suicide. N Engl J Med 323:750–2, 1990.CrossRefGoogle ScholarPubMed
Salem, T. Physician-assisted suicide: promoting autonomy – or medicalizing suicide. Hastings Cent Rep 29:30–6, 1999.CrossRefGoogle ScholarPubMed
Callahan, D. When self-determination runs amok. Hastings Cent Rep 22:52–5, 1992.CrossRefGoogle ScholarPubMed
Ganzini, L, Nelson, HD, Schmidt, TA, et al. Physicians' experience with the Oregon Death With Dignity Act. N Engl J Med 342:557–604, 2000.CrossRefGoogle Scholar
Kass, LR. Is there a right to die?Hastings Cent Rep 23:34–43, 1993.CrossRefGoogle Scholar
Miller, FG, Fins, JJ, Snyder, L. Assisted suicide compared with refusal of treatment: a valid distinction?Ann Intern Med 132:470–5, 2000.CrossRefGoogle ScholarPubMed
Back, AL, Wallace, JI, Starks, HE, Pearlman, RA. Physician-assisted suicide and euthanasia in Washington State. Patient requests and physician responses. JAMA 275:919–25, 1996.CrossRefGoogle ScholarPubMed
Seale, C, Addington-Hall, J. Euthanasia: why people want to die earlier. Soc Sci Med 39:647–54, 1994.CrossRefGoogle ScholarPubMed
Foley, K. The relationship of pain and symptom management to patient request for physician-assisted suicide. J Pain Symptom Manage 6:289–97, 1991.CrossRefGoogle ScholarPubMed
Emanuel, EJ. Ethics of treatment: palliative and terminal care. In: Holland, JC, ed. Psycho-oncology. New York: Oxford University Press, 1998.Google Scholar
Emanuel, EJ, Fairclough, DL, Daniels, ER, Clarridge, BR. Euthanasia and physician-assisted assisted suicide: attitudes and experiences of oncology patients, oncologists, and the public. Lancet 347:1805–10, 1996.CrossRefGoogle Scholar
Breitbart, W, Rosenfeld, BD, Passik, SD. Interest in physician-assisted suicide among ambulatory HIV-infected patients. Am J Psychiatry 153:238–42, 1996.Google ScholarPubMed
,The New York Task Force on Life and the Law. When death is sought: assisted suicide and euthanasia in the medical context. New York: NYS Task Force on Life and the Law, 1994.Google Scholar
Singer, PA, Siegler, M. Euthanasia – a critique. N Engl J Med 322:1881–3, 1990.CrossRefGoogle ScholarPubMed
Capron, AM. Euthanasia in the Netherlands: American observations. Hastings Cent Rep 22:30–3, 1992.CrossRefGoogle ScholarPubMed
Maas, PJ, Delden, JJM, Pinjnenborg, L, Looman, CWM. Euthanasia and other medical decisions concerning the end of life. Lancet 338:669–74, 1991.Google Scholar
Asch, D. The role of critical care nurses in euthanasia and physician-assisted suicide. N Engl J Med 334:1374–9, 1996.CrossRefGoogle Scholar
Caplan, AL, Snyder, L, Faber-Langendoen, K. The role of guidelines in the practice of physician-assisted suicide. Ann Intern Med 132:476–81, 2000.CrossRefGoogle ScholarPubMed
Morrison, RS, Penrod, JD, Cassel, JB, et al. Cost savings associated with US hospitals palliative care consultation programs. Arch Intern Med 168:1783–90, 2008.CrossRefGoogle ScholarPubMed
Glantz, LH. Withholding and withdrawing treatment: the role of the criminal law. Law Med Health Care 15:231–41, 1987–1988.CrossRefGoogle ScholarPubMed
Meisel, A, Grenvick, A, Pinkus, RL, Snyder, JV. Hospital guidelines for deciding about life-sustaining treatment: dealing with health limbo. Crit Care Med 14:239–46, 1986.CrossRefGoogle ScholarPubMed
Miller, DK, Coe, RM, Hyers, TM. Achieving consensus on withdrawing or withholding care for critically ill patients. J Gen Intern Med 7:475–80, 1992.CrossRefGoogle ScholarPubMed
Alpers, A, Lo, B. Futility: not just a medical issue. Law Med Health Care 20:327, 1992.CrossRefGoogle Scholar
Ryan, CJ, Kaye, M. Euthanasia in Australia – the Northern Territory Rights of the Terminally Ill Act. N Engl J Med 334:326–8, 1996.CrossRefGoogle ScholarPubMed
Wecht, CH. The right to die and physician-assisted suicide. Medical, legal, ethical aspects. Part I, II. Med Law 17:477–91, 581–601, 1998.Google Scholar
Stjernsward, J. The international hospice movement from the perspective of the World Health Organization. In: Saunders, C, Kastenbaum, R, eds. Hospice care on the international scene. New York: Springer Publishing Co., 1997, pp 9–15.Google Scholar
,National Hospice and Palliative Care Organization. NHPCO facts and figures: hospice care in America. Available at: http://www.nhpco.org/files/public/Statistics_Research/NHPCO_facts-and-figures_2008.pdf.
Gazelle, G. Understanding hospice – an underutilized option for life's final chapter. N Engl J Med 357:321–4, 2007.CrossRefGoogle ScholarPubMed
Rhymes, JA. Barriers to effective palliative care of terminal patients: an international perspective. Clin Geriatr Med 12:407–16, 1996.Google Scholar
Von Roenn, JH, Cleeland, CS, Gonin, R, et al. Physician attitudes and practice in cancer pain management. A survey from the Eastern Cooperative Oncology Group. Ann Intern Med 119:121–6, 1993.CrossRefGoogle Scholar
Meier, , Morrison, RS, Cassel, CK. Improving palliative care. Ann Intern Med 127:225–30, 1997.CrossRefGoogle ScholarPubMed
Preston, TA. Taking charge of the last stages of life. Final victory. Facing death on your own terms. Roseville, CA: Forum, 2000.Google Scholar
Raeve, L. Ethical issues in palliative care research. Palliat Med 8:298–305, 1994.CrossRefGoogle ScholarPubMed
Mount, BM, Cohen, R, MacDonald, N, et al. Ethical issues in palliative care research revisited. Palliat Med 9:165–70, 1995.CrossRefGoogle ScholarPubMed
Bruera, E, Franco, JJ, Maltoni, M, et al. Changing pattern of agitated impaired mental status in patients with advanced cancer: association with cognitive monitoring, hydration, and opiate rotation. J Pain Symptom Manage 10:287–91, 1995.CrossRefGoogle Scholar
Bruera, E, Spachynski, K, MacEachern, T, Hanson, J. Cognitive failure in cancer patients in clinical trials [letter]. Lancet 341:247–8, 1993.CrossRefGoogle Scholar
Schaeffer, MH, Krantz, DS, Wichman, A, et al. The impact of disease severity on the informed consent process in clinical research. Am J Med 1:261–8, 1996.CrossRefGoogle Scholar
Markman, M. Ethical difficulties with randomized clinical trials involving cancer patients: examples from the field of gynecologic oncology. J Clin Ethics 3:193–5, 1992.Google ScholarPubMed
Guidelines in research in palliative care. London: The National Council for Hospice and Specialist Palliative Care Services, 1995.
Ethical issues in palliative care. In: Doyle, D, Hanks, GW, Cherney, N, Calman, K, eds. Oxford textbook of palliative medicine, 3rd ed. Oxford: Oxford University Press, 2003.
MacDonald, N. Suffering and dying in cancer patients: research frontiers in controlling confusion, cachexia, and dyspnea. West J Med 163:278–86, 1995.Google ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×