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The serotonin-2A receptor polymorphism and clinical symptoms in mood disorders, schizophrenia and alcohol dependence in Japan

Published online by Cambridge University Press:  24 June 2014

Hayato Terayama ,
Takahiro Takimoto ,
Isao Fukunishi ,
Masahiro Itoh  and
Kazuhiko Iwahashi
Hayato Terayama
Affiliation:
Department of Neurophysiology, Graduate School of Azabu University, Sagamihara-shi, Kanagawa First Department of Anatomy, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan
Takahiro Takimoto
Affiliation:
Department of Neurophysiology, Graduate School of Azabu University, Sagamihara-shi, Kanagawa
Isao Fukunishi
Affiliation:
Department of Liaison Psychiatry and Psychosomatics, Tokyo Institute of Psychiatry, Setagaya-ku, Tokyo
Masahiro Itoh
Affiliation:
First Department of Anatomy, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan
Kazuhiko Iwahashi*
Affiliation:
Department of Neurophysiology, Graduate School of Azabu University, Sagamihara-shi, Kanagawa Health Administration Center, Azabu University, Sagamihara-shi, Kanagawa
*
Health Administration Center, University of Azabu, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229–8501, Japan. Tel./Fax: 81-42-769-1930; E-mail: iwahashi@azabu-u.ac.jp
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Abstract

In the past, there have been many epidemiological and genetic studies of mood disorders, schizophrenia, and alcohol dependence, and in this study, the human serotonin 2A receptor (5-HTR2A) polymorphism was examined in 80 patients with mood disorders, 50 patients with schizophrenia and 41 patients with alcohol dependence. 5-HTR is related to affectivity, regulation, and pharmacologic effects of antidepressant, anti-anxiety and antipsychotic medications. The polymorphism in 5-HTR2A (102T/C, −1438 A/G) was identified by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP). The results suggest that 5-HTR2A (102T/C, −1438G/A) polymorphism might not be associated with susceptibility to schizophrenia or mood disorders, and it might not be a risk factor contributing to alcohol dependency. We found that the 102T/C polymorphism was in linkage disequilibrium with the −1438G/A polymorphism in psychosis (mood disorder, schizophrenia, and alcohol dependence) and in health controls. Further studies are needed to determine whether or not the novel serotonin receptor (5-HTR) polymorphism reflects the pathogenesis of schizophrenia, mood disorders, and alcohol dependence.

Keywords

SchizophreniaMood disordersAlcohol dependence5-HTR2ALinkage
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 3 , June 2003 , pp. 129 - 132
Copyright
Copyright © 2003 Blackwell Munksgaard

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