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Dietary cyclic fatty acids derived from linolenic acid do not exhibit intrinsic toxicity in the rat during gestation

Published online by Cambridge University Press:  01 October 2008

L. Bretillon ,
A. Roy ,
B. Pasquis  and
J.-L. Sébédio
L. Bretillon*
Affiliation:
UMR1129 FLAVIC, INRA, F-21000 Dijon, France
A. Roy
Affiliation:
UMR1019 Nutrition Humaine, Plate forme Exploration du Métabolisme, INRA, F-63000 Clermont-Ferrand, France
B. Pasquis
Affiliation:
UMR1129 FLAVIC, INRA, F-21000 Dijon, France
J.-L. Sébédio
Affiliation:
UMR1019 Nutrition Humaine, Plate forme Exploration du Métabolisme, INRA, F-63000 Clermont-Ferrand, France
*
E-mail: bretillon@dijon.inra.fr
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Abstract

Heating oils and fats may lead to cyclization of polyunsaturated fatty acids, especially those showing multiple double bonds like linolenic acid. Cyclohexenyl and cyclopentenyl fatty acids are subsequently present in some edible oils and these were suspected to induce metabolic disorders. When fed during gestation in the rat, cyclic fatty acids were historically reported to induce high mortality of the neonates. Nevertheless, none of these studies have been performed with cyclic fatty acids fed as triacylglycerols, limiting the nutritional value of the conclusions. Therefore, we assessed the toxicity of a diet containing 0.7% of cyclic fatty acids fed as triacylglycerols during gestation and the first days of life in the rat. In this work, we report no deleterious effect of cyclic fatty acids in the mothers and neonates. However, cyclic fatty acids induced a tremendous insulinopenia in the mothers and pups that was associated with the reduction of food intake in the gestating females. Such a finding may be a plausible explanation for the adverse effects of cyclic fatty acids observed previously with higher doses of cyclic fatty acids. Based on present data, on previous ones showing elimination of cyclic fatty acids, and considering their low amounts in the diet, we suggest that cyclic fatty acids formed from cyclization of linolenic acid are not a major concern for human safety.

Keywords

dietcyclic fatty acid monomerslinolenic acidtoxicityinsulinopenia
Type
Full Paper
Information
animal , Volume 2 , Issue 10 , October 2008 , pp. 1534 - 1537
Copyright
Copyright © The Animal Consortium 2008

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