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The relationship between protein nutrition, reproductive effort and breakdown in immunity to Teladorsagia circumcincta in periparturient ewes

Published online by Cambridge University Press:  18 August 2016

J.G. M. Houdijk ,
I. Kyriazakis ,
F. Jackson  and
R. L. Coop
J.G. M. Houdijk
Affiliation:
Animal Nutrition and Health Department, Animal Biology Division, Scottish Agricultural College, Kings Buildings, Edinburgh EH9 3JG, UK
I. Kyriazakis
Affiliation:
Animal Nutrition and Health Department, Animal Biology Division, Scottish Agricultural College, Kings Buildings, Edinburgh EH9 3JG, UK
F. Jackson
Affiliation:
Moredun Research Institute, Pentland Science Park, Bush Loan, Penicuik EH26 0PZ, UK
R. L. Coop
Affiliation:
Moredun Research Institute, Pentland Science Park, Bush Loan, Penicuik EH26 0PZ, UK
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Abstract

A nutritional hypothesis for the occurrence of the periparturient relaxation of immunity (PPRI) to gastrointestinal nematodes was tested within the bounds of a nutrient partitioning framework. It was hypothesized that at times of a scarce supply of metabolizable protein (MP), an increase in MP supply or a reduction in MP demand (having singles instead of twins) should lower the extent of PPRI in sheep. Twenty-one single- and 21 twin-bearing and -rearing Finn-Dorset ewes, 2 to 7 years old, and repeatedly infected with Teladorsagia circumcincta, were given one of three pelleted foods (no. = 7). The foods were formulated to supply 0·8 (L), 1·0 (M) and 1·2 (H) times the MP requirements during lactation, and were offered ad libitum from d–21 to d35 (d0 is day of parturition). Faecal egg counts (FEC) were assessed twice weekly as an indicator for host resistance. Dry-matter intake (DMI) during late pregnancy was higher than expected, and MP supply did not limit performance at this stage. In accordance with the hypothesis, there were no indications of a breakdown of immunity to T. circumcincta during late pregnancy. DMI during lactation did not differ between the single- and twin-rearing ewes. Calculated milk production was lower for the L than for the M and H ewes, especially for the twin-rearing ewes. A temporarily elevated FEC was observed during the first few days in lactation, which was probably mainly due to changes in faecal output rather than to PPRI. The FEC returned to low, late pregnancy levels at d12 and remained low for the single- but not for the twin-rearing ewes (P < 0·001). Overall, the L ewes had higher FEC than the M and H ewes from d19 onwards; this effect was more pronounced for the twin- than for the single-rearing ewes. It was postulated that DMI achieved overcame MP scarcity and thus prevented breakdown in immunity in the single-rearing ewes. The data support the view that, at times of MP scarcity, an increase in MP supply and reduction in MP demand can lower the extent of the breakdown in immunity towards T. circumcincta.

Keywords

lactationimmunitynematodanutritionpregnancysheep
Type
Ruminant, nutrition, behaviour and production
Information
Animal Science , Volume 72 , Issue 3 , June 2001 , pp. 595 - 606
Copyright
Copyright © British Society of Animal Science 2001

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References

Agricultural and Food Research Council. 1993. Energy and protein requirements of ruminants. An advisory manual prepared by the AFRC Technical Committee on Responses to Nutrients. CAB International, Wallingford.Google Scholar
Agricultural Research Council. 1990. The nutrient requirements of ruminant livestock. Technical review by an Agricultural Research Council working party. CAB International, Wallingford.Google Scholar
Anderson, J. M. L., Barclay, M. N. I., Harvey, M. J. and Waterhouse, A. 1998. A comparative study of fat and protein levels in the colostrum of prolific and non-prolific sheep. Proceedings of the British Society of Animal Science, 1998, p. 104.Google Scholar
Barger, I. A. 1993. Influence of sex and reproductive status on susceptibility of ruminants to nematode parasitism. International Journal for Parasitology 23: 463–469.Google Scholar
Barnes, E. H. and Dobson, R. J. 1993. Persistence of acquired immunity to Trichostrongylus colubriformis in sheep after termination of infection. International Journal for Parasitology 23: 1019–1026.Google Scholar
Christie, M. and Jackson, F. 1982. Specific identification of strongyle eggs in small samples of sheep faeces. Research in Veterinary Science 32: 113–117.Google Scholar
Coop, R. L., Huntley, J. F. and Smith, W. D. 1995. Effect of dietary protein supplementation on the development of immunity to Ostertagia circumcincta in growing lambs. Research in Veterinary Science 59: 24–29.Google Scholar
Coop, R. L. and Kyriazakis, I. 1999. Nutrition-parasite interaction. Veterinary Parasitology 84: 187–204.Google Scholar
Coop, R. L., Sykes, A. R. and Angus, K. W. 1982. The effect of three levels of intake of Ostertagia circumcincta larvae on growth rate, food intake and body composition of growing lambs. Journal of Agricultural Science, Cambridge 98: 247–255.Google Scholar
Cooper, S. D. B., Kyriazakis, I. and Oldham, J. D. 1994. The effect of late pregnancy on the diet selections made by ewes. Livestock Production Science 40: 263–275.Google Scholar
Donaldson, J., Houtert, M. F. J. van and Sykes, A. R. 1998. The effect of nutrition on the periparturient parasite status of mature sheep. Animal Science 67: 523–533.Google Scholar
Emmans, G. C. and Kyriazakis, I. 2000. Issues arising from genetic selection for growth and body composition characteristics in poultry and pigs. In The challange of genetic change in animal production (ed. Hill, W. G., Bishop, S. C., McGuirk, B., McKay, J. C., Simm, G. and Webb, A. J.), British Society of Animal Science occasional publication no. 27, pp 36–53.Google Scholar
Gibbs, H. C. and Barger, I. A. 1986. Haemonchus contortus and other trichostrongylid infections in parturient, lactating and dry ewes. Veterinary Parasitology 22: 57–66.Google Scholar
Houdijk, J. G. M., Kyriazakis, I., Jackson, F. and Coop, R. L. 2000a. Effects of protein and energy supply on the resistance to nematodes in pregnant ewes. Proceedings of the British Society of Animal Science, 2000 p. 33.CrossRefGoogle Scholar
Houdijk, J. G. M., Kyriazakis, I., Jackson, F., Huntley, J. F. and Coop, R. L. 2000b. Can an increased metabolizable protein intake affect the periparturient relaxation in immunity against Teladorsagia circumcincta in sheep? Veterinary Parasitology 91: 43–62.CrossRefGoogle ScholarPubMed
Huntley, J. F., Gibson, S., Brown, D., Smith, W. D., Jackson, F. and Miller, H. R. P. 1987. Systemic release of a mast cell proteinase following nematode infections in sheep. Parasite Immunology 9: 603–614.Google Scholar
Huntley, J. F., Schallig, H. D. F. H., Kooyman, F. N. J., MacKellar, A., Jackson, F. and Smith, W. D. 1998. IgE antibody during infection with the ovine abomasal nematode, Teladorsagia circumcincta: primary and secondary responses in serum and gastric lymph of sheep. Parasite Immunology 20: 565–571.CrossRefGoogle ScholarPubMed
Jackson, F., Jackson, E. and Williams, J. T. 1988. Susceptibility of the pre-parturient ewe to infection with Trichostrongylus vitrinus and Ostertagia circumcincta . Research in Veterinary Science 45: 213–218.Google Scholar
Jeffcoate, I. A., Wedrychowicz, H., Fishwick, G., Dunlop, E. M., Duncan, J. L. and Holmes, P. H. 1992. Pathophysiology of the periparturient egg rise in sheep: a possible role for IgA. Research in Veterinary Science 53: 212–218.CrossRefGoogle ScholarPubMed
Jessop, N. S. 1997. Protein metabolism during lactation. Proceedings of the Nutrition Society 56: 169–175.Google Scholar
Johnson, N. L., Kotz, S. and Balakrishnan, N. 1998. Continuous univariate distributions, vol. 1, second edition. PWS-KENT, Boston.Google Scholar
Kyriazakis, I., Emmans, G. C. and Whittemore, C. T. 1991. The ability of pigs to control their protein intake when fed in three different ways. Physiology and Behavior 50: 1197–1203.Google Scholar
Lawes Agricultural Trust. 1993. Genstat 5 release 3·2, reference manual, second edition. Clarendon Press, Oxford.Google Scholar
MacRae, J. C. 1993. Metabolic consequences of intestinal parasitism. Proceedings of the Nutrition Society 52: 121–130.CrossRefGoogle ScholarPubMed
O’Sullivan, B. M. and Donald, A. D. 1973. Responses to infection with Haemonchus contortus and Trichostrongylus colubriformis in ewes of different reproductive status. International Journal for Parasitology 3: 521–530.Google Scholar
Robinson, J. J., Foster, W. H. and Forbes, T. J. 1969. The estimation of the milk yield of a ewe from body weight data on the suckling lamb. Journal of Agricultural Science, Cambridge 72: 103–107.Google Scholar
Robinson, J. J., Sinclair, K. D. and McEvoy, T. G. 1999. Nutritional effects on foetal growth. Animal Science 68: 315–331.Google Scholar
Stear, M. J., Bishop, S. C., Doligalska, M., Duncan, J. L., Holmes, P. H., Irvine, J., McCririe, L., McKellar, Q. A., Sinski, E. and Murray, M. 1995. Regulation of egg production, worm burden, worm length and worm fecundity by host responses in sheep infected with Ostertagia circumcincta . Parasite Immunology 17: 643–652.Google Scholar
Taylor, St C. S. 1980. Live-weight growth from embryo to adult in domesticated mammals. Animal Production 31: 223–235.Google Scholar
Tolkamp, B. J., Dewhurst, R. J., Friggens, N. C., Kyriazakis, I., Veerkamp, R. F. and Oldham, J. D. 1998. Diet choice by dairy cows. 1. Selection of feed protein content during the first half of lactation. Journal of Dairy Science 81: 2657–2669.Google Scholar
Yakoob, A., Holmes, P. H. and Armour, J. 1983. Pathophysiology of gastrointestinal trichostrongyles in sheep: plasma losses and changes in plasma pepsinogen levels associated with parasite challenge of immune animals. Research in Veterinary Science 34: 305–309.Google Scholar