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Chapter 51 - Sickle Cell Anemia in Pregnancy

from Section 9 - Hematologic Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Amira El-Messidi  and
Alan D. Cameron
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 29-year-old primigravida with sickle cell anemia (SCA) is referred by her primary care provider to your tertiary center’s high-risk obstetrics unit for prenatal care of a sonographically confirmed single viable intrauterine pregnancy at 8+2 weeks’ gestation. She has no obstetric complaints.

Keywords

Sickle-cell anemia, inherited hemoglobinopathy, pregnancyComorbiditiesInvestigationsGenetic risk, prenatal testingPerinatal risks, complications, maternal-fetal morbidity, adverse outcomeAntepartum, intrapartum, postpartum managementAcute painful vaso-occlusive episodePhysiology, pathophysiologyPhysical examinationRisk factors, acute pain episodeBlood transfusionObstetric deliveryContraceptionThromboprophylaxis
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 645 - 661
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

ACOG Committee on Obstetrics. ACOG Practice Bulletin No. 78: hemoglobinopathies in pregnancy. Obstet Gynecol. 2007;109(1):229–237.CrossRefGoogle Scholar
Boga, C, Ozdogu, H. Pregnancy and sickle cell disease: A review of the current literature. Crit Rev Oncol Hematol. 2016;98:364–374.CrossRefGoogle ScholarPubMed
Eissa, AA, tuck, SM. Sickle cell disease and β-thalassemia major in pregnancy. The Obstetrician and Gynaecologist 2013;15:71–78.CrossRefGoogle Scholar
Ezihe-Ejiofor, A, Jackson, J. Peripartum considerations in sickle cell disease. Curr Opin Anaesthesiol. 2021;34(3):212–217.CrossRefGoogle ScholarPubMed
Green-Top Guideline. Management of Sickle Cell Disease in Pregnancy. London: Royal College of Obstetricians and Gynaecologists; 2011.Google Scholar
Howard, J, Oteng-Ntim, E. The obstetric management of sickle cell disease. Best Pract Res Clin Obstet Gynaecol. 2012;26(1):25–36.CrossRefGoogle ScholarPubMed
Okusanya, BO, Oladapo, OT. Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy. Cochrane Database Syst Rev. 2016;12(12):CD010378.Google ScholarPubMed
Oteng-Ntim, E, Meeks, D, Seed, PT, et al. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis. Blood. 2015;125(21):3316–3325.CrossRefGoogle ScholarPubMed
Patil, V, Ratnayake, G, Fastovets, G. Clinical ‘pearls’ of maternal critical care Part 2: sickle-cell disease in pregnancy. Curr Opin Anaesthesiol. 2017;30(3):326–334.CrossRefGoogle ScholarPubMed
Smith-Whitley, K. Complications in pregnant women with sickle cell disease. Hematology Am Soc Hematol Educ Program. 2019;2019(1):359–366.CrossRefGoogle ScholarPubMed

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