Book contents
- Infertility in the Male
- Infertility in the Male
- Copyright page
- Contents
- Contributors
- Foreword
- Abbreviations
- Introduction
- Section 1 Scientific Foundations of Male Infertility
- Section 2 Clinical Evaluation of the Infertile Male
- Chapter 7 Infertility as a Metric of Men’s Health
- Chapter 8 Office Evaluation of the Subfertile Male
- Chapter 9 Evaluation of the Infertile Male’s Partner
- Chapter 10 Imaging the Male Reproductive System
- Chapter 11 Effects of Environmental Chemicals on Male Reproduction
- Chapter 12 Endocrine Causes of Male Infertility – Diagnosis and Treatment
- Chapter 13 Spermatogenesis – Diagnosis of Normal and Abnormal States
- Chapter 14 Inheritance and Male Fertility
- Chapter 15 The Varicocele – Approaches to Diagnosis and Management
- Chapter 16 Infection, Inflammation, and Immunological Causes of Male Infertility
- Section 3 Laboratory Diagnosis of Male Infertility
- Section 4 Treatment of Male Infertility
- Section 5 Health Care Systems and Culture
- Index
- References
Chapter 7 - Infertility as a Metric of Men’s Health
from Section 2 - Clinical Evaluation of the Infertile Male
Published online by Cambridge University Press: 08 July 2023
Book contents
- Infertility in the Male
- Infertility in the Male
- Copyright page
- Contents
- Contributors
- Foreword
- Abbreviations
- Introduction
- Section 1 Scientific Foundations of Male Infertility
- Section 2 Clinical Evaluation of the Infertile Male
- Chapter 7 Infertility as a Metric of Men’s Health
- Chapter 8 Office Evaluation of the Subfertile Male
- Chapter 9 Evaluation of the Infertile Male’s Partner
- Chapter 10 Imaging the Male Reproductive System
- Chapter 11 Effects of Environmental Chemicals on Male Reproduction
- Chapter 12 Endocrine Causes of Male Infertility – Diagnosis and Treatment
- Chapter 13 Spermatogenesis – Diagnosis of Normal and Abnormal States
- Chapter 14 Inheritance and Male Fertility
- Chapter 15 The Varicocele – Approaches to Diagnosis and Management
- Chapter 16 Infection, Inflammation, and Immunological Causes of Male Infertility
- Section 3 Laboratory Diagnosis of Male Infertility
- Section 4 Treatment of Male Infertility
- Section 5 Health Care Systems and Culture
- Index
- References
Summary
Infertility, defined as the inability to achieve conception following 1 year of unprotected intercourse, is thought to affect 15 percent of couples worldwide [1]. Male factor infertility is suspected to contribute to half of all infertility cases, playing a sole contributory role in 20 percent of cases, while acting concurrently with female factor infertility in 30 percent of cases [2, 3]. Over time, there has been a steadily accumulating body of evidence in the medical literature suggestive of an association between male infertility and other comorbid medical pathologies, demonstrated not only in reported disease prevalence, but also in rates of hospitalization and mortality. Although the exact mechanisms behind these associations remain unclear, and multiple hypotheses have been proposed, implicating genetic, developmental, and lifestyle etiologies (Fig. 7.1). In this chapter, we will review the associations between infertility and comorbidities, as well as the proposed etiologies, in order to illustrate how infertility may be used as an overall metric for men’s health.
- Type
- Chapter
- Information
- Infertility in the Male , pp. 107 - 112Publisher: Cambridge University PressPrint publication year: 2023
References
Further Reading
Choy, JT, Eisenberg, ML. Male infertility as a window to health. Fertil steril 2018;110:810–14.Google Scholar
Hanson, BM, Eisenberg, ML, Hotaling, JM. Male infertility: a biomarker of individual and familial cancer risk. Fertil Steril 2018;109:6–19.Google Scholar
Ventimiglia, E, Montorsi, F, Salonia, A. Comorbidities and male infertility: a worrisome picture. Curr Opin Urol 2016;26:146–51.Google Scholar
References
Zegers-Hochschild, F, Adamson, GD, de Mouzon, J, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 2009;92:1520–4.Google Scholar
Thoma, ME, McLain, AC, Louis, JF, et al. Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertil Steril 2013;99:1324–31.e1.Google Scholar
Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile male: a committee opinion. Fertil Steril 2015;103:e18–25.Google Scholar
Honig, SC, Lipshultz, LI, Jarow, J. Significant medical pathology uncovered by a comprehensive male infertility evaluation. Fertil Steril 1994;62:1028–34.Google Scholar
Kolettis, PN, Sabanegh, ES. Significant medical pathology discovered during a male infertility evaluation. J Urol 2001;166:178–80.Google Scholar
Salonia, A, Matloob, R, Gallina, A, et al. Are infertile men less healthy than fertile men? Results of a prospective case-control survey. Eur Urol 2009;56:1025–31.Google Scholar
Eisenberg, ML, Li, S, Behr, B, Pera, RR, Cullen, MR. Relationship between semen production and medical comorbidity. Fertil Steril 2015;103:66–71.Google Scholar
Shiraishi, K, Matsuyama, H. Effects of medical comorbidity on male infertility and comorbidity treatment on spermatogenesis. Fertil Steril 2018;110:1006–11 e2.Google Scholar
Svartberg, J, von Muhlen, D, Schirmer, H, Barrett-Connor, E, Sundfjord, J, Jorde, R. Association of endogenous testosterone with blood pressure and left ventricular mass in men. The Tromso Study. Eur J Endocrinol 2004;150:65–71.Google Scholar
Fogari, R, Zoppi, A, Preti, P, et al. Sexual activity and plasma testosterone levels in hypertensive males. Am J Hypertens 2002;15:217–21.Google Scholar
Guo, D, Li, S, Behr, B, Eisenberg, ML. Hypertension and male fertility. World J Mens Health 2017;35:59–64.Google Scholar
Eisenberg, ML, Park, Y, Hollenbeck, AR, Lipshultz, LI, Schatzkin, A, Pletcher, MJ. Fatherhood and the risk of cardiovascular mortality in the NIH-AARP Diet and Health Study. Hum Reprod 2011;26:3479–85.Google Scholar
Eisenberg, ML, Li, S, Cullen, MR, Baker, LC. Increased risk of incident chronic medical conditions in infertile men: analysis of United States claims data. Fertil Steril 2016;105:629–36.Google Scholar
Levine, H, Jorgensen, N, Martino-Andrade, A, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod update 2017;23:646–59.Google Scholar
Sermondade, N, Faure, C, Fezeu, L, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 2013;19:221–31.Google Scholar
Schisterman, EF, Mumford, SL, Chen, Z, et al. Lipid concentrations and semen quality: the LIFE study. Andrology 2014;2:408–15.Google Scholar
Bener, A, Al-Ansari, AA, Zirie, M, Al-Hamaq, AO. Is male fertility associated with type 2 diabetes mellitus? Int Urol Nephrol 2009;41:777–84.Google Scholar
Eisenberg, ML, Sundaram, R, Maisog, J, Buck Louis, GM. Diabetes, medical comorbidities and couple fecundity. Hum Reprod 2016;31:2369–76.Google Scholar
Jacobsen, R, Bostofte, E, Engholm, G, et al. Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ 2000;321:789–92.Google Scholar
Walsh, TJ, Croughan, MS, Schembri, M, Chan, JM, Turek, PJ. Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med 2009;169:351–6.Google Scholar
Eisenberg, ML, Li, S, Brooks, JD, Cullen, MR, Baker, LC. Increased risk of cancer in infertile men: analysis of U.S. claims data. J Urol 2015;193:1596–601.Google Scholar
Walsh, TJ, Schembri, M, Turek, PJ, et al. Increased risk of high-grade prostate cancer among infertile men. Cancer 2010;116:2140–7.Google Scholar
Hanson, HA, Anderson, RE, Aston, KI, Carrell, DT, Smith, KR, Hotaling, JM. Subfertility increases risk of testicular cancer: evidence from population-based semen samples. Fertil Steril 2016;105:322–8 e1.Google Scholar
Ruhayel, Y, Giwercman, A, Ulmert, D, et al. Male infertility and prostate cancer risk: a nested case-control study. Cancer Causes Control 2010;21:1635–43.Google Scholar
Anderson, RE, Hanson, HA, Patel, DP, et al. Cancer risk in first- and second-degree relatives of men with poor semen quality. Fertil Steril 2016;106:731–8.Google Scholar
Anderson, RE, Hanson, HA, Lowrance, WT, et al. Childhood cancer risk in the siblings and cousins of men with poor semen quality. J Urol 2017;197:898–905.Google Scholar
Glazer, CH, Tottenborg, SS, Giwercman, A, et al. Male factor infertility and risk of multiple sclerosis: a register-based cohort study. Mult Scler 2018;24:1835–42.Google Scholar
Brubaker, WD, Li, S, Baker, LC, Eisenberg, ML. Increased risk of autoimmune disorders in infertile men: analysis of US claims data. Andrology 2018;6:94–8.Google Scholar
Ortona, E, Pierdominici, M, Maselli, A, Veroni, C, Aloisi, F, Shoenfeld, Y. Sex-based differences in autoimmune diseases. Ann Ist Super Sanita 2016;52:205–12.Google Scholar
Latif, T, Kold Jensen, T, Mehlsen, J, et al. Semen quality as a predictor of subsequent morbidity: a Danish cohort study of 4,712 men with long-term follow-up. Am J Epidemiol 2017;186:910–17.Google Scholar
Jensen, TK, Jacobsen, R, Christensen, K, Nielsen, NC, Bostofte, E. Good semen quality and life expectancy: a cohort study of 43,277 men. Am J Epidemiol 2009;170:559–65.Google Scholar
Eisenberg, ML, Li, S, Behr, B, et al. Semen quality, infertility and mortality in the USA. Hum Reprod 2014;29:1567–74.Google Scholar
Claustres, M. Molecular pathology of the CFTR locus in male infertility. Reprod BioMed Online 2005;10:14–41.Google Scholar
Sun, F, Turek, P, Greene, C, Ko, E, Rademaker, A, Martin, RH. Abnormal progression through meiosis in men with nonobstructive azoospermia. Fertil Steril 2007;87:565–71.Google Scholar
Li, P, Xiao, Z, Braciak, TA, Ou, Q, Chen, G, Oduncu, FS. Systematic immunohistochemical screening for mismatch repair and ERCC1 gene expression from colorectal cancers in China: clinicopathological characteristics and effects on survival. PLoS ONE 2017;12:e0181615.Google Scholar
Zhao, L. Mismatch repair protein expression in patients with stage II and III sporadic colorectal cancer. Oncol Lett 2018;15:8053–61.Google Scholar
Paul, C, Povey, JE, Lawrence, NJ, Selfridge, J, Melton, DW, Saunders, PT. Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE 2007;2:e989.Google Scholar
Reitmair, AH, Schmits, R, Ewel, A, et al. MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet 1995;11:64–70.Google Scholar
Eisenberg, ML, Betts, P, Herder, D, Lamb, DJ, Lipshultz, LI. Increased risk of cancer among azoospermic men. Fertil Steril 2013;100:681–5.Google Scholar
Salzano, A, D’Assante, R, Heaney, LM, et al. Klinefelter syndrome, insulin resistance, metabolic syndrome, and diabetes: review of literature and clinical perspectives. Endocrine 2018;61:194–203.Google Scholar
Swerdlow, AJ, Schoemaker, MJ, Higgins, CD, Wright, AF, Jacobs, PA. Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study. J Natl Cancer Inst 2005;97:1204–10.Google Scholar
Jorgez, CJ, Weedin, JW, Sahin, A, et al. Aberrations in pseudoautosomal regions (PARs) found in infertile men with Y-chromosome microdeletions. J Clin Endocrinol Metab 2011;96:E674–9.Google Scholar
Barker, DJ. The developmental origins of adult disease. J Am Coll Nutr 2004;23:588S–95S.Google Scholar
Calkins, K, Devaskar, SU. Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care 2011;41:158–76.Google Scholar
Skakkebaek, NE, Rajpert-De Meyts, E, Main, KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 2001;16:972–8.Google Scholar
Bang, JK, Lyu, SW, Choi, J, Lee, DR, Yoon, TK, Song, SH. Does infertility treatment increase male reproductive tract disorder? Urology 2013;81:644–8.Google Scholar
Posod, A, Odri Komazec, I, Kager, K, et al. Former very preterm infants show an unfavorable cardiovascular risk profile at a preschool age. PLoS ONE 2016;11:e0168162.Google Scholar
Bloomfield, FH. Impact of prematurity for pancreatic islet and beta cell development. J Endocrinol 2018;238:R161–71.Google Scholar
Belva, F, Bonduelle, M, Roelants, M, et al. Semen quality of young adult ICSI offspring: the first results. Hum Reprod 2016;31:2811–20.Google Scholar
Li, Y, Lin, H, Li, Y, Cao, J. Association between socio-psycho-behavioral factors and male semen quality: systematic review and meta-analyses. Fertil Steril 2011;95:116–23.Google Scholar
Jensen, TK, Hjollund, NH, Henriksen, TB, et al. Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy. BMJ 1998;317:505–10.Google Scholar
Jensen, TK, Swan, S, Jorgensen, N, et al. Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA. Hum Reprod 2014;29:1801–9.Google Scholar