Once thought rare, hemochromatosis is now acknowledged as one of the commonest inherited disorders, affecting one in two hundred people of western Caucasian descent. It is estimated to affect over one million people in the USA alone. This is the most comprehensive clinical reference yet on hemochromatosis. The international author team includes specialists in internal medicine, hematology, hepatology, genetics, biochemistry and molecular biology, and the contents cover all aspects of pathophysiology, epidemiology, diagnosis and treatment. The latest developments in the genetics of the disorder are well explained, and there are sections on screening, diagnostic techniques, and clinical complications. Social and ethical issues are also considered. Highly illustrated, up-to-date and authoritative, this is the definitive resource for all clinicians involved in the management of hemochromatosis, and will also be invaluable to scientists interested in iron metabolism and iron overload.

‘This is ‘the bible’ of hemochromatosis … This is the best, most comprehensive review of hemochromatosis and iron metabolism that I have ever encountered. It will become a required reference for anyone treating or researching this disease.’

Lisa Boggio - MD

‘James Barton and Corwin Edwards have assembled a distinguished international array of nearly 100 contributors to cover every aspect of the subject. It is a massive undertaking and is the current definitive text on haemochromatosis. Clearly written and well referenced, there are reviews by researchers - many of whom have been leaders in this topic for over 30 years.’

James S. Dooley Source: The Lancet

‘Throughout this book, the reader can feel the excitement sparked by the discovery of the hemochromatosis (HFE) gene … Specialists will find up-to-date information and invaluable bibliographic resources … The book contains discussions of important issues related to screening for hemochromatosis and a remarkable chapter on social and ethical issues.’

Source: The New England Journal of Medicine

‘Clearly written and well referenced, there are reviews by researchers - many of whom have been leaders in this topic for over 30 years … comprehensive and informative reference text. Hemochromatosis will be valuable not only for scientists and clinicians who are involved in this area, but also for individuals who need a state-of-the-art review of a specific issue.’

James S. Dooley Source: The Lancet

Barton and Edwards have assembled experts from around the world to write highly authoritative articles about all aspects of hemochromatosis. Molecular genetics, genetic epidemiology, pathophysiology, clinical management, and screening are the main topics. Ethical and social issues related to hemochromatosis are also considered. Throughout this book, the reader can feel the excitement sparked by the discovery of the hemochromatosis (HFE) gene. This book is particularly strong in its coverage of clinical genetics … This book, written by 93 diverse authors, is nevertheless a tight collection of compelling and informative chapters, each one contributing to the cogency of the overall discussion.’

Source: The New England Journal of Medicine

‘Hemochromatosis reflects the current wealth of clinical and experimental progress in the area, and reviews the changing understanding of the disorder, its cause, diagnosis, and management.’

James S. Dooley Source: The Lancet

‘This large volume is a remarkable resource of information about haemochromatosis, ranging from the history to social and ethical issues of genetic testing, and including some topics which usually receive little attention, such as the absorption for other metals and infections and immunity.’

Mark Worwood Source: Hum Genet

‘Excellent.’

Source: Journal of Gastroenterology

‘… highlights the importance and advances made relative to hemochromatosis and places this disease in perspective not only as an important entity in inherited disease but in all systematic medicine.’

G. Falkson Source: Oncology