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Chapter 11 - Imaging Genetic and Epigenetic Markers in Mood Disorders

from Section 4 - Novel Approaches in Brain Imaging

Published online by Cambridge University Press:  12 January 2021

By
Sara Poletti ,
Elena Mazza ,
Benedetta Vai  and
Francesco Benedetti
Edited by
Sudhakar Selvaraj ,
Paolo Brambilla  and
Jair C. Soares
Sudhakar Selvaraj
Affiliation:
UTHealth School of Medicine, USA
Paolo Brambilla
Affiliation:
Università degli Studi di Milano
Jair C. Soares
Affiliation:
UT Harris County Psychiatric Center, USA
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Summary

Genetics explain 60–85% and 31–50% of the risk to develop, respectively, bipolar disorder (BD) (1, 2) and major depressive disorder (MDD) (3, 4). Thus, hereditability has emerged as a crucial factor in the pathophysiology of mood disorders. Early genetics studies focused their attention on specific single-nucleotide polymorphism (SNP), preselected on prior evidence for their functional role in coding products that may influence relevant features of the disorders, also known as candidate gene approach. In these studies, we define risk allele, genetic variants associated with the disorder or worse clinical features such as reduced response to therapeutics, early onset, and higher recurrence.

Type
Chapter
Information
Mood Disorders
Brain Imaging and Therapeutic Implications
 , pp. 135 - 150
Publisher: Cambridge University Press
Print publication year: 2021

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