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Chapter 26 - Peripheral Nerve Injury Response Mechanisms

from Section 2 - Clinical Neurosurgical Diseases

Published online by Cambridge University Press:  04 January 2024

By
Andrew S. Jack  and
Line Jacques
Edited by
Farhana Akter ,
Nigel Emptage ,
Florian Engert  and
Mitchel S. Berger
Farhana Akter
Affiliation:
Harvard University, Massachusetts
Nigel Emptage
Affiliation:
University of Oxford
Florian Engert
Affiliation:
Harvard University, Massachusetts
Mitchel S. Berger
Affiliation:
University of California, San Francisco
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Summary

The peripheral nervous system(PNS) comprises spinal and cranial nerves, which include motor, sensory, and autonomic nerves, as well as their roots, trunks, plexuses, ganglia, and accompanying supportive connective tissue distal to the brain and spinal cord. It is located peripheral to the central nervous system(CNS), and has very little in the way of protection from injury. In contrast to the CNS, it has a much higher innate capacity for repair and recovery after injury. Despite its physiological diversity, the PNS has a highly organized and choreographed injury response mechanism partially explaining its improved outcomes post-injury. In this chapter, we discuss the pathophysiology of peripheral nerve injury(PNI) and its ensuing reparative response. Before delving into PNIs and their classifications, it is important to review the basic anatomic organization of the PNS, its key cellular components, and supporting connective tissue.

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Chapter
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Neuroscience for Neurosurgeons , pp. 348 - 354
Publisher: Cambridge University Press
Print publication year: 2024

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