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Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism

Published online by Cambridge University Press:  24 June 2014

Omar Šerý ,
Renáta Hladilová ,
Miroslav Novotný ,
Hana Hríbková ,
Vladimír Znojil  and
Petr Zvolský
Omar Šerý*
Affiliation:
Laboratory of Neurobiology and Molecular Psychiatry, Department of Comparative Animal Physiology and General Zoology, Masaryk University, Faculty of Science, Brno
Renáta Hladilová
Affiliation:
Laboratory of Neurobiology and Molecular Psychiatry, Department of Comparative Animal Physiology and General Zoology, Masaryk University, Faculty of Science, Brno
Miroslav Novotný
Affiliation:
Department of Psychiatry, Charles University, 1st Medical Faculty, Praha
Hana Hríbková
Affiliation:
Laboratory of Neurobiology and Molecular Psychiatry, Department of Comparative Animal Physiology and General Zoology, Masaryk University, Faculty of Science, Brno
Vladimír Znojil
Affiliation:
Department of Pathological Physiology, Masaryk University, Faculty of Medicine, Brno, Czech Republic
Petr Zvolský
Affiliation:
Department of Psychiatry, Charles University, 1st Medical Faculty, Praha
*
Laboratory of Neurobiology and Molecular Psychiatry, Department of Comparative Animal Physiology and General Zoology, Faculty of Science, Masaryk University, Kotlárská 2, 611 37 Brno, Czech Republic. Tel: + 420 541129 625; Fax: + 420 541238 815; E-mail: omarsery@sci.muni.cz
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Abstract

Objectives:

IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. The aim of the present association study was to examine the effect of the G/C -174 polymorphism of the IL-6 gene on disposition to alcoholism.

Methods:

We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects.

Results:

The significant difference in G allele frequency between alcoholic group (0.52) and control group (0.59) was found (P < 0.03).

Conclusion:

To our knowledge, this is the first finding providing evidence for an association between alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between the IL-6 gene and alcoholism is discussed.

Keywords

alcohol dependenceassociationcytokineIL-6polymorphism
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 5 , October 2003 , pp. 257 - 261
Copyright
Copyright © 2003 Blackwell Munksgaard

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